[1]韦晓,张少红,孙烁烁,等.肠道菌群:口服降糖药物有效性和安全性的重要靶点[J].国际内分泌代谢杂志,2023,43(01):14-17.[doi:10.3760/cma.j.cn121383-20210915-09040]
 Wei Xiao,Zhang Shaohong,Sun Shuoshuo,et al.Gut microbiota: the important target of efficiency and safety of oral hypoglycemic agents[J].International Journal of Endocrinology and Metabolism,2023,43(01):14-17.[doi:10.3760/cma.j.cn121383-20210915-09040]
点击复制

肠道菌群:口服降糖药物有效性和安全性的重要靶点()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年01期
页码:
14-17
栏目:
肠道菌群与代谢性疾病专题
出版日期:
2023-01-20

文章信息/Info

Title:
Gut microbiota: the important target of efficiency and safety of oral hypoglycemic agents
作者:
韦晓张少红孙烁烁陈国芳刘超
南京中医药大学附属中西医结合医院,江苏省中医药研究院,南京 210028
Author(s):
Wei Xiao Zhang Shaohong Sun Shuoshuo Chen Guofang Liu Chao.
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China
关键词:
2型糖尿病 口服降糖药物 肠道菌群
Keywords:
Type 2 diabetes Oral hypoglycemic agents Gut microbiota
DOI:
10.3760/cma.j.cn121383-20210915-09040
摘要:
药物治疗是控制和逆转2型糖尿病的主要手段之一,常用的口服降糖药物(OHA)包括二甲双胍、α-糖苷酶抑制剂、二肽基肽酶4抑制剂、钠-葡萄糖协同转运蛋白2抑制剂和中草药等,其作用机制各不相同。肠道菌群是降糖药物的重要作用靶点,多种OHA可通过调节肠道菌群,降低细菌脂多糖含量,保护肠道粘膜屏障完整性,增加短链脂肪酸的生成,影响胆汁酸循环,从而降低炎症反应,缓解胰岛素抵抗,保护胰岛β细胞功能,发挥改善代谢功能的作用。
Abstract:
Oral hypoglycemic agents(OHA)are one of the main methods to control and reverse type 2 diabetes. Commonly used OHA include metformin, α-glycosidase inhibitors, DPP-4 inhibitors, SGLT2 inhibitors, herbal medicines and so on with different mechanisms. Mounting evidence has been found that gut microbiota is an important target of these drugs. Most OHA can regulate the gut microbiota by reducing the content of lipopolysaccharide, protecting the integrity of intestinal mucosal barrier, promoting the production of short-chain fatty acids and influencing the bile acid circulation, leading to the reduced inflammation, increased insulin sensitivity and pancreatic β cells function, and therefore, resulting in improved metabolic functions.

参考文献/References:

