[1]谢幸 陈树春 朱海娇 刘阳 王幸.蛙皮素样受体亚型-3与代谢综合征[J].国际内分泌代谢杂志,2018,38(03):176-178182.[doi:10.3760/cma.j.issn.1673-4157.2018.03.008]
 Xie Xing*,Chen Shuchun,Zhu Haijiao,et al.Bombesin receptor subtype-3 and metabolic syndrome[J].International Journal of Endocrinology and Metabolism,2018,38(03):176-178182.[doi:10.3760/cma.j.issn.1673-4157.2018.03.008]
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蛙皮素样受体亚型-3与代谢综合征()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年03期
页码:
176-178182
栏目:
综述
出版日期:
2018-05-20

文章信息/Info

Title:
Bombesin receptor subtype-3 and metabolic syndrome
作者:
谢幸 陈树春 朱海娇 刘阳 王幸
050017 石家庄,河北医科大学研究生学院(谢幸、王幸、朱海娇); 050051 石家庄,河北省人民医院内分泌一科(陈树春); 075000 张家口,河北北方学院研究生部(刘阳)
Author(s):
Xie Xing* Chen Shuchun Zhu Haijiao Liu Yang Wang Xing.*
Graduate School of Hebei Medical University, Shijiazhuang 050017, China
关键词:
蛙皮素样受体亚型-3 2型糖尿病 肥胖 代谢综合征
Keywords:
Bombesin receptor subtype-3 Type 2 diabetes mellitus Obesity Metabolic syndrome
DOI:
10.3760/cma.j.issn.1673-4157.2018.03.008
摘要:
蛙皮素样受体家族的蛙皮素样受体亚型-3(BRS-3)是一种G 蛋白耦联受体,主要存在于中枢神经系统和外周组织。研究发现,BRS-3基因敲除小鼠有糖代谢受损、基础代谢率降低、摄食与吸收增加、体重增加、胰岛素分泌增加、胰岛素抵抗、轻度高血压等一系列代谢性因素的变化。2型糖尿病合并肥胖人群的脂肪细胞、骨骼肌细胞中BRS-3 mRNA与蛋白质表达水平是减少的。研究发现,BRS-3激动剂有刺激胰岛素分泌、增加基础代谢率等作用,从而可能为治疗肥胖、2型糖尿病等代谢性疾病提供一个新思路。
Abstract:
The bombesin-like receptor subtype -3(BRS-3),a member of the bombesin-like receptor family, is a G-protein coupled receptor mainly found in the central nervous system and peripheral tissues. The study found that BRS-3 gene knockout mice had impaired glucose metabolism, decreased basal metabolic rate, increased food intake and absorption, weight gain, increased insulin secretion, insulin resistance, mild hypertension and a series of metabolic changes. In patients with type 2 diabetes mellitus and obesity, the expression of BRS-3 mRNA and protein in adipocytes, skeletal muscle cells have decreased. Studies found that BRS-3 agonists could stimulate insulin secretion, increase basal metabolic rate, which may provide a new insight for the treatment of metabolic disease such as obesity, type 2 diabetes.

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备注/Memo

备注/Memo:

通信作者:陈树春,Email:guang6701@sina.com Corresponding author: Chen Shuchun, Email: guang6701@sina.com
更新日期/Last Update: 2018-03-30