[1]蒋俊兰 刘尚全.血尿酸/肌酐比值与早期糖尿病肾脏病进展的关系[J].国际内分泌代谢杂志,2022,42(01):17-20,31.[doi:10.3760/cma.j.cn121383-20201024-10029]
　Jiang Junlan,Liu Shangquan..Relationship between serum uric acid to creatinine ratio and progression of early diabetic kidney disease[J].International Journal of Endocrinology and Metabolism,2022,42(01):17-20,31.[doi:10.3760/cma.j.cn121383-20201024-10029]
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血尿酸/肌酐比值与早期糖尿病肾脏病进展的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年01期
页码:
17-20,31
栏目:
论著
出版日期:
2022-01-20

文章信息/Info

Title:
Relationship between serum uric acid to creatinine ratio and progression of early diabetic kidney disease
作者:
蒋俊兰 刘尚全
安徽医科大学第三附属医院,合肥市第一人民医院内分泌科 230000
Author(s):
Jiang Junlan;  Liu Shangquan.
Department of Endocrinology, Third Affiliated Hospital of Anhui Medical University, Hefei First People's Hospital, Hefei 230000, China
关键词:
2型糖尿病;  尿酸/肌酐比值;  糖尿病肾脏病;  糖尿病慢性并发症
Keywords:
Type 2 diabetes mellitus;  Serum uric acid to creatinine ratio;  Diabetic kidney disease;  Diabetes chronic complications
DOI:
10.3760/cma.j.cn121383-20201024-10029
摘要:
目的 探讨尿酸/肌酐比值(UA/Cr)与早期糖尿病肾脏病患者肾功能进展的关系。方法 收集251例2型糖尿病(T2DM)患者的临床资料,计算UA/Cr值,并按三分位数法分为低UA/Cr组、中UA/Cr组、高UA/Cr组3组,评估UA/Cr水平对早期糖尿病肾脏病(DKD)患者肾功能进展的预测作用,肾功能快速进展为估算的肾小球滤过率持续下降超过每年5 ml·min-1·1.73 m-2。结果 随着UA/Cr组份的增加,年平均肾小球滤过率下降速度(eGFR/Y)及肾功能快速进展的发生率逐渐增高(P<0.001); 多重线性回归分析发现,UA/Cr与早期DKD患者的eGFR/Y独立正相关(B=1.448,P=0.010); 二元logistic回归分析发现,UA/Cr是DKD快速进展的危险因素(OR=5.553,P=0.035); 受试者工作特征曲线分析发现UA/Cr是预测DKD快速进展较好的指标。结论 UA/Cr是早期DKD患者eGFR/Y增加的危险因素,并且对于预测DKD快速进展具有重要的价值。
Abstract:
Objective To investigate the relationship between serum uric acid to serum creatinine ratio(UA/Cr)and progression of renal function in patients with early diabetic kidney disease(DKD).Methods The clinical data of 251 patients with T2DM were collected, and UA/Cr values were calculated. According to the trisection method, they were divided into three groups: low UA/Cr group, medium UA/Cr group and high UA/Cr group. The predictive value of UA/Cr level on renal function progress of patients with early diabetic nephropathy(DKD)were evaluated. The rapid progress of renal function was defined as eGFR decreased continuously by more than 5 ml·min-1·1.73 m-2 perannum.Results With the increase of UA/Cr component, the value of annual mean estimated glomerular filtration rate decline rate(eGFR/Y)and the incidence of rapid progress of renal function gradually increased(P<0.001). Multivariate linear regression analysis showed that UA/Cr was positively correlated with eGFR/Y of early DKD patients(B=1.448, P=0.010). Binary logistic regression analysis showed that UA/Cr was a risk factor for rapid development of DKD(OR=5.553, P=0.035). ROC curve showed that UA/Cr was a good index to predict the progress of DKD.Conclusion UA/Cr is a risk factor for eGFR/Y increase in patients with early DKD, and it has important value for predicting the rapid progress of DKD.

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备注/Memo

备注/Memo:
通信作者:刘尚全,Email:52100325@qq.com
更新日期/Last Update: 2022-01-20