[1]周宇,柯甦捷,刘礼斌.血尿酸与糖尿病肾病[J].国际内分泌代谢杂志,2016,36(03):202-205.[doi:10.3760/cma.j.issn.1673-4157.2016.03.15]
 Zhou Yu,Ke Sujie,Liu Libin..Serum uric acid and diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2016,36(03):202-205.[doi:10.3760/cma.j.issn.1673-4157.2016.03.15]
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血尿酸与糖尿病肾病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年03期
页码:
202-205
栏目:
综述
出版日期:
2016-05-20

文章信息/Info

Title:
Serum uric acid and diabetic nephropathy
作者:
周宇柯甦捷刘礼斌
350001 福州,福建医科大学附属协和医院内分泌科
Author(s):
Zhou Yu Ke Sujie Liu Libin.
Department of Endocrinology, Union Hospital of Fujian Medical University, Fuzhou 350001, China
关键词:
尿酸 糖尿病肾病 高尿酸血症
Keywords:
Uric acid Diabetic nephropathy Hyperuricemia
DOI:
10.3760/cma.j.issn.1673-4157.2016.03.15
摘要:
血尿酸是嘌呤代谢的最终产物。近年来许多大型观察性队列研究已证实,血尿酸与糖尿病肾病的发生、发展密切相关。其主要机制包括内皮功能紊乱,肾素-血管紧张素-醛固酮系统过度激活及炎性瀑布反应等。别嘌呤醇、非布司他及某些调脂、降血压药物等干预糖尿病肾病高尿酸的药物,可以作为传统糖尿病肾病治疗的一种补充。
Abstract:
Serum uric acid is an end product from purine derivatives. Large observational cohort studies in recent years have demonstrated serum uric acid was correlated with the occurrence and development of diabetic nephropathy. The main mechanism mainly includes endothelial dysfunction, increased activity of renin-angiotensin-aldosterone system(RAAS)and induction of inflammatory cascades. Interventions of diabetic nephropathy along with high uric acid, such as allopurinol, febuxostat and some lipid-lowering and antihypentensive drugs, can complement traditional treatment of diabetic nephropathy.

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更新日期/Last Update: 2016-05-20