[1]张倩倩,陈丽,王国娟.血尿酸/肌酐比值与2型糖尿病患者颈动脉斑块稳定性因素的相关性研究[J].国际内分泌代谢杂志,2024,44(03):167-171.[doi:10.3760/cma.j.cn121383-20221206-12012]
　Zhang Qianqian,Chen Li,Wang Guojuan..Correlation between serum uric acid to creatinine ratio and stability factors of carotid plaque in type 2 diabetes patients[J].International Journal of Endocrinology and Metabolism,2024,44(03):167-171.[doi:10.3760/cma.j.cn121383-20221206-12012]
点击复制

血尿酸/肌酐比值与2型糖尿病患者颈动脉斑块稳定性因素的相关性研究()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
44
期数:
2024年03期
页码:
167-171
栏目:
论著
出版日期:
2024-05-20

文章信息/Info

Title:
Correlation between serum uric acid to creatinine ratio and stability factors of carotid plaque in type 2 diabetes patients
作者:
张倩倩; 陈丽; 王国娟
合肥市第一人民医院滨湖院区内分泌科,合肥 230000
Author(s):
Zhang Qianqian;  Chen Li;  Wang Guojuan.
Department of Endocrinolongy, Binhu District of Hefei First People's Hospital, Hefei 230000, China
关键词:
2型糖尿病;  颈动脉斑块;  血尿酸/肌酐比值
Keywords:
Type 2 diabetes;  Carotid plaque;  Serum uric acid to creatinine ratio
DOI:
10.3760/cma.j.cn121383-20221206-12012
摘要:
目的 探讨血尿酸/肌酐比值(SUA/Cr)与2型糖尿病(T2DM)患者颈动脉斑块稳定性的相关性,开发一种新的评估量表,用于临床快速评估T2DM患者颈动脉斑块的稳定性。方法 收集2015年1月至2022年2月T2DM合并颈动脉斑块的住院患者518例,收集患者的一般资料及临床检验等指标,完善颈动脉超声检查。根据超声特征将患者分为斑块稳定组(262例)和易损斑块组(256例)。计量资料两组间比较采用独立样本t检验、Mann Whitney U检验。计数资料两组间比较采用χ2检验。二元Logistic回归分析颈动脉斑块不稳定的独立危险因素。将独立危险因素绘制受试者工作特征(ROC)曲线,并计算曲线下面积(AUC)。对易损斑块组的患者,进行颈动脉斑块数目和颈动脉斑块回声评分,分析SUA/Cr与颈动脉斑块稳定性的相关性。在二元Logistic回归模型中,将所有独立危险因素按照OR值来评分,建立评价量表。结果 易损斑块组的SUA/Cr明显高于斑块稳定组,差异有统计学意义(P<0.01),斑块不稳定的风险随SUA/Cr的增加而增加(OR=3.121,95% CI 2.376～4.099,P<0.01)。ROC曲线示SUA/Cr临界值为4.899,AUC为0.783。所有数据经评价量表检验,≥6分为最佳截断值。结论 在T2DM患者中,SUA/Cr与颈动脉斑块的稳定性相关,SUA/Cr可用于指示颈动脉斑块不稳定性的风险。新的评分量表是预测颈动脉斑块稳定性的可靠指标。
Abstract:
Objective To explore the correlation between the serum uric acid to creatinine ratio(SUA/Cr)and the stability of carotid plaque in patients with type 2 diabetes(T2DM), and to develop a new evaluation scale for rapid clinical evaluation of the stability of carotid plaque in patients with T2DM.Methods 518 inpatients with T2DM and carotid plaque from January 2015 to February 2022 were collected. Collect general information and clinical testing indicators of patients, while improving carotid artery ultrasound examination. According to the ultrasonic characteristics, the patients were divided into plaque stable group(262 cases)and plaque unstable group(256 cases). The measurement data between the two groups were compared by independent sample t test and Mann-Whitney U test. The counting data were compared between the two groups χ2 Inspection. The independent risk factors of carotid plaque instability were analyzed by binary logistic regression. Draw the ROC curve for independent risk factors, and calculate the area under the curve(AUC). For patients with plaque instability, carotid plaque number score and carotid plaque echo score were performed respectively to analyze the correlation between UA/Cr and carotid plaque stability. Finally, in the binary logistic regression model, all independent risk factors are scored according to the OR value to establish an evaluation scale.Results SUA/Cr in the plaque unstable group was significantly higher than that in the plaque stable group(P<0.01). The risk of plaque instability increased with the increase of SUA/Cr(OR=3.121, 95% CI 2.376～ 4.099, P<0.01). The ROC curve shows that the critical value of SUA/Cr is 4.899 and AUC is 0.783. All data were tested by the evaluation scale, and ≥ 6 points was the best cut-off value.Conclusions In T2DM patients, SUA/Cr is related to the stability of carotid plaque, and SUA/Cr can be used to indicate the risk of carotid plaque instability. The new scoring standard is a reliable index to predict the stability of carotid plaque.

