[1]梁绮君 余寿益 胡晨鸣 李淑华 陈诗慧 杨焱 莫巧璇.乙醛脱氢酶2基因多态性与空腹血糖受损的 相关性[J].国际内分泌代谢杂志,2019,39(04):222-225.[doi:10.3760/cma.j.issn.1673-4157.2019.04.002]
　Liang Qijun,Yu Shouyi,Hu Chenming,et al.Association of aldehyde dehydrogenase 2 genetic polymorphism and impaired fasting glucose[J].International Journal of Endocrinology and Metabolism,2019,39(04):222-225.[doi:10.3760/cma.j.issn.1673-4157.2019.04.002]
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乙醛脱氢酶2基因多态性与空腹血糖受损的 相关性()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年04期
页码:
222-225
栏目:
论著
出版日期:
2019-07-20

文章信息/Info

Title:
Association of aldehyde dehydrogenase 2 genetic polymorphism and impaired fasting glucose
作者:
梁绮君 余寿益 胡晨鸣 李淑华 陈诗慧 杨焱 莫巧璇
佛山市中医院健康管理中心 528000
Author(s):
Liang Qijun;  Yu Shouyi;  Hu Chenming;  Li Shuhua;  Chen Shihui;  Yang Yan;  Mo Qiaoxuan
Department of Health Management Center, Foshan Hospital of Traditional Chinese Medicine, Foshan 528000, China
关键词:
乙醛脱氢酶2;  基因多态性;  空腹血糖受损;  β细胞功能
Keywords:
Aldehyde dehydrogenase 2;  Genetic polymorphism;  Impaired fasting glucose;  β cell function
DOI:
10.3760/cma.j.issn.1673-4157.2019.04.002
摘要:
目的 研究中国汉族人群乙醛脱氢酶2(ALDH2)基因多态性与空腹血糖受损的关系。方法 纳入2 213名中国汉族不饮酒的健康体检人群,其中男性1 576人,女性637人。检测ALDH2基因型,测量身高、体重、血压、空腹血糖、血脂、尿酸和空腹血清胰岛素水平。运用稳态模型2(HOMA2)计算器计算胰岛β细胞功能指数(HOMA2%-β)和胰岛素抵抗指数(HOMA2-IR),评估胰岛素抵抗水平和胰岛β细胞功能。应用logistic回归分析空腹血糖受损的危险因素。结果(1)突变型基因组(ALDH2*1/2、ALDH2*2/2)的体重指数显著低于野生型基因组(ALDH2*1/1)(男性t=4.92,女性t=2.44,P均<0.05)。(2)突变型基因组的空腹血糖水平和空腹血糖受损的患病率显著高于野生型基因组(男性t=6.76, χ2=51.78; 女性t=7.12, χ2=12.50,P均<0.05)。Logistic回归分析显示,年龄、体重、ALDH2*2突变是空腹血糖受损的独立危险因素(男性OR=1.89,95%CI:1.52～2.36; 女性OR=1.89,95%CI:1.29～2.78,P均<0.05)。(3)突变型基因组的HOMA2%-β水平显著低于野生型基因组(男性t=12.03,女性t=10.69,P均<0.05)。引入HOMA2%-β后,回归分析显示ALDH2基因型与空腹血糖受损无显著相关(P均>0.05)。结论 ALDH2*2突变增加中国汉族人群空腹血糖受损的发病风险,可能与损伤胰岛β细胞功能有关。
Abstract:
Objective To investigate the association of aldehyde dehydrogenase 2(ALDH2)genetic polymorphism and impaired fasting glucose.Methods A total of 2 213 Chinese Han non-drinkers, including 1 576 men and 637 women, were enrolled at the time of health checkup. ALDH2 genotype, height, weight, blood pressure, fasting plasma glucose, lipid profile, uric acid and fasting serum levels of insulin were measured. Homeostasis model assessment 2 of β cell function(HOMA2%-β)and insulin resistance(HOMA2-IR)assessed by HOMA calculator were used to estimate the β cell function and insulin resistance. Logistic regression analysis was used to analyze the risk of impaired fasting glucose.Results(1)Weight was significantly lower in ALDH2 mutant genotypes(ALDH2*1/2 and ALDH2*2/2)group than that in wide genotype group(ALDH2*1/1)(male t=4.92, female t=2.44, all P<0.05).(2)The level of fasting plasma glucose and the prevalence of impaired fasting glucose were significantly higher in ALDH2 mutant genotypes group than those in wide genotype group(male t=6.76, χ2=51.78; female t=7.12, χ2=12.50, all P<0.05). Logistic regression analysis showed that age, weight and ALDH2 mutant genotypes were independent risks factor for impaired fasting glucose(men OR=1.89, 95%CI:1.52-2.36, women OR=1.89, 95%CI:1.29-2.78, all P<0.05).(3)The level of HOMA2%-β was lower in ALDH2 mutant genotypes group than that in wide genotype group(male t=12.03, female t=10.69, all P<0.05). When HOMA2%-β was included for adjustment, logistic regression analysis showed that there was no relationship between ALDH2 genotypes and impaired fasting glucose(all P>0.05).Conclusion ALDH2 polymorphism is associated with an increased risk of impaired fasting glucose in Chinese Han population, and could be partly explained by impairment of β cell function.

参考文献/References:

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备注/Memo

备注/Memo:
通信作者:梁绮君,Email: sam03815@hotmail.com
Corresponding author: Liang Qijun, Email:sam03815@hotmail.com
基金项目:佛山市卫生和计划生育局医学科研项目(20180067)
Fund program:Medical Research Projects of Foshan Health and Family Planning Bureau(20180067)
更新日期/Last Update: 2019-11-29