[1]赵耕 张盈莹 谢云.血清糖化白蛋白、同型半胱氨酸与糖尿病 合并心血管疾病的相关性研究[J].国际内分泌代谢杂志,2018,38(03):145-148.[doi:10.3760/cma.j.issn.1673-4157.2018.03.001]
　Zhao Geng,Zhang Yingying,Xie Yun.Relationship between serum glycated albumin, homocysteine and diabetic cardiovascular disease[J].International Journal of Endocrinology and Metabolism,2018,38(03):145-148.[doi:10.3760/cma.j.issn.1673-4157.2018.03.001]
点击复制

血清糖化白蛋白、同型半胱氨酸与糖尿病 合并心血管疾病的相关性研究()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年03期
页码:
145-148
栏目:
论著
出版日期:
2018-05-20

文章信息/Info

Title:
Relationship between serum glycated albumin, homocysteine and diabetic cardiovascular disease
作者:
赵耕 张盈莹 谢云
300070 天津医科大学代谢病医院检验科
Author(s):
Zhao Geng;  Zhang Yingying;  Xie Yun
Department of Clinical Laboratory, The Metabolic Disease Hospital, Tianjin Medical University, Tianjin 300070, China
关键词:
糖化白蛋白;  同型半胱氨酸;  糖尿病心血管疾病;  2型糖尿病
Keywords:
Glycated albumin;  Homocysteine;  Diabetic cardiovascular disease;  Type 2 diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2018.03.001
摘要:
目的 探讨糖化白蛋白(GA)、同型半胱氨酸(Hcy)水平与糖尿病合并心血管疾病的关系。方法 选取天津医科大学代谢病医院2015年5月至2016年5月住院的2型糖尿病患者358例作为研究对象。根据是否合并心血管疾病及症状分为糖尿病合并心血管疾病组(202例)和糖尿病无心血管疾病组(156例),同时以健康查体者152名作为正常对照组。比较各组间一般生化指标及GA、Hcy的含量,并进行受试者工作特征(ROC)曲线分析,确定相应的临床诊断界值。结果 糖尿病合并心血管疾病组GA(F=12.863,P<0.05)、Hcy(F=9.792,P<0.05)水平显著高于糖尿病无心血管疾病组和正常对照组; 且糖尿病合并心血管疾病组的GA与Hcy水平呈正相关(r=0.946,P<0.05)。血清GA诊断糖尿病合并心血管疾病的ROC曲线下面积为 0.865 2,敏感性为 90.38%,特异性为 56.28%(95% CI: 0.824 2～0.906 2),Youde指数最大点对应的诊断界值为 17.36%; Hcy诊断糖尿病合并心血管疾病组的ROC曲线下面积为 0.910 3,敏感性为 92.75%,特异性为75.89%(95% CI: 0.878 1～0.942 6),Youde指数最大点对应的诊断界值为13.25 μmol/L。结论 血清GA、Hcy与糖尿病心血管疾病相关,二者联合检测可以作为糖尿病心血管疾病的早期预警指标。
Abstract:
Objective To investigate the relationship between serum glycated albumin(GA), homocyste(Hcy)and diabetic cardiovascular disease.Methods A total of 358 patients with type 2 diabetes mellitus in the Metabolic Disease Hospital of Tianjin Medical University from May 2015 to May 2016 were enrolled in this study. According to their status of cardiovascular disease and symptoms, the patients were divided into diabetes with cardiovascular disease group(n=202)and diabetes without cardiovascular disease group(n=156). Another 152 healthy person were choosed as normal control group. The levels of general biochemical indexes, GA and Hcy were compared, and the receiver operating characteristic(ROC)curve analysis was used to determine the clinical diagnostic threshold for cardiovascular disease in diabetes.Results The levels of GA(F=12.863, P<0.05)and Hcy(F=9.792, P<0.05)in diabetes with cardiovascular group were significantly higher than those in diabetes without cardiovascular disease group and normal control group. And the level of GA was positively correlated with Hcy level in diabetes with cardiovascular group(r=0.946, P<0.05). The area under the ROC curve in the diagnosis of diabetic cardiovascular disease for serum GA was 0.865 2; the sensitivity was 90.38% and the specificity was 56.28%(95% CI: 0.824 2-0.906 2). The diagnostic threshold of GA was 17.36% with a maximum value of Youde index. The area under the ROC curve in the diagnosis of diabetes with cardiovascular disease for serum Hcy was 0.910 3; the sensitivity was 92.75% and the specificity was 75.89%(95% CI: 0.878 1-0.942 6). The diagnostic threshold of Hcy was 13.25 μmol/L with a maximum value of Youde index.Conclusions Serum GA and Hcy are correlated with diabetic cardiovascular disease. The combination of GA and Hcy can be used as early predictors in diabetic cardiovascular disease.

