[1]刘正云,张克勤.妊娠合并甲状腺过氧化物酶抗体阳性状态对妊娠结局及后代的影响[J].国际内分泌代谢杂志,2014,(04):253-256.[doi:10.3760/cma.j.issn.1673-4157.2014.04.011]
 Effects of positive thyroid peroxidase antibody on pregnancy outcome and offspring.Effects of positive thyroid peroxidase antibody on pregnancy outcome and offspring[J].International Journal of Endocrinology and Metabolism,2014,(04):253-256.[doi:10.3760/cma.j.issn.1673-4157.2014.04.011]
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妊娠合并甲状腺过氧化物酶抗体阳性状态对妊娠结局及后代的影响()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年04期
页码:
253-256
栏目:
甲状腺疾病专栏
出版日期:
2014-08-31

文章信息/Info

Title:
Effects of positive thyroid peroxidase antibody on pregnancy outcome and offspring
作者:
刘正云张克勤
作者单位:200030 上海交通大学医学院附属国际和平妇幼保健院(刘正云);200065 上海,同济大学医学院附属同济医院内分泌科(张克勤)   
Author(s):
Effects of positive thyroid peroxidase antibody on pregnancy outcome and offspring
*International Peace Maternity and Children Healthcare Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200030,China Corresponding author:Zhang Keqin,Email:keqzhang2007@126.com
关键词:
妊娠甲状腺过氧化物酶抗体妊娠结局后代
Keywords:
PregnancyThyroid peroxidase antibodyPregnancy outcomesOffspring
DOI:
10.3760/cma.j.issn.1673-4157.2014.04.011
摘要:
妊娠期甲状腺功能异常特别是甲状腺功能减退症对妊娠妇女和胎儿均可造成危害,妊娠期甲状腺过氧化物酶抗体(TPOAb)阳性也与妊娠不良结局及其后代发育不良有关。研究显示,TPOAb阳性与妊娠妇女流产、早产、胎膜早破及产后甲状腺炎发病风险增加相关。TPOAb 阳性母亲的后代智力评分和运动能力评分均低于TPOAb 阴性母亲的后代。目前TPOAb阳性与妊娠不良结局相关的因果关系及病理机制尚不明确,有待进一步研究。
Abstract:
Gestational thyroid dysfunction especially hypothyroidism can affect pregnant women and fetus. Thyroid peroxidase antibody(TPOAb) positive state is associated with adverse pregnancy outcomes and the dysplasia of their offspring. Studies show that TPOAb positive state is related with pregnant women abortion, premature delivery,premature rupture of membranes and increased risk of postpartum thyroiditis in pregnant women.The offspring's intelligence scores and sports scores of TPOAb positive mother are lower than those of TPOAb negative mother. The related mechanisms of the relationship between TPOAb positive state and adverse pregnancy outcomes is not clear,needs be further studied.

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备注/Memo

备注/Memo:
通信作者:张克勤,Email:keqzhang2007@126.com
更新日期/Last Update: 2014-07-20