[1]李博,苏青.晚期糖基化终末产物及其受体与非酒精性脂肪性肝病的 关系[J].国际内分泌代谢杂志,2017,37(03):192-194.[doi:10.3760/cma.j.issn.1673-4157.2017.03.013]
 Li Bo,Su Qing..Relationship between advanced glycation end-products and its receptor in nonalcoholic fatty liver diseases[J].International Journal of Endocrinology and Metabolism,2017,37(03):192-194.[doi:10.3760/cma.j.issn.1673-4157.2017.03.013]
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晚期糖基化终末产物及其受体与非酒精性脂肪性肝病的 关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年03期
页码:
192-194
栏目:
综述
出版日期:
2017-05-20

文章信息/Info

Title:
Relationship between advanced glycation end-products and its receptor in nonalcoholic fatty liver diseases
作者:
李博苏青
200092 上海交通大学医学院附属新华医院内分泌科
Author(s):
Li Bo Su Qing.
Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
关键词:
晚期糖基化终末产物 晚期糖基化终末产物受体 非酒精性脂肪性肝病
Keywords:
Advanced glycation end-products Receptor for advanced glycation end-products Nonalcoholic fatty liver diseases
DOI:
10.3760/cma.j.issn.1673-4157.2017.03.013
摘要:
晚期糖基化终末产物(AGE)是高血糖的标志物,能通过AGE受体(RAGE)发挥致病作用。研究发现,AGE/RAGE与非酒精性脂肪性肝病(NAFLD)的发展关系密切。AGE能增加肝脏的甘油三酯水平,促进单纯性脂肪肝(SFL)的发生,AGE/RAGE可诱导肝脏炎性反应,促进SFL向非酒精性脂肪性肝炎(NASH)发展,并能通过诱导活性氧簇的合成,活化肝脏星状细胞来引起肝纤维化。
Abstract:
Advanced glycation end-products(AGE)are biomarkers of hyperglycemia, the receptors for AGE(RAGE)are involved in AGE-induced pathogenesis. It has found that AGE/RAGE was closely associated with the development of nonalcoholic fatty liver diseases(NAFLD). AGE can increase the accumulation of hepatic triglycerides and promote the occurrence of simple fatty liver(SFL). AGE/RAGE induces hepatic inflammation and accelerates the development of SLF to nonalcoholic steatohepatitis(NASH), and induces hepatic cirrhosis by promoting the synthesis of reactive oxygen species, activating hepatic stellate cells.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81370935,81500663); 新华医院院基金(15YJ06) 通信作者:苏青,Email: suqing139@126.com
更新日期/Last Update: 2017-05-20