[1]狄红杰,刘超.饮食干预对非酒精性脂肪性肝病肠道菌群的影响[J].国际内分泌代谢杂志,2017,37(04):254-257.
 Di Hongjie,Liu Chao..Effects of diet interventions on gut microbiota of nonalcoholic fatty liver disease[J].International Journal of Endocrinology and Metabolism,2017,37(04):254-257.
点击复制

饮食干预对非酒精性脂肪性肝病肠道菌群的影响()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年04期
页码:
254-257
栏目:
综述
出版日期:
2017-07-20

文章信息/Info

Title:
Effects of diet interventions on gut microbiota of nonalcoholic fatty liver disease
作者:
狄红杰刘超
210028 南京中医药大学附属中西医结合医院内分泌代谢病院区
Author(s):
Di Hongjie Liu Chao.
Endocrine and Diabetes Center,Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing 210028, China
关键词:
肠道菌群 非酒精性脂肪性肝病 饮食干预
Keywords:
Gut microbiota Nonalcoholic fatty liver disease Diet intervention
文献标志码:
A
摘要:
非酒精性脂肪性肝病(NAFLD)的发生与遗传和环境密切相关,肠道菌群在其发生和发展中发挥了重要作用,调节肠道菌群已成为干预NAFLD的重要靶点之一。无论是饮食总量还是结构都会对肠道菌群产生直接且长期的影响。通过低脂饮食、增加饮食中不饱和脂肪酸或者增加难以吸收的多糖等方式调整饮食结构,可以有效调节肠道菌群并治疗NAFLD,但高蛋白饮食的作用还存在争议。
Abstract:
The occurrence of nonalcoholic fatty liver disease(NAFLD)is correlated with genetic susceptibility and environmental factors. The gut microbiota plays a key role in the pathogenesis and development of NAFLD. The modification of gut microbiota has been proposed as a therapeutic approach for the treatment of NAFLD. The diet and the composition are able to have direct and long-term impact on the gut microbiota composition and function. Any modulation of the diet, such as low-fat diet, increasing unsatuated fatty acids and incorporating a larger proportion of non-digestible carbohydrates into the diet may be effective modulating the gut microbiota and have therapeutic effects on NAFLD. But there are some controversies about the effects of diet high in protein.

参考文献/References:

