[1]潘娟 陈霞.2型糖尿病患者FNDC5基因多态性 与颈动脉粥样硬化相关性研究[J].国际内分泌代谢杂志,2019,39(03):155-159.[doi:10.3760/cma.j.issn.1673-4157.2019.03.003]
　Pan Juan,Chen Xia.Association between FNDC5 gene polymorphism and carotid atherosclerosis in patients with type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2019,39(03):155-159.[doi:10.3760/cma.j.issn.1673-4157.2019.03.003]
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2型糖尿病患者FNDC5基因多态性 与颈动脉粥样硬化相关性研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年03期
页码:
155-159
栏目:
论著
出版日期:
2019-05-20

文章信息/Info

Title:
Association between FNDC5 gene polymorphism and carotid atherosclerosis in patients with type 2 diabetes mellitus
作者:
潘娟1 陈霞2
1延安市人民医院老年病科 716000; 2延安市人民医院内分泌科 716000
Author(s):
Pan Juan1;  Chen Xia2
1Department of Geriatrics, Yan'an People's Hospital, Yan'an 716000, China; 2Department of Endocrinology, Yan'an People's Hospital, Yan'an 716000, China
关键词:
含Ⅲ型纤连蛋白域蛋白5;  Irisin;  颈动脉粥样硬化;  2型糖尿病;  基因多态性
Keywords:
Fibronectin type Ⅲ domain-containing protein 5;  Irisin;  Carotid atherosclerosis;  Type 2 diabetes mellitus;  Gene polymorphism
DOI:
10.3760/cma.j.issn.1673-4157.2019.03.003
摘要:
目的 探讨2型糖尿病(T2DM)患者含Ⅲ型纤连蛋白域蛋白5(FNDC5)基因多态性与颈动脉粥样硬化(CAS)的关系。方法 选择2017年1月至2018年7月在延安市人民医院老年病科治疗的358例T2DM患者(T2DM组),根据颈动脉超声检查结果分为无CAS组和CAS组,另选择同期200名健康体检者作为对照组。采用基质辅助激光解析电离飞行时间质谱法检测所有研究对象FNDC5基因rs16835198、rs3480和rs1570569位点基因型。结果 与对照组相比,T2DM组rs16835198、rs3480及rs1570569基因型和等位基因分布频率差异均无统计学意义(χ2=0.279～2.582,P均>0.05)。与无CAS组相比,CAS组在rs16835198位点GG基因型和G等位基因分布频率均显著升高(χ2=14.129,P=0.001; χ2=14.177,P=0.000),在rs1570569位点T等位基因分布频率显著升高(χ2=4.423,P=0.035)。Logistic多因素回归分析结果显示,FNDC5基因rs16835198位点G等位基因是T2DM患者发生CAS的危险因素(OR=1.786,95%CI:1.136～2.809,P=0.001)。结论 T2DM患者FNDC5基因rs16835198位点多态性可能与CAS易感性相关。
Abstract:
Objective To investigate the relationship between fibronectin type Ⅲ domain-containing protein 5(FNDC5)gene polymorphism and carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 358 patients with T2DM who were hospitalized in the Department of Geriatrics in Yan'an People's Hospital from January 2017 to July 2018 were recruited in this study(T2DM group). These patients were divided into non-CAS group and CAS group according to the results of carotid ultrasonography. Meanwhile, 200 healthy volunteers were selected as control group. Genotype was determined by matrix assisted laser desorption/ionization time-of-flight mass spectrometry for the rs16835198, rs3480 and rs1570569 polymorphism of FNDC5 gene in all subjects.Results Compared with control group, there was no significant difference in genotype and allele frequencies of rs16835198, rs3480 and rs1570569 in T2DM group(χ2=0.279-2.582, all P>0.05). The GG genotype and G allele frequencies of rs16835198 in CAS group were significantly higher than those in non-CAS group(χ2=14.129, P=0.001; χ2=14.177, P=0.000). The T allele frequency of rs1570569 in CAS group was also significantly higher than that in non-CAS group(χ2=4.423, P=0.035). The results of logistic regression analysis showed that G allele of rs16835198 was risk factor for CAS in patients with T2DM(OR=1.786, 95%CI: 1.136-2.809, P=0.001).Conclusion The rs16835198 polymorphism of FNDC5 gene may be related to the susceptibility of CAS for patients with T2DM.

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备注/Memo

备注/Memo:
通信作者:陈霞,Email:981809026@163.com
基金项目:陕西省卫计委科技计划(2016D065)
Corresponding author: Chen Xia, Email:981809026@163.com
Fund program:Science & Technology Plan of Shanxi Provincial Health and Family Planning Commission(2016D065)
更新日期/Last Update: 2019-05-20