[1]刘晓妮 王颖 李桃桃 马小敏 梁彦.血管紧张素转换酶基因rs4353多态性 与糖尿病微血管病变的相关性研究[J].国际内分泌代谢杂志,2018,38(03):149-153.[doi:10.3760/cma.j.issn.1673-4157.2018.03.002]
　Liu Xiaoni*,Wang Ying,Li Taotao,et al.Association between angiotensin converting enzyme gene rs4353 polymorphism and diabetic microangiopathy[J].International Journal of Endocrinology and Metabolism,2018,38(03):149-153.[doi:10.3760/cma.j.issn.1673-4157.2018.03.002]
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血管紧张素转换酶基因rs4353多态性 与糖尿病微血管病变的相关性研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年03期
页码:
149-153
栏目:
论著
出版日期:
2018-05-20

文章信息/Info

Title:
Association between angiotensin converting enzyme gene rs4353 polymorphism and diabetic microangiopathy
作者:
刘晓妮 王颖 李桃桃 马小敏 梁彦
716000 延安市人民医院内分泌科(刘晓妮、王颖、李桃桃、马小敏); 727000 铜川市人民医院肾脏内分泌科(梁彦)
Author(s):
Liu Xiaoni*;  Wang Ying;  Li Taotao;  Ma Xiaomin;  Liang Yan.*
Department of Endocrinology, Yan'an People's Hospital, Anan 716000, China
关键词:
血管紧张素转换酶;  基因多态性;  2型糖尿病;  糖尿病微血管病变;  糖尿病视网膜病变;  糖尿病肾病
Keywords:
Angiotensin converting enzyme;  Gene polymorphism;  Type 2 diabetes mellitus;  Diabetic microangiopathy;  Diabetic retinopathy;  Diabetic nephropathy
DOI:
10.3760/cma.j.issn.1673-4157.2018.03.002
摘要:
目的 探讨血管紧张素转换酶(ACE)基因rs4353、rs4461142和rs8066114位点多态性与糖尿病微血管病变的相关性。方法 选择2016年1月至2017年1月在延安市人民医院治疗的675例2型糖尿病(T2DM)患者,按照是否合并微血管病变分为糖尿病视网膜病变(DR)+/糖尿病肾病(DN)+组130例、DR+/DN-组118例、DR-/DN+组236例和DR-/DN-组191例。采用PCR-限制性片段长度多态性法检测ACE基因rs4353、rs4461142和rs8066114多态性,并收集患者一般病史资料及主要生化指标进行统计学分析。结果 与DR-/DN-组相比,DR+/DN+组、DR+/DN-组、DR-/DN+组GG基因型和G等位基因分布频率差异均具有统计学意义(χ2=7.075～8.951,P均<0.01); 各组rs4461142和rs8066114位点基因型和等位基因分布频率差异均无统计学意义(P均>0.05)。多因素logistic回归分析结果显示,ACE基因rs4353位点G等位基因是糖尿病微血管病变的保护性因素(OR=0.715, 95%CI:0.418～0.923,P=0.007)。结论 对于T2DM患者ACE基因rs4353位点多态性可能与糖尿病微血管病变易感性相关。
Abstract:
Objective To investigate the association between angiotensin-converting enzyme(ACE)gene rs4353, rs4461142, rs8066114 polymorphism and diabetic microangiopathy. Methods A total of 675 patients with type 2 diabetes mellitus(T2DM)hospitalized in Yan'an People's Hospital from January 2016 to January 2017 were recruited to participate in the study. According to their status of diabetic microangiopathy, they were divided into diabetic retinopathy(DR)+/diabetic nephropathy(DN)+ group(n=130), DR+/DN- group(n=118), DR-/DN+ group(n=236)and DR-/DN- group(n=191). Genotype was determined by PCR-restriction fragment length polymorphism for the ACE gene rs4353, rs4461142 and rs8066114 polymorphism. Other general clinical data and biochemical indices were collected for statistical analysis.Results Compared with DR-/DN- group, the GG genotype and G allele frequencies of ACE gene rs4353 in DR+/DN+ group, DR+/DN- group and DR-/DN+ group were significantly different(χ2=7.075-8.951, all P<0.01). However, the genotype and allele frequencies of rs4461142 and rs8066114 did not differ among four groups(all P>0.05). Multivariate logistic regression analysis showed that G allele of rs4353 was protective factor for diabetic microangiopathy(OR=0.715, 95%CI:0.418-0.923, P=0.007).Conclusion ACE gene rs4353 polymorphism may be closely related to the susceptibility of diabetic microangiopathy for patients with T2DM.

