[1]张伊桐,佟雪巍,徐宇欣,等.2型糖尿病患者静息代谢率与糖尿病视网膜病变的关系[J].国际内分泌代谢杂志,2023,43(06):464-468.[doi:10.3760/cma.j.cn121383-20220724-07049]
 Zhang Yitong,Tong Xuewei,Xu Yuxin,et al.Relationship between resting metabolic rate and diabetic retinopathy in patients with type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2023,43(06):464-468.[doi:10.3760/cma.j.cn121383-20220724-07049]
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2型糖尿病患者静息代谢率与糖尿病视网膜病变的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年06期
页码:
464-468
栏目:
论著
出版日期:
2023-11-20

文章信息/Info

Title:
Relationship between resting metabolic rate and diabetic retinopathy in patients with type 2 diabetes mellitus
作者:
张伊桐佟雪巍徐宇欣浦胜丹高昕媛
哈尔滨医科大学附属第一医院内分泌科,哈尔滨 150001
Author(s):
Zhang Yitong Tong Xuewei Xu Yuxin Pu Shengdan Gao Xinyuan.
Department of Endocrinology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
关键词:
2型糖尿病 糖尿病视网膜病变 静息代谢率预测方程
Keywords:
Type 2 diabetes mellitus Diabetes retinopathy Resting metabolic rate prediction equation
DOI:
10.3760/cma.j.cn121383-20220724-07049
摘要:
目的 探讨2型糖尿病(T2DM)患者静息代谢率(RMR)与糖尿病视网膜病变(DR)的相关性。方法 选取586例T2DM患者,分为无DR(NDR)组、轻度至中度非增殖性DR(NPDR)组和视力威胁性DR(VTDR)组。根据Mifflin-St Jeor公式计算静息代谢率(RMR)。观察不同Mifflin-RMR水平患者的临床特点。采用二元和有序logistic回归分析Mifflin-RMR与DR之间的关系。结果 VTDR组Mifflin-RMR显著高于轻度至中度NPDR组和NDR组,而轻度至中度NPDR组Mifflin-RMR也显著高于NDR组(P均<0.001)。在控制混杂变量后,与Mifflin-RMR第一分位数患者相比,第四分位数患者发生DR的风险明显增加(OR=17.763,95% CI: 8.017~39.356,P<0.001)。此外,Mifflin-RMR升高与DR严重程度相关(OR=13.447,95% CI: 6.936~25.971,P<0.001)。结论 在T2DM患者中,RMR与DR患病及严重程度相关。
Abstract:
Objective Aimed to investigate the correlationbetween resting metabolic rate(RMR)and diabetic retinopathy(DR)in patients with type 2 diabetes.Methods 586 patients with type 2 diabetes were selected and divided into no DR(NDR), mild to moderate non proliferative DR(NPDR)and vision threatening DR(VTDR). Calculate resting metabolic rate(RMR)according to Mifflin St Jeor formula. Observe the clinical characteristics of patients with different Mifflin-RMR levels. Binary and ordered logistic regression were used to analyze the relationship between Mifflin-RMR and DR.Results Mifflin-RMR was significantly higher in the VTDR group than in the mild to moderate NPDR and NDR groups, while Mifflin-RMR was also significantly higher in the mild to moderate NPDR group than in the NDR group(all P<0.001). After controlling for confounding variables,Subjects in the fourth Mifflin-RMR quartile had a significantly increased risk of DR compared to those in the first quartile(OR=17.763, 95% CI: 8.017-39.356,P<0.001). In addition, elevated Mifflin-RMR was associated with DR severity(OR=13.447, 95% CI: 6.936-25.971, P<0.001).Conclusion In patients with type 2 diabetes, RMR is associated with the prevalence and severity of DR.

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备注/Memo

备注/Memo:
基金项目:黑龙江省自然科学基金项目(LH2023H024)
通信作者:高昕媛,Email:m15124768260@163.com
更新日期/Last Update: 2023-12-30