[1] Pryor R,Martinez-Martinez D,Quintaneiro L,et al.The role of the microbiome in drug response[J].Annu Rev Pharmacol Toxicol,2020,60:417-435.DOI: 10.1146/annurev-pharmtox-010919-023612.
[2] Gribble FM,Reimann F.Function and mechanisms of enteroendocrine cells and gut hormones in metabolism[J].Nat Rev Endocrinol,2019,15(4):226-237.DOI:10.1038/s41574-019-0168-8.
[3] Brønden A,Knop FK.Gluco-metabolic effects of pharmacotherapy-induced modulation of bile acid physiology[J].J Clin Endocrinol Metab,2020,105(1): dgz025.DOI:10.1210/clinem/dgz025.
[4] Kyriachenko Y,Falalyeyeva T,Korotkyi O,et al.Crosstalk between gut microbiota and antidiabetic drug action[J].World J Diabetes,2019,10(3):154-168.DOI:10.4239/wjd.v10.i3.154.
[5] Wu H,Esteve E,Tremaroli V,et al.Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes,contributing to the therapeutic effects of the drug[J].Nat Med,2017,23(7):850-858.DOI:10.1038/nm.4345.
[6] de la Cuesta-Zuluaga J,Mueller NT,Corrales-Agudelo V,et al.Metformin is associated with higher relative abundance of mucin-degrading akkermansia muciniphila and several short-chain fatty acid-producing microbiota in the gut[J].Diabetes Care,2017,40(1):54-62.DOI:10.2337/dc16-1324.
[7] Vallianou NG,Stratigou T,Tsagarakis S.Metformin and gut microbiota: their interactions and their impact on diabetes[J].Hormones(Athens),2019,18(2):141-144.DOI:10.1007/s42000-019-00093-w.
[8] Sanna S,van Zuydam NR,Mahajan A,et al.Causal relationships among the gut microbiome,short-chain fatty acids and metabolic diseases[J].Nat Genet, 2019,51(4):600-605.DOI:10.1038/s41588-019-0350-x.
[9] Sun L,Xie C,Wang G,et al.Gut microbiota and intestinal FXR mediate the clinical benefits of metformin[J].Nat Med,2018,24(12):1919-1929.DOI:10.1038/s41591-018-0222-4.
[10] Chávez-Talavera O,Tailleux A,Lefebvre P,et al.Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia, and nonalcoholic fatty liver disease[J].Gastroenterology,2017,152(7):1679-1694.e3.DOI:10.1053/j.gastro.2017.01.055.
[11] Zhang X,Fang Z,Zhang C,et al.Effects of acarbose on the gut microbiota of prediabetic patients:a randomized,double-blind,controlled crossover trial[J].Diabetes Ther,2017,8(2):293-307.DOI:10.1007/s13300-017-0226-y.
[12] Yan X,Feng B,Li P,et al.Microflora disturbance during progression of glucose intolerance and effect of sitagliptin:an animal study[J].J Diabetes Res,2016,2016:2093171.DOI:10.1155/2016/2093171.
[13] Olivares M,Schüppel V,Hassan AM,et al.The potential role of the dipeptidyl peptidase-4-like activity from the gut microbiota on the host health[J].Front Microbiol,2018,9:1900.DOI:10.3389/fmicb.2018.01900.
[14] Lee DM,Battson ML,Jarrell DK,et al.SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice[J].Cardiovasc Diabetol,2018,17(1):62.DOI:10.1186/s12933-018-0708-x.
[15] Madsen MSA,Grønlund RV,Eid J,et al.Characterization of local gut microbiome and intestinal transcriptome responses to rosiglitazone treatment in diabetic db/db mice[J].Biomed Pharmacother,2021,133:110966.DOI:10.1016/j.biopha.2020.110966.
[16] Li D,Feng Y,Tian M,et al.Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation[J].Microbiome,2021,9(1):83.DOI:10.1186/s40168-021-01028-7.
[17] 刘率男,刘泉,刘玉玲,等.桑枝总生物碱片研发历程回顾(二):现代药理学理念诠释中药的药效特点及药理作用机制[J].中国糖尿病杂志,2020,28(8):635-640.DOI:10.3969/j.issn.1006-6187.2020.08.015.
[18] Habtemariam S.Berberine pharmacology and the gut microbiota:a hidden therapeutic link[J].Pharmacol Res,2020,155:104722.DOI:10.1016/j.phrs.2020.104722.
[19] Forslund K,Hildebrand F,Nielsen T,et al.Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota[J].Nature,2015,528(7581):262-266.DOI:10.1038/nature15766.
[20] Bryrup T,Thomsen CW,Kern T,et al.Metformin-induced changes of the gut microbiota in healthy young men:results of a non-blinded, one-armed intervention study[J].Diabetologia,2019,62(6):1024-1035.DOI:10.1007/s00125-019-4848-7.

