[1]刘树馨,时立新,张淼,等.HbA1c对中老年人糖尿病及糖调节受损诊断价值的探讨[J].国际内分泌代谢杂志,2016,36(06):361-365.[doi:10.3760/cma.j.issn.1673-4157.2016.06.01]
　Liu Shuxin,Shi Lixin,Zhang Miao,et al.Debate on the value of HbA1c in the diagnosis of diabetes and impaired glucose regulation in middle aged and elderly people[J].International Journal of Endocrinology and Metabolism,2016,36(06):361-365.[doi:10.3760/cma.j.issn.1673-4157.2016.06.01]
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HbA1c对中老年人糖尿病及糖调节受损诊断价值的探讨()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年06期
页码:
361-365
栏目:
论著
出版日期:
2016-11-20

文章信息/Info

Title:
Debate on the value of HbA1c in the diagnosis of diabetes and impaired glucose regulation in middle aged and elderly people
作者:
刘树馨; 时立新; 张淼; 张巧; 彭年春; 徐淑静; 张松; 胡颖
550004 贵阳,贵州医科大学附属医院内分泌代谢病科(第一作者现在贵州医科大学附属医院综合病房)
Author(s):
Liu Shuxin;  Shi Lixin; Zhang Miao;  Zhang Qiao;  Peng Nianchun;  Xu Shujing; Zhang Song;  Hu Ying.
Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
关键词:
HbA1c;  糖尿病;  糖调节受损
Keywords:
HbA1c;  Diabetes mellitus;  Impaired glucose regulation
DOI:
10.3760/cma.j.issn.1673-4157.2016.06.01
摘要:
目的 探讨HbA1c诊断中老年人糖尿病、糖调节受损的最佳切点。方法 采用整群随机抽样方法选取贵阳市云岩区40岁及以上,且居住5年以上的中老年人共8 803名。所有研究对象进行口服葡萄糖耐量试验(OGTT)及检测HbA1c等指标。对HbA1c诊断糖尿病、糖调节受损的切点进行分析; 按年龄分层分析HbA1c诊断糖尿病在不同年龄段的切点。结果 HbA1c诊断新发现糖尿病的切点为6.4%的特异性较高(86.8%),相应的敏感性为68.0%。HbA1c诊断糖调节受损的受试者工作曲线下面积偏低(0.558)。40～49 岁年龄组HbA1c诊断糖尿病的切点值最低,为6.1%; 而70～岁年龄组HbA1c诊断糖尿病切点值最高,为6.6%。结论 中老年人群中HbA1c 6.4%为诊断糖尿病的最佳切点,HbA1c不适合作为诊断糖调节受损的指标。
Abstract:
Objective To investigate the best cut-off points of HbA1c for the diagnosis of diabetes and impaired glucose regulation(IGR)in middle aged and elderly people. Methods A total of 8 803 subjects, aged over 40 years old and lived in the community for more than 5 years, were selected from Yunyan District of Guiyang city using a cluster random sampling method. All subjects received oral glucose tolerance test(OGTT)and HbA1c checking. The cut-off points of HbA1c for diagnosis of diabetes and IGR were analyzed and compared between populations with different age. Results The cut-off point of HbA1c was 6.4% for diagnosis of new diabetes with the specificity of 86.8% and the sensitivity of 68.0%. The maximum area of the receiver operating curve of HbA1c was low in the diagnosis of IGR(0.558).Among populations with different age, the lowest cut-off point of HbA1c(6.1%)was found in subjects aged 40-49 years old whereas the highest cut-off point of HbA1c(6.6%)was found in subjects aged over 70 years. Conclusions The best cut-off point of HbA1c for the diagnosis of diabetes is 6.4% for middle-aged and elderly people. HbA1c may not be a good marker for the diagnosis of IGR.

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备注/Memo

备注/Memo:
基金项目:贵州省科技厅社会攻关计划(SY[2010]3150)
更新日期/Last Update: 2016-12-20