[1] Younossi ZM, Otgonsuren M, Henry L,et al. Association of nonalcoholic fatty liver disease(NAFLD)with hepatocellular carcinoma(HCC)in the United States from 2004 to 2009[J].Hepatology,2015,62(6):1723-1730. DOI:10.1002/hep.28123.
[2] Henao-Mejia J, Elinav E, Jin C,et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity[J].Nature,2012,482(7384):179-185. DOI:10.1038/nature10809.
[3] Singh SP, Misra B, Kar SK,et al. Nonalcoholic fatty liver disease(NAFLD)without insulin resistance: is it different?[J].Clin Res Hepatol Gastroenterol,2015,39(4):482-488. DOI:10.1016/j.clinre.2014.08.014.
[4] Buzzetti E, Pinzani M, Tsochatzis EA. The multiple-hit pathogenesis of non-alcoholic fatty liver disease(NAFLD)[J]. Metabolism, 2016,65(8):1038-1048.DOI: 10.1016/j.metabol.2015.12.012.
[5] Boursier J, Mueller O, Barret M,et al. The severity of nonalcoholic fatty liver disease is associated with gut dysbiosisand shift in the metabolic function of the gut microbiota[J].Hepatology,2016,63(3):764-775. DOI:10.1002/hep.28356.
[6] Honda K, Littman DR. The microbiome in infectious disease and inflammation[J].Annu Rev Immunol,2012,30:759-795. DOI:10.1146/annurev-immunol-020711-074937.
[7] Mouzaki M, Comelli EM, Arendt BM,et al. Intestinal microbiota in patients with nonalcoholic fatty liver disease[J].Hepatology,2013,58(1):120-127. DOI:10.1002/hep.26319.
[8] De Minicis S, Rychlicki C, Agostinelli L,et al. Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice[J].Hepatology,2014,59(5):1738-1749. DOI:10.1002/hep.26695.
[9] Yoshimoto S, Loo TM, Atarashi K,et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome[J].Nature,2013,499(7456):97-101. DOI:10.1038/nature12347.
[10] Lim JS, Mietus-Snyder M, Valente A,et al. The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome[J].Nat Rev Gastroenterol Hepatol,2010,7(5):251-264. DOI:10.1038/nrgastro.2010.41.
[11] David LA, Maurice CF, Carmody RN, et al. Diet rapidly and reproducibly alters the human gut microbiome[J].Nature,2014,505(7484):559-563. DOI:10.1038/nature12820.
[12] Tarantino G, Finelli C. Systematic review on intervention with prebiotics/probiotics in patients with obesity-related nonalcoholic fatty liver disease[J].Future Microbiol,2015,10(5):889-902. DOI:10.2217/fmb.15.13.
[13] Trenell MI. Sedentary behaviour, physical activity, and NAFLD: curse of the chair[J].J Hepatol,2015,63(5):1064-1065. DOI:10.1016/j.jhep.2015.08.009.
[14] Walker AW, Ince J, Duncan SH,et al. Dominant and diet-responsive groups of bacteria within the human colonic microbiota[J].ISME J,2011,5(2):220-230. DOI:10.1038/ismej.2010.118.
[15] Cani PD. When specific gut microbes reveal a possible link between hepatic steatosis and adipose tissue[J].J Hepatol,2014,61(1):5-6. DOI:10.1016/j.jhep.2014.04.006.
[16] Caesar R, Tremaroli V, Kovatcheva-Datchary P,et al. Crosstalk between gut microbiota and dietary lipids aggravates WAT inflammation through TLR signaling[J].Cell Metab,2015,22(4):658-668. DOI:10.1016/j.cmet.2015.07.026.
[17] Corbin KD, Zeisel SH. Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression[J].Curr Opin Gastroenterol,2012,28(2):159-165. DOI:10.1097/MOG.0b013e32834e7b4b.
[18] Neuschwander-Tetri BA, Loomba R, Sanyal AJ, et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis(FLINT): a multicentre, randomised, placebo-controlled trial[J].Lancet,2015,385(9972):956-965. DOI:10.1016/S0140-6736(14)61933-4.
[19] Mujico JR, Baccan GC, Gheorghe A,et al. Changes in gut microbiota due to supplemented fatty acids in diet-induced obese mice[J].Br J Nutr,2013,110(4):711-720. DOI:10.1017/S0007114512005612.
[20] Bozzetto L, Prinster A, Annuzzi G,et al. Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients[J].Diabetes Care,2012,35(7):1429-1435. DOI:10.2337/dc12-0033.
[21] Houghton D, Wilcox MD, Chater PI,et al. Biological activity of alginate and its effect on pancreatic lipase inhibition as apotential treatment for obesity[J].Food Hydrocoll,2015,49:18-24.DOI:10.1016/j.foodhyd.2015.02.019.
[22] Neyrinck AM, Possemiers S, Verstraete W,et al. Dietary modulation of clostridial cluster X Ⅳ a gut bacteria(Roseburia spp.)by chitin-glucan fiber improves host metabolic alterations induced by high-fat diet in mice[J].J Nutr Biochem,2012,23(1):51-59. DOI:10.1016/j.jnutbio.2010.10.008.
[23] Duncan SH, Lobley GE, Holtrop G,et al. Human colonic microbiota associated with diet, obesity and weight loss[J].Int J Obes(Lond),2008,32(11):1720-1724. DOI:10.1038/ijo.2008.155.
[24] Ferrere G, Leroux A, Wrzosek L, et al. Activation of kupffer cells is associated with a specific dysbiosis induced by fructose or high fat diet in mice[J].PLoS One,2016,11(1):e0146177. DOI:10.1371/journal.pone.0146177.
[25] Kiilerich P, Myrmel LS, Fjære E,et al. Effect of a long-term high-protein diet on survival, obesity development, and gut microbiota in mice[J].Am J Physiol Endocrinol Metab,2016,310(11):E886-E899. DOI:10.1152/ajpendo.00363.2015.
[26] Russell WR, Gratz SW, Duncan SH,et al. High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health[J].Am J Clin Nutr,2011,93(5):1062-1072. DOI:10.3945/ajcn.110.002188.