相似文献/References:

[1]曾静波,王姮.2型糖尿病与自身免疫反应[J].国际内分泌代谢杂志,2007,(04):259.
[2]朱素君,谢锦桃,刘军,等.二甲双胍:2型糖尿病治疗的基础药[J].国际内分泌代谢杂志,2007,(04):280.
[3]刘艳清 易秋艳 邵加庆.肠道菌群与肥胖和糖尿病的关系[J].国际内分泌代谢杂志,2015,(01):31.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.01.007]
 Liu Yanqing,Yi Qiuyan,Shao Jiaqing..Relationship between gut microbiota, obesity and diabetes[J].International Journal of Endocrinology and Metabolism,2015,(01):31.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.01.007]
[4]姚旻 赵爱源 张宏.肠道菌群与2型糖尿病[J].国际内分泌代谢杂志,2015,(01):35.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.01.008]
 Yao Min*,Zhao Aiyuan,Zhang Hong..Relationship between gut microbiota and type 2 diabetes[J].International Journal of Endocrinology and Metabolism,2015,(01):35.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.01.008]
[5]赵丽娟,徐宽枫,杨涛,等.SLC30A8和PTPRD基因多态性与南京地区中老年人群2型糖尿病的相关性研究[J].国际内分泌代谢杂志,2015,(03):145.[doi:10.3760/cma.j.issn.1673-4157.2015.03.001]
 Zhao Lijuan*,Xu Kuanfeng,Yang Tao,et al.Relationship between SLC30A8 and PTPRD gene polymorphisms and type 2 diabetes in middle aged and elderly people in Nanjing area[J].International Journal of Endocrinology and Metabolism,2015,(01):145.[doi:10.3760/cma.j.issn.1673-4157.2015.03.001]
[6]王洁,何媛,于珮.糖尿病肾病的相关危险因素分析[J].国际内分泌代谢杂志,2015,(03):153.[doi:10.3760/cma.j.issn.1673-4157.2015.03.003]
 Wang Jie*,He Yuan,Yu Pei..Risk factors of diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(01):153.[doi:10.3760/cma.j.issn.1673-4157.2015.03.003]
[7]刘帅,张萍,方毅,等.2型糖尿病合并无症状冠状动脉钙化的相关危险因素分析[J].国际内分泌代谢杂志,2015,(03):158.[doi:10.3760/cma.j.issn.1673-4157.2015.03.004]
 Liu Shuai*,Zhang Ping,Fang Yi,et al.Analysis of the risk factors related with asymptomatic coronary calcification for type 2 diabetic patients[J].International Journal of Endocrinology and Metabolism,2015,(01):158.[doi:10.3760/cma.j.issn.1673-4157.2015.03.004]
[8]徐庆海,马颖,李铁马.2型糖尿病患者高甘油三酯血症-腰围表型与甲状腺功能异常的关系[J].国际内分泌代谢杂志,2015,(04):222.[doi:10.3760/cma.j.issn.1673-4157.2015.04.002]
 Xu Qinghai,Ma Ying,Li Tiema..Association of hypertriglyceridaemic-waist phenotype with thyroid dysfunction in patients with type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2015,(01):222.[doi:10.3760/cma.j.issn.1673-4157.2015.04.002]
[9]潘道延,沈洁,朱筱,等.利格列汀对2型糖尿病大鼠代谢性内毒素血症的影响[J].国际内分泌代谢杂志,2015,(04):230.[doi:10.3760/cma.j.issn.1673-4157.2015.04.004]
 Pan Daoyan,Shen Jie,Zhu Xiao,et al.Effects of linagliptin on metabolic endotoxemia in type 2 diabetic rats[J].International Journal of Endocrinology and Metabolism,2015,(01):230.[doi:10.3760/cma.j.issn.1673-4157.2015.04.004]
[10]黄桥,白洁,杜洪泉.一种新的脂肪细胞因子——cartonectin[J].国际内分泌代谢杂志,2015,(04):265.[doi:10.3760/cma.j.issn.1673-4157.2015.04.014]
 Huang Qiao*,Bai Jie,Du Hongquan..A novel adipokine--cartonectin[J].International Journal of Endocrinology and Metabolism,2015,(01):265.[doi:10.3760/cma.j.issn.1673-4157.2015.04.014]

备注/Memo

备注/Memo:
通信作者:刘超,Email:liuchao@nfmcn.com
基金项目:国家自然科学基金(81800756); 江苏省六大人才高峰(WSN-035)
更新日期/Last Update: 2023-01-30