参考文献/References:

[1] Biscetti F,Tinelli G,Rando MM,et al.Correction to:association between carotid plaque vulnerability and high mobility group box1 serum levels in a diabetic population[J].Cardiovasc Diabetol,2021,20(1):184.DOI:10.1186/s12933-021-01376-6.
[2] Kamtchum-Tatuene J,Nomani AZ,Falcione S,et al.Non-stenotic carotid plaques in embolic stroke of unknown source[J].Front Neurol,2021,12:719329.DOI:10.3389/fneur.2021.719329.
[3] Cires-Drouet RS,Mozafarian M,Ali A,et al.Imaging of high-risk carotid plaques:ultrasound[J].Semin Vasc Surg,2017,30(1):44-53.DOI:10.1053/j.semvascsurg.2017.04.010.
[4] Wang R,Zhong Y,Zhou Q,et al.Relationship between uric acid level and severity of acute primary cerebral infarction:a cross-sectional study[J].Biomed Res Int,2020,2020:2310307.DOI:10.1155/2020/2310307.
[5] Jankowski J,Floege J,Fliser D,et al.Cardiovascular disease in chronic kidney disease:pathophysiological insights and therapeutic options[J].Circulation,2021,143(11):1157-1172.DOI:10.1161/CIRCULATIONAHA.120.050686.
[6] Li M,Gu L,Yang J,et al.Serum uric acid to creatinine ratio correlates with β-cell function in type 2 diabetes[J].Diabetes Metab Res Rev,2018,34(5):e3001.DOI:10.1002/dmrr.3001.
[7] Büyükbayram G,Yüceer Ö,Oymak FS.The relationship between serum uric acid levels and early mortality in chronic obstructive pulmonary disease cases during exacerbation[J].Sarcoidosis Vasc Diffuse Lung Dis,2022,39(2):e2022014.DOI:10.36141/svdld.v39i2.12127.
[8] Gray-Weale AC,Graham JC,Burnett JR,et al.Carotid artery atheroma:comparison of preoperative B-mode ultrasound appearance with carotid endarterectomy specimen pathology[J].J Cardiovasc Surg(Torino),1988,29(6):676-681.
[9] Barrett HE,Van der Heiden K,Farrell E,et al.Calcifications in atherosclerotic plaques and impact on plaque biomechanics[J].J Biomech,2019,87:1-12.DOI:10.1016/j.jbiomech.2019.03.005.
[10] Chen Y,Xing H,Wen J,et al.Three-dimensional ultrasound imaging:an effective method to detect the effect of moderate intensity statin treatment in slowing carotid plaque progression[J].J Clin Ultrasound,2021,49(7):731-740.DOI:10.1002/jcu.23013.
[11] Saito Y,Tanaka A,Node K,et al.Uric acid and cardiovascular disease:a clinical review[J].J Cardiol,2021,78(1):51-57.DOI:10.1016/j.jjcc.2020.12.013.
[12] Ong G,Davis WA,Davis TM.Serum uric acid does not predict cardiovascular or all-cause mortality in type 2 diabetes:the fremantle diabetes study[J].Diabetologia,2010,53(7):1288-1294.DOI:10.1007/s00125-010-1735-7.
[13] Kawamoto R,Ninomiya D,Kikuchi A,et al.Serum uric acid to creatinine ratio is a useful predictor of renal dysfunction among diabetic persons[J].Diabetes Metab Syndr,2019,13(3):1851-1856.DOI:10.1016/j.dsx.2019.04.023.
[14] Tao J,Shen X,Li J,et al.Serum uric acid to creatinine ratio and metabolic syndrome in postmenopausal Chinese women[J].Medicine(Baltimore),2020,99(17):e19959.DOI:10.1097/MD.0000000000019959.
[15] Zuo T,Liu X,Jiang L,et al.Hyperuricemia and coronary heart disease mortality:a meta-analysis of prospective cohort studies[J].BMC Cardiovasc Disord,2016,16(1):207.DOI:10.1186/s12872-016-0379-z.
[16] Yang Y,Zhang X,Jin Z,et al.Association of serum uric acid with mortality and cardiovascular outcomes in patients with hypertension:a meta-analysis[J].J Thromb Thrombolysis,2021,52(4):1084-1093.DOI:10.1007/s11239-021-02453-z.
[17] Marchio P,Guerra-Ojeda S,Vila JM,er al.Targeting early atherosclerosis:a focus on oxidative stress and inflammation[J].Oxid Med Cell Longev,2019,2019:8563845.DOI:10.1155/2019/8563845.
[18] Kimura Y,Tsukui D,Kono H.Uric acid in inflammation and the pathogenesis of atherosclerosis[J].Int J Mol Sci,2021,22(22):12394.DOI:10.3390/ijms222212394.