参考文献/References:


[1] Purushothaman KR,Krishnan P,Purushothaman M,et al.Expression of angiotensin-converting enzyme 2 and its end product angiotensin 1-7 is increased in diabetic atheroma:implications for inflammation and neovascularization[J].Cardiovasc Pathol,2013,22(1):42-48.DOI:10.1016/j.carpath.2012.05.004.
[2] Fadini GP,Mancuso P,Bertolini F,et al.Amelioration of glucose control mobilizes circulating pericyte progenitor cells in type 2 diabetic patients with microangiopathy[J].Exp Diabetes Res,2012,2012:274363.DOI:10.1155/2012/274363.
[3] 李相友,丁国华,夏瑗瑜,等.血管紧张素1-7对糖尿病大鼠肾小管间质纤维化的影响[J]. 中华肾脏病杂志, 2012, 28(10):798-803. DOI:10.3760/cma.j.issn.1001-7097.2012.10.010.
[4] Lu Y,Ge Y,Hu Q,et al.Association between angiotensin-converting enzyme gene polymorphism and diabetic retinopathy in the Chinese population[J].J Renin Angiotensin Aldosterone Syst,2012,13(2):289-295.DOI:10.1177/1470320311432187.
[5] Luo S,Shi C,Wang F,et al.Association between the angiotensin-converting enzyme(ACE)genetic polymorphism and diabetic retinopathy--a meta-analysis comprising 10,168 subjects[J].Int J Environ Res Public Health,2016,13(11).pii: E1142.DOI:10.3390/ijerph13111142.
[6] 赵鑫丽,赵晓霞,张萱.2型糖尿病易感基因与糖尿病慢性并发症的关系[J]. 中国实验诊断学,2014,(6):1034-1036.
[7] Fenwick EK,Xie J,Man REK,et al.Combined poor diabetes control indicators are associated with higher risks of diabetic retinopathy and macular edema than poor glycemic control alone[J].PLoS One,2017,12(6):e0180252.DOI:10.1371/journal.pone.0180252.
[8] Murea M,Ma L,Freedman BI.Genetic and environmental factors associated with type 2 diabetes and diabetic vascular complications[J].Rev Diabet Stud,2012,9(1):6-22.DOI:10.1900/RDS.2012.9.6.
[9] Zhou MS,Schulman IH,Zeng Q.Link between the renin-angiotensin system and insulin resistance: implications for cardiovascular disease[J].Vasc Med,2012,17(5):330-341.DOI:10.1177/1358863X12450094.
[10] 钟兴,许娴,王长江,等.中国汉族人血管紧张素转换酶基因多态性与糖尿病视网膜病变相关性Meta分析[J]. 安徽医科大学学报,2005,40(3):258-261. DOI:10.3969/j.issn.1000-1492.2005.03.019.
[11] 左彦方,龙爱梅,黄晓青,等.血管紧张素转换酶基因多态性与2型糖尿病肾病相关性的Meta分析[J]. 中国循证医学杂志,2012,12(9):1071-1075.DOI:10.3969/j.issn.1672-2531.2012.09.007.
[12] Martínez-Rodríguez N,Posadas-Romero C,Villarreal-Molina T,et al.Single nucleotide polymorphisms of the angiotensin-converting enzyme(ACE)gene are associated with essential hypertension and increased ACE enzyme levels in Mexican individuals[J].PLoS One,2013,8(5):e65700.DOI:10.1371/journal.pone.0065700.
[13] 张阳东,田亚平,董振南,等.汉族健康人群血管紧张素转换酶多态性及其血清水平的研究[J]. 中国实验诊断学, 2010, 14(7):1061-1063.DOI:10.3969/j.issn.1007-4287.2010.07.031.
[14] Chung CM,Wang RY,Chen JW,et al. A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor[J].Pharmacogenomics J,2010,10(6):537-544.DOI:10.1038/tpj.2009.70.

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通信作者:梁彦,Email:hletian51@163.com
更新日期/Last Update: 2018-03-30