[1]何玮婧,陈立勇,赵家军.促甲状腺激素与肥胖[J].国际内分泌代谢杂志,2014,(04):260-262，266.[doi:10.3760/cma.j.issn.1673-4157.2014.04.013]
　He Weijing,Chen Liyong,Zhao Jiajun..Thyroid stimulating hormone and obesity[J].International Journal of Endocrinology and Metabolism,2014,(04):260-262，266.[doi:10.3760/cma.j.issn.1673-4157.2014.04.013]
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促甲状腺激素与肥胖()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年04期
页码:
260-262，266
栏目:
甲状腺疾病专栏
出版日期:
2014-08-31

文章信息/Info

Title:
Thyroid stimulating hormone and obesity
作者:
何玮婧; 陈立勇; 赵家军
作者单位：250021　济南，山东大学附属省立医院内分泌科 　　
Author(s):
He Weijing; Chen Liyong; Zhao Jiajun.
Department of Endocrinology，Provincial Hospital Affiliated to Shandong University，Jinan 250021，China Corresponding author：Zhao Jiajun，Email:jjzhao@medmail.com.cn
关键词:
促甲状腺激素; 肥胖; 脂肪细胞
Keywords:
Thyroid stimulating hormone; Obesity; Adipocytes
DOI:
10.3760/cma.j.issn.1673-4157.2014.04.013
摘要:
肥胖患者常出现甲状腺功能异常，这种异常在体重减轻后有所恢复，而甲状腺功能的异常又可引起脂肪堆积或体重增加。研究发现，人类脂肪细胞表达功能性的促甲状腺激素受体（TSHR），促甲状腺激素（TSH）可能作用于表达TSHR的脂肪细胞，调节脂肪细胞的生长、增殖、分化及脂肪因子的分泌。目前，TSH与体重指数、腰臀比、腰围等的关系尚存争议，但较多研究肯定了TSH与大部分肥胖相关参数存在正相关。
Abstract:
Obese patients are often accompanied by thyroid dysfunction which would be recovered after weight loss. Besides， thyroid dysfunction may cause the accumulation of body fat or weight gain. Studies have found that human adipocytes express functional thyroid stimulating hormone（TSH） receptor （TSHR） and TSH may regulate the growth，proliferation，differentiation and the secretion of adipokines in adipocytes through TSHR. Although the association between TSH and obesity-related parameters such as body mass index，waist hip ratio，waist circumference is remain disputed， several investigations have demonstrated a positive correlation between TSH and most anthropometric measures.

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备注/Memo

备注/Memo:
基金项目：国家重点基础研究发展计划项目（2012CB5249）；国家自然科学基金资助项目（81230018，8270869，81170794,30971409）； 山东省科学技术发展计划项目（2012GSF11824，2012GSF11833） 通信作者：赵家军，Email:jjzhao@medmail.com.cn
更新日期/Last Update: 2014-07-20