参考文献/References:


[1] Guariguata L,Whiting DR,Hambleton I,et al.Global estimates of diabetes prevalence for 2013 and projections for 2035[J].Diabetes Res Clin Pract,2014,103(2):137-49.DOI:10.1016/j.diabres.2013.11.002.
[2] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中国糖尿病杂志,2014,22(8):后插2-后插42.DOI:10.3969/j.issn.1006-6187.2014.08.027.
[3] 梁伟,赵列宾,王魏,等. 2型糖尿病合并冠心病患者血清同型半胱氨酸水平的研究[J].中华内分泌代谢杂志,2002,18(4):311-312.DOI:10.3760/j.issn:1000-6699.2002.04.023.
[4] Wang Y,Zhao X,Liu L,et al.Prevalence and outcomes of symptomatic intracranial large artery stenoses and occlusions in China: the Chinese Intracranial Atherosclerosis(CICAS)Study[J].Stroke,2014,45(3):663-669.DOI:10.1161/STROKEAHA.113.003508.
[5] 王姗姗,孟玲玲,李玉珠,等.糖基化终末产物对 2 型糖尿病患者睡眠障碍与心血管疾病关系的影响[J].天津医药,2016,44(8):943-947.DOI:10.11958/20150325.
[6] Okura T,Miyoshi K,Irita J,et al.Hyperhomocysteinemia is one of the risk factors associated with cerebrovascular stiffness in hypertensive patients, especially elderly males[J].Sci Rep,2014,4:5663.DOI:10.1038/srep05663.
[7] Pan J,Zou J,Bao Y,et al. Use of glycated albumin to distinguish occult diabetes mellitus from stress-induced hyperglycemia in Chinese orthopedic trauma patients[J].J Trauma Acute Care Surg,2012,72(5):1369-1374.DOI:10.1097/TA.0b013e3182464ba4.
[8] Di Tomo P,Di Silvestre S,Cordone VG,et al.Centella asiatica and lipoic acid, or a combination thereof, inhibit monocyte adhesion to endothelial cells from umbilical cords of gestational diabetic women[J].Nutr Metab Cardiovasc Dis,2015,25(7):659-666.DOI:10.1016/j.numecd.2015.04.002.
[9] Smith DE,Smulders YM,Blom HJ,et al.Determinants of the essential one-carbon metabolism metabolites, homocysteine, S-adenosylmethionine, S-adenosylhomocysteine and folate, in cerebrospinal fluid[J].Clin Chem Lab Med,2012,50(9):1641-1647.DOI:10.1515/cclm-2012-0056.
[10] Takahashi S,Uchino H,Shimizu T,et al. Comparison of glycated albumin(GA)and glycated hemoglobin(HbA1c)in type 2 diabetic patients: usefulness of GA for evaluation of short-term changes in glycemic control[J].Endocr J,2007,54(1):139-144.
[11] Thethi TK,Bajwa MA,Ghanim H,et al.Effect of paricalcitol on endothelial function and inflammation in type 2 diabetes and chronic kidney disease[J].J Diabetes Complications,2015,29(3):433-437.DOI:10.1016/j.jdiacomp.2015.01.004.
[12] Sukhova GK,Wang B,Libby P,et al.Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice[J].Circ Res,2005,96(3):368-375. DOI:10.1161/01.RES.0000155964.34150.F7.
[13] Hanssen NM,Beulens JW,van Dieren S,et al.Plasma advanced glycation end products are associated with incident cardiovascular events in individuals with type 2 diabetes: a case-cohort study with a median follow-up of 10 years(EPIC-NL)[J].Diabetes,2015,64(1):257-265.DOI:10.2337/db13-1864.
[14] Smith KJ,Béland M,Clyde M,et al.Association of diabetes with anxiety: a systematic review and meta-analysis[J].J Psychosom Res,2013,74(2):89-99.DOI:10.1016/j.jpsychores.2012.11.013.
[15] Hegab Z,Gibbons S,Neyses L,et al.Role of advanced glycation end products in cardiovascular disease[J].World J Cardiol,2012,4(4):90-102.DOI:10.4330/wjc.v4.i4.90.
[16] 赵新秀,王仁萍,胡松,等.冠状动脉粥样硬化性心脏病患者血清同型半胱氨酸与糖化白蛋白及氧化高密度脂蛋白水平的其相关性研究[J].中国全科医学,2014,17(12):1338-1341.DOI:10.3969/j.issn.1007-9572.2014.12.003.

相似文献/References:

[1]樊立娜 李鹏辉 王芳 王祯 张雪晴 耿杨.糖尿病足患者血清同型半胱氨酸 及胱抑素C水平变化的研究[J].国际内分泌代谢杂志,2015,(06):374.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.004]
　Fan Lina,Li Penghui,Wang Fang,et al.Serum level of homocysteine and cystatin C in patients with diabetic foot[J].International Journal of Endocrinology and Metabolism,2015,(03):374.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.004]
[2]王海敏,汤旭磊.白藜芦醇对去卵巢骨质疏松大鼠血同型 半胱氨酸和氧化应激指标的影响[J].国际内分泌代谢杂志,2016,36(01):20.[doi:10.3760/cma.j.issn.1673-4157.2016.01.005]
　Wang Haimin,Tang Xulei..Effects of resveratrol on plasma homocysteine and oxidative stress in ovariectomized osteoporotic rats[J].International Journal of Endocrinology and Metabolism,2016,36(03):20.[doi:10.3760/cma.j.issn.1673-4157.2016.01.005]
[3]吴丹,李竹.H型高血压患者血尿酸与左心室重构的关系[J].国际内分泌代谢杂志,2023,43(02):91.[doi:10.3760/cma.j.cn121383-20211129-11083]
　Wu Dan,Li Zhu..Relationship between serum uric acid and left ventricular remodeling in patients with H-type hypertension[J].International Journal of Endocrinology and Metabolism,2023,43(03):91.[doi:10.3760/cma.j.cn121383-20211129-11083]

备注/Memo

备注/Memo:

通信作者:谢云,Email: xieyuntj@126.com
更新日期/Last Update: 2018-03-30