相似文献/References:

[1]曹涵,曲伸.过氧化物酶体增殖物活化受体与非酒精性脂肪性肝病[J].国际内分泌代谢杂志,2014,(06):404.[doi:10.3760/cma.j.issn.1673-4157.2014.06.012]
 Cao Han,Qu Shen..Peroxisome proliferator-activated receptors and non-alcoholic fatty liver diseases[J].International Journal of Endocrinology and Metabolism,2014,(04):404.[doi:10.3760/cma.j.issn.1673-4157.2014.06.012]
[2]胡雅琴,包玉倩.维生素D对非酒精性脂肪性肝病的保护作用[J].国际内分泌代谢杂志,2014,(06):408.[doi:10.3760/cma.j.issn.1673-4157.2014.06.013]
 Hu Yaqin,Bao Yuqian..Protective effect of vitamin D on non-alcoholic fatty liver disease[J].International Journal of Endocrinology and Metabolism,2014,(04):408.[doi:10.3760/cma.j.issn.1673-4157.2014.06.013]
[3]刘艳清 易秋艳 邵加庆.肠道菌群与肥胖和糖尿病的关系[J].国际内分泌代谢杂志,2015,(01):31.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.01.007]
 Liu Yanqing,Yi Qiuyan,Shao Jiaqing..Relationship between gut microbiota, obesity and diabetes[J].International Journal of Endocrinology and Metabolism,2015,(04):31.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.01.007]
[4]姚旻 赵爱源 张宏.肠道菌群与2型糖尿病[J].国际内分泌代谢杂志,2015,(01):35.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.01.008]
 Yao Min*,Zhao Aiyuan,Zhang Hong..Relationship between gut microbiota and type 2 diabetes[J].International Journal of Endocrinology and Metabolism,2015,(04):35.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.01.008]
[5]林天烨,方文军.肠道菌群与代谢性疾病的关系[J].国际内分泌代谢杂志,2014,(04):277.[doi:10.3760/cma.j.issn.1673-4157.2014.04.018]
 Lin Tianye*,Fang Wenjun..Relationship between microbiota and metabolic diseases[J].International Journal of Endocrinology and Metabolism,2014,(04):277.[doi:10.3760/cma.j.issn.1673-4157.2014.04.018]
[6]聂秀玲,李明珍,孙丽荣.高尿酸血症与非酒精性脂肪性肝病[J].国际内分泌代谢杂志,2016,36(02):89.[doi:10.3760/cma.j.issn.1673-4157.2016.02.004]
 Nie Xiuling,Li Mingzhen,Sun Lirong..Hyperuricemia and non-alcoholic fatty liver[J].International Journal of Endocrinology and Metabolism,2016,36(04):89.[doi:10.3760/cma.j.issn.1673-4157.2016.02.004]
[7]张洁,邸阜生.运动防治非酒精性脂肪性肝病的机制[J].国际内分泌代谢杂志,2016,36(06):404.[doi:10.3760/cma.j.issn.1673-4157.2016.06.12]
 Zhang Jie,Di Fusheng..Mechanism of exercise on non-alcoholic fatty liver disease[J].International Journal of Endocrinology and Metabolism,2016,36(04):404.[doi:10.3760/cma.j.issn.1673-4157.2016.06.12]
[8]张雅楠,郗光霞,杨翠萍,等.自噬在非酒精性脂肪性肝病中的变化及作用[J].国际内分泌代谢杂志,2017,37(01):11.[doi:10.3760/cma.j.issn.1673-4157.2017.01.03]
 Zhang Yanan*,Xi Guangxia,Yang Cuiping,et al.The change and function of autophagy in nonalcoholic fatty liver disease[J].International Journal of Endocrinology and Metabolism,2017,37(04):11.[doi:10.3760/cma.j.issn.1673-4157.2017.01.03]
[9]浮迎迎,刘超,蔡可英.肠道菌群与甲状腺稳态的关系[J].国际内分泌代谢杂志,2017,37(02):98.[doi:10.3760/cma.j.issn.1673-4157.2017.02.007]
 Fu Yingying*,Liu Chao,Cai Keying..Relationship between intestinal bacteria and thyroid homeostasis[J].International Journal of Endocrinology and Metabolism,2017,37(04):98.[doi:10.3760/cma.j.issn.1673-4157.2017.02.007]
[10]李博,苏青.晚期糖基化终末产物及其受体与非酒精性脂肪性肝病的 关系[J].国际内分泌代谢杂志,2017,37(03):192.[doi:10.3760/cma.j.issn.1673-4157.2017.03.013]
 Li Bo,Su Qing..Relationship between advanced glycation end-products and its receptor in nonalcoholic fatty liver diseases[J].International Journal of Endocrinology and Metabolism,2017,37(04):192.[doi:10.3760/cma.j.issn.1673-4157.2017.03.013]

备注/Memo

备注/Memo:
通信作者:刘超,Email:liuchao@nfmcn.com
更新日期/Last Update: 2017-07-30