[1]李秀娟,刘红梅.IgG4相关桥本甲状腺炎的研究进展[J].国际内分泌代谢杂志,2014,(04):257-259.[doi:10.3760/cma.j.issn.1673-4157.2014.04.012]
　Li Xiujuan,Liu Hongmei..Recent progress of IgG4-related Hashimoto's thyroiditis[J].International Journal of Endocrinology and Metabolism,2014,(04):257-259.[doi:10.3760/cma.j.issn.1673-4157.2014.04.012]
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IgG4相关桥本甲状腺炎的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年04期
页码:
257-259
栏目:
甲状腺疾病专栏
出版日期:
2014-08-31

文章信息/Info

Title:
Recent progress of IgG4-related Hashimoto's thyroiditis
作者:
李秀娟; 刘红梅
作者单位: 400015　重庆医科大学附属第一医院第一分院内分泌科
Author(s):
Li Xiujuan; Liu Hongmei.
Department of Endocrinology，The Frist Branch，The First Affiliated Hospital of Chongqing Medical University，Chongqing 400015，China
关键词:
IgG4; 桥本甲状腺炎; 纤维化
Keywords:
IgG4; Hashimoto's thyroiditis; Fibrosis
DOI:
10.3760/cma.j.issn.1673-4157.2014.04.012
摘要:
研究发现部分桥本甲状腺炎患者的甲状腺组织中有大量IgG4阳性浆细胞浸润，提示其可能是一种IgG4相关性疾病。根据免疫组化染色结果可以将桥本甲状腺炎分为IgG4相关型和非IgG4相关型；IgG4相关型桥本甲状腺炎患者甲状腺组织表现出明显的间质纤维化、淋巴细胞浸润以及滤泡细胞破坏；区分桥本甲状腺炎不同亚型，有利于早期发现和治疗重症桥本甲状腺炎患者。
Abstract:
Studies show that there are large numbers of IgG4-positive plasma cells in the thyroid of Hashimoto's thyroiditis（HT） patients，which suggesting that this type of HT might have a close relationship with IgG4-related disease. Based on the immunostaining results for IgG4，patients with HT can be divided into IgG4-related type and non-IgG4 related. Histopathological examination of thyroid in patients with IgG4-related HT shows a higher grade of stromal fibrosis，lymphoplasmacytic infiltration and follicular cell degen-eration. Classification of HT subtypes is beneficial to early detection and treatment of severe HT patients.

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更新日期/Last Update: 2014-07-20