[1]聂秀玲,李明珍,孙丽荣.高尿酸血症与非酒精性脂肪性肝病[J].国际内分泌代谢杂志,2016,36(02):89-91.[doi:10.3760/cma.j.issn.1673-4157.2016.02.004]
 Nie Xiuling,Li Mingzhen,Sun Lirong..Hyperuricemia and non-alcoholic fatty liver[J].International Journal of Endocrinology and Metabolism,2016,36(02):89-91.[doi:10.3760/cma.j.issn.1673-4157.2016.02.004]
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高尿酸血症与非酒精性脂肪性肝病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年02期
页码:
89-91
栏目:
高尿酸血症/痛风相关代谢性疾病专栏
出版日期:
2016-03-20

文章信息/Info

Title:
Hyperuricemia and non-alcoholic fatty liver
作者:
聂秀玲李明珍孙丽荣
300070 天津医科大学代谢病医院糖尿病痛风科,天津医科大学代谢病医院内分泌研究所,卫生部激素与发育重点实验室, 天津市代谢性疾病重点实验室
Author(s):
Nie Xiuling Li Mingzhen Sun Lirong.
Department of Diabetes and Gout,Key Laboratory of Hormones and Development(Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin
关键词:
高尿酸血症 非酒精性脂肪性肝病 炎症
Keywords:
Hyperuricemia Non-alcoholic fatty liver Inflammation
DOI:
10.3760/cma.j.issn.1673-4157.2016.02.004
摘要:
非酒精性脂肪性肝病是由于肝脏中脂肪过度沉积,诱发炎性反应以及氧化应激损伤的一组疾病。而尿酸是人类嘌呤代谢的终产物,在体内起到抗氧化、调节免疫功能等生理作用。越来越多的证据表明高尿酸血症与非酒精性脂肪性肝病有关。不论是横断面研究还是前瞻性研究均显示高尿酸血症是非酒精性脂肪性肝病的独立危险因素。高尿酸血症可成为机体的致炎因子,诱导胰岛素抵抗,激发炎性反应信号通路,诱导炎性因子的产生,导致肝细胞中脂肪的积聚和炎性损伤。降尿酸治疗可对肝脏起到保护作用,可能成为非酒精性脂肪性肝病的治疗手段。
Abstract:
Non-alcoholic fatty liver disease(NAFLD)is a state of intrahepatic fat accumulation, which induces inflammatory reaction and oxidative stress. Uric acid is the end product of endogenous purines degration, which can play antioxidant role and regulate immunity. A growing number of evidence indicates that hyperuricemia is associated with NAFLD. Both cross-sectional and prospective studies indicated that hyperuricemia was the risk factor of NAFLD.Hyperuricemia can become proinflammatory factors, inducing insulin resistance, stimulating infammatory signal pathway, and leading to fatty accumulation in the liver. Hypouricemia therapy plays protective role in the liver,and may become a therapeutic target of NAFLD.

参考文献/References:

[1] Masarone M, Federico A, Abenavoli L,et al. Non alcoholic fatty liver: epidemiology and natural history[J].Rev Recent Clin Trials,2014,9(3):126-133.
[2] Sung KC, Ryan MC, Kim BS,et al. Relationships between estimates of adiposity, insulin resistance, and nonalcoholic fatty liver disease in a large group of nondiabetic Korean adults[J]. Diabetes Care, 2007, 30(8):2113-2118.
[3] Grassi D, Ferri L, Desideri G, et al. Chronic hyperuricemia, uric acid deposit and cardiovascular risk [J]. Curr Pharm Des,2013,19:4930-4937.
[4] Lonardo A, Loria P, Leonardi F,et al. Fasting insulin and uric acid levels but not indices of iron metabolism are independent predictors of non-alcoholic fatty liver disease.A case-control study[J]. Dig Liver Dis,2002,34(3):204-211.
[5] Lee S, Jin Kim Y, Yong Jeon T,et al. Obesity is the only independent factor associated with ultrasound-diagnosed non-alcoholic fatty liver disease: a cross-sectional case-control study[J]. Scand J Gastroenterol,2006,41(5):566-572.
[6] Li Y, Xu C, Yu C,et al. Association of serum uric acid level with non-alcoholic fatty liver disease: a cross-sectional study[J]. J Hepatol,2009,50(5):1029-1034.DOI:10.1016/j.jhep.2008.11.021.
[7] Xie Y, Wang M, Zhang Y,et al. Serum uric acid and non-alcoholic fatty liver disease in non-diabetic Chinese men[J].PLoS One,2013,8(7):e67152.DOI:10.1371/journal.pone.0067152. Print 2013.
[8] Lin H, Li Q, Liu X,et al. Liver fat content is associated with elevated serum uric acid in the Chinese middle-aged and elderly populations: Shanghai Changfeng Study[J]. PLoS One, 2015,10(10): e0140379.DOI:10.1371/journal.pone.0140379. eCollection 2015.
[9] Cai W, Wu X, Zhang B,et al. Serum uric acid levels and non-alcoholic fatty liver disease in Uyghur and Han ethnic groups in northwestern China[J].Arq Bras Endocrinol Metabol,2013,57(8):617-622.
[10] Sirota JC, McFann K, Targher G,et al. Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: liver ultrasound data from the National Health and Nutrition Examination Survey[J].Metabolism,2013,62(3):392-399.DOI:10.1016/j. metabol. 2012.08.013.
[11] Sogabe M, Okahisa T, Taniguchi T,et al. Light alcohol consumption plays a protective role against non-alcoholic fatty liver disease in Japanese men with metabolic syndrome[J].Liver Int,2015,35(6):1707-1714.DOI:10.1111/liv.12754.
[12] Petta S, Cammà C, Cabibi D,et al. Hyperuricemia is associated with histological liver damage in patients with non-alcoholic fatty liver disease[J].Aliment Pharmacol Ther,2011,34(7):757-766. DOI: 10.1111/j.1365-2036.2011.04788.x.
[13] Lee JW, Cho YK, Ryan M,et al. Serum uric acid as a predictor for the development of nonalcoholic fatty liver disease in apparently healthy subjects: a 5-year retrospective cohort study[J].Gut Liver, 2010,4(3):378-383. DOI: 10.5009/gnl.2010.4.3.378.
[14] Xu C, Yu C, Xu L,et al. High serum uric acid increases the risk for nonalcoholic fatty liver disease: a prospective observational study[J].PLoS One,2010,5(7):e11578. DOI: 10.1371/journal.pone.0011578.
[15] Xu C, Wan X, Xu L,et al. Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia: one stone hits two birds[J].J Hepatol,2015,62(6):1412-1419.DOI:10.1016/j.jhep.2015.01.019.
[16] Nakatsu Y, Seno Y, Kushiyama A,et al.The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model[J]. Am J Physiol Gastrointest Liver Physiol,2015,309(1):G42-G51.DOI:10.1152/ajpgi.00443.2014.
[17] Li X, Huang W, Gu J,et al. SREBP-1c overactivates ROS-mediated hepatic NF-κB inflammatory pathway in dairy cows with fatty liver[J].Cell Signal,2015,27(10):2099-2109. DOI: 10.1016/j.cellsig.2015.07.011.
[18] Choi YJ, Shin HS, Choi HS,et al. Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes[J].Lab Invest, 2014,94(10):1114-1125.DOI:10.1038/labinvest.2014.98.
[19] Lanaspa MA, Sanchez-Lozada LG, Choi YJ,et al. Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver[J].J Biol Chem,2012,287(48):40732-40744. DOI: 10.1074/jbc.M112.399899.
[20] Xu C. Hyperuricemia and nonalcoholic fatty liver disease: from bedside to bench and back[J].Hepatol Int, 2015,[Epub ahead of print].
[21] Zhang JX, Zhang YP, Wu QN,et al. Uric acid induces oxidative stress via an activation of the renin-angiotensin system in 3T3-L1 adipocytes[J]. Endocrine,2015,48(1):135-142. DOI: 10.1007/s12020-014-0239-5.

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更新日期/Last Update: 2016-03-20