[1]吕亚亚 魏素虹 安思芹 何启娟 李永红 刘菊香 刘静 权金星.Endocan与糖尿病周围神经病变的 相关性研究[J].国际内分泌代谢杂志,2019,39(03):151-154,159.[doi:10.3760/cma.j.issn.1673-4157.2019.03.002]
　Lyu Yaya,Wei Suhong,An Siqin,et al.The correlation between endocan and diabetic peripheral neuropathy[J].International Journal of Endocrinology and Metabolism,2019,39(03):151-154,159.[doi:10.3760/cma.j.issn.1673-4157.2019.03.002]
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Endocan与糖尿病周围神经病变的 相关性研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年03期
页码:
151-154,159
栏目:
论著
出版日期:
2019-05-20

文章信息/Info

Title:
The correlation between endocan and diabetic peripheral neuropathy
作者:
吕亚亚1 魏素虹1 安思芹1 何启娟2 李永红3 刘菊香1 刘静1 权金星1
1甘肃省人民医院内分泌科,甘肃省内分泌代谢病重点实验室,兰州 730000; 2甘肃省人民医院体检中心,兰州 730000; 3甘肃省人民医院临床检验中心,兰州 730000
Author(s):
Lyu Yaya1;  Wei Suhong1;  An Siqin1;  He Qijuan2;  Li Yonghong3;  Liu Juxiang1;  Liu Jing1;  Quan Jinxing1
1Department of Endocrinology, Key Laboratory of Metabolic Diseases, Gansu Provincial Hospital, Lanzhou 730000, China; 2Department of Physical Examination Center, Gansu Provincial Hospital, Lanzhou 730000, China; 3Department of Clinical Laboratory, Gansu Provincial Hospital, Lanzhou 730000, China
关键词:
Endocan;  糖尿病周围神经病变;  2型糖尿病
Keywords:
Endocan;  Diabetic peripheral neuropathy;  Type 2 diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2019.03.002
摘要:
目的 探讨血清endocan水平与糖尿病周围神经病变(DPN)的相关性。方法 选取2015年4月至2015年11月在甘肃省人民医院内分泌科住院的2型糖尿病(T2DM)患者67例,分为DPN组(25例)和单纯T2DM组(42例),同期性别、年龄匹配的28名健康志愿者作为正常对照组(NC组)。采用ELISA法测定血清endocan水平,同时测定其他代谢指标。应用Pearson相关分析、logistic回归及受试者工作特征(ROC)曲线分析endocan与DPN的相关性。结果 与NC组相比,DPN组及单纯T2DM组血清endocan水平明显升高(F=24.26,P<0.05),且与单纯T2DM组相比,DPN组血清endocan水平显著升高(t=5.668,P<0.05)。Endocan与病程、年龄呈正相关(r=0.438、0.394,P均<0.05)。Endocan、吸烟、年龄是DPN的危险因素(OR=1.692、9.880、1.093,95% CI:1.279～2.237、2.039～47.878、1.024～1.168,P均<0.05)。ROC分析结果显示,endocan曲线下面积为0.824(95% CI:0.727～0.921,P=0.000)。结论 Endocan与DPN相关,可能是DPN的一种新的生物学标志物。
Abstract:
Objective To investigate the correlation between serum endocan level and risk of diabetic peripheral neuropathy(DPN).Methods A total of 67 patients with type 2 diabetes mellitus(T2DM)were recruited from the Department of Endocrinology in Gansu Provincial Hospital From April 2015 to November 2015. All patients were divided into DPN group(n=25)and simple T2DM group(n=42). Meanwhile, gender and age matched healthy subjects were included as the normal control group(NC group, n=28). Serum endocan was measured by ELISA, and other metabolic parameters were also tested. Pearson correlation analysis, logistic regression analysis and area of receiver operator characteristic(ROC)curve analysis were used to analyze the correlation between endocan level and DPN risk.Results Compared with NC group, the serum level of endocan was significantly increased in simple T2DM group and DPN group(F=24.26, P<0.05). In addition, compared with simple T2DM group, the serum level of endocan in DPN group was markedly higher(t=5.668, P<0.05). Endocan was positively correlated with the course of disease and age(r=0.438, 0.394, all P<0.05). Endocan level, smoking and age were the independent risk factors for DPN(OR=1.692, 9.880, 1.093, 95% CI:1.279-2.237, 2.039-47.878, 1.024-1.168, all P<0.05). The results of the ROC analysis revealed that the area under ROC curve was 0.824(95% CI:0.727-0.921, P=0.000).Conclusion Serum level of endocan is related to DPN, and it may be used as a novel biomarker for DPN.

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备注/Memo

备注/Memo:
通信作者:权金星,Email:quanxt@sina.com
基金项目:国家自然科学基金(81260136,81860091)
Corresponding author: Quan Jinxing, Email: quanxt@sina.com
Fund program:National Natural Science Foundation of China(81260136, 81860091)
更新日期/Last Update: 2019-05-20