相似文献/References:

[1]曾静波,王姮.2型糖尿病与自身免疫反应[J].国际内分泌代谢杂志,2007,(04):259.
[2]朱素君,谢锦桃,刘军,等.二甲双胍：2型糖尿病治疗的基础药[J].国际内分泌代谢杂志,2007,(04):280.
[3]刘艳清 易秋艳 邵加庆.肠道菌群与肥胖和糖尿病的关系[J].国际内分泌代谢杂志,2015,(01):31.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.007]
　Liu Yanqing,Yi Qiuyan,Shao Jiaqing..Relationship between gut microbiota, obesity and diabetes[J].International Journal of Endocrinology and Metabolism,2015,(03):31.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.007]
[4]姚旻 赵爱源 张宏.肠道菌群与2型糖尿病[J].国际内分泌代谢杂志,2015,(01):35.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.008]
　Yao Min*,Zhao Aiyuan,Zhang Hong..Relationship between gut microbiota and type 2 diabetes[J].International Journal of Endocrinology and Metabolism,2015,(03):35.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.008]
[5]赵丽娟,徐宽枫,杨涛,等.SLC30A8和PTPRD基因多态性与南京地区中老年人群2型糖尿病的相关性研究[J].国际内分泌代谢杂志,2015,(03):145.[doi:10.3760/cma.j.issn.1673-4157.2015.03.001]
　Zhao Lijuan*,Xu Kuanfeng,Yang Tao,et al.Relationship between SLC30A8 and PTPRD gene polymorphisms and type 2 diabetes in middle aged and elderly people in Nanjing area[J].International Journal of Endocrinology and Metabolism,2015,(03):145.[doi:10.3760/cma.j.issn.1673-4157.2015.03.001]
[6]王洁,何媛,于珮.糖尿病肾病的相关危险因素分析[J].国际内分泌代谢杂志,2015,(03):153.[doi:10.3760/cma.j.issn.1673-4157.2015.03.003]
　Wang Jie*,He Yuan,Yu Pei..Risk factors of diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(03):153.[doi:10.3760/cma.j.issn.1673-4157.2015.03.003]
[7]刘帅,张萍,方毅,等.2型糖尿病合并无症状冠状动脉钙化的相关危险因素分析[J].国际内分泌代谢杂志,2015,(03):158.[doi:10.3760/cma.j.issn.1673-4157.2015.03.004]
　Liu Shuai*,Zhang Ping,Fang Yi,et al.Analysis of the risk factors related with asymptomatic coronary calcification for type 2 diabetic patients[J].International Journal of Endocrinology and Metabolism,2015,(03):158.[doi:10.3760/cma.j.issn.1673-4157.2015.03.004]
[8]徐庆海,马颖,李铁马.2型糖尿病患者高甘油三酯血症-腰围表型与甲状腺功能异常的关系[J].国际内分泌代谢杂志,2015,(04):222.[doi:10.3760/cma.j.issn.1673-4157.2015.04.002]
　Xu Qinghai,Ma Ying,Li Tiema..Association of hypertriglyceridaemic-waist phenotype with thyroid dysfunction in patients with type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2015,(03):222.[doi:10.3760/cma.j.issn.1673-4157.2015.04.002]
[9]潘道延,沈洁,朱筱,等.利格列汀对2型糖尿病大鼠代谢性内毒素血症的影响[J].国际内分泌代谢杂志,2015,(04):230.[doi:10.3760/cma.j.issn.1673-4157.2015.04.004]
　Pan Daoyan,Shen Jie,Zhu Xiao,et al.Effects of linagliptin on metabolic endotoxemia in type 2 diabetic rats[J].International Journal of Endocrinology and Metabolism,2015,(03):230.[doi:10.3760/cma.j.issn.1673-4157.2015.04.004]
[10]黄桥,白洁,杜洪泉.一种新的脂肪细胞因子——cartonectin[J].国际内分泌代谢杂志,2015,(04):265.[doi:10.3760/cma.j.issn.1673-4157.2015.04.014]
　Huang Qiao*,Bai Jie,Du Hongquan..A novel adipokine--cartonectin[J].International Journal of Endocrinology and Metabolism,2015,(03):265.[doi:10.3760/cma.j.issn.1673-4157.2015.04.014]
[11]王继政 刘尚全 黄婷 江旭 张梦夏 许莉.血糖波动与颈动脉内膜中层厚度增加的 糖尿病患者形成斑块的相关性研究[J].国际内分泌代谢杂志,2020,40(03):150.[doi:10.3760/cma.j.issn.1673-4157.2020.03.002]
　Wang Jizheng,Liu Shangquan,Huang Ting,et al.Correlation between glycemic fluctuation and carotid artery plaque in patients with type 2 diabetes mellitus with abnormal carotid intima-media thickness[J].International Journal of Endocrinology and Metabolism,2020,40(03):150.[doi:10.3760/cma.j.issn.1673-4157.2020.03.002]

备注/Memo

备注/Memo:
通信作者:王国娟,Email:dfwangguojuan@126.com
更新日期/Last Update: 2024-05-30