[1]赵建林,耿秀琴,李胜兰,等.2型糖尿病患者血戊糖素水平与椎体骨折的 研究[J].国际内分泌代谢杂志,2016,36(03):153-156.[doi:10.3760/cma.j.issn.1673-4157.2016.03.03]
　Zhao Jianlin*,Geng Xiuqin,Li Shenglan,et al.Relationship between serum pentosidine and vertebral fractures in type 2 diabetic patients[J].International Journal of Endocrinology and Metabolism,2016,36(03):153-156.[doi:10.3760/cma.j.issn.1673-4157.2016.03.03]
点击复制

2型糖尿病患者血戊糖素水平与椎体骨折的 研究()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年03期
页码:
153-156
栏目:
论著
出版日期:
2016-05-20

文章信息/Info

Title:
Relationship between serum pentosidine and vertebral fractures in type 2 diabetic patients
作者:
赵建林; 耿秀琴; 李胜兰; 郭献山; 王林栋; 周艳红; 随华; 陈玉凤; 孔亚坤 李江雁; 吴苏豫; 郝迎春; 郭振云; 赵海燕; 王英瑞; 李卫星
453000 河南省新乡市中心医院内分泌科(赵建林,耿秀琴,李胜兰,郭献山,王林栋,周艳红,随华, 陈玉凤,孔亚坤,李江雁,吴苏豫,郭振云,赵海燕,王英瑞),检验科(郝迎春),放射科(李卫星)
Author(s):
Zhao Jianlin*;  Geng Xiuqin;  Li Shenglan; Guo Xianshan;  Wang Lindong;  Zhou Yanhong; Sui Hua; Chen Yufeng; Kong Yakun; Li Jiangyan; Wu Suyu;  Hao Yingchun; Guo Zhenyun; Zhao Haiyan; Wang Yingrui; Li Weixing.
*Department of Endocrinology,Xinxiang Central Hospital, Xinxiang 453000,China
关键词:
2型糖尿病;  戊糖素;  骨密度;  椎体骨折
Keywords:
Type 2 diabetes mellitus;  Pentosidine;  Bone mineral density;  Vertebral fractures
DOI:
10.3760/cma.j.issn.1673-4157.2016.03.03
摘要:
目的 探讨2型糖尿病患者骨密度的变化,研究血戊糖素与2型糖尿病患者椎体骨折的相关性。方法 选取100例2型糖尿病患者作为糖尿病组,另选取70名非糖尿病者作为对照组,受试者年龄均大于60岁。所有受试者均行胸腰椎X线检查以确定椎体骨折,同时检测受试者的腰椎骨密度,抽取空腹静脉血查戊糖素及骨代谢指标。判断两组腰椎骨密度、椎体骨折发生率的差异,同时分析血戊糖素水平与椎体骨折的相关性。结果 两组的年龄、体重指数、骨代谢指标、骨密度水平差异均无统计学意义(P均>0.05)。糖尿病组戊糖素水平及椎体骨折的发生率均较对照组明显升高(t=5.764, χ2=6.286,P均<0.05)。相关性分析提示,椎体骨折与戊糖素水平呈正相关(r=0.236,P=0.018)。回归分析显示,椎体骨折与戊糖素水平独立相关(OR=1.008,95%CI: 1.001～1.015, P=0.032)。结论 血戊糖素可能作为老年2型糖尿病患者椎体骨折风险评估的指标。
Abstract:
Objective To investigate the changes of bone mineral density(BMD)and the relationship between serum pentosidine and vertebral fractures in patients with type 2 diabetes mellitus(T2DM). Methods A total of 100 cases of patients with T2DM were enrolled as diabetes group and 70 cases of nondiabetic persons were enrolled as control group. They were all older than 60 years. Serum pentosidine, bone turnover markers and BMD of lumbar spine were determined. Thoracic and lumbar spinal X rays were taken to determined the vertebral fractures.Differences of BMD of lumbar spine and vertebral fracture rates between two groups were compared, and correlation of serum pentosidine levels and vertebral fractures were analyzed. Results Level of pentosidine and incidence of vertebral fractures were higher in diabetes group(t=5.764, χ2=6.286, all P<0.05), although there were no difference between the two groups in age, body mass index, bone turnover markers and BMD(all P>0.05). Correlation analysis showed level of pentosidine was positively correlated with vertebral fracture(r=0.236, P=0.018). Logistic regression revealed pentosidine was an independent determinant of vertebra fractures(OR=1.008,95%CI: 1.001-1.015, P=0.032). Conclusion Serum pentosidine may be used as an index for monitoring the risk of vertebral fractures in elderly diabetic patients.

参考文献/References:

[1] Sanguineti R, Puddu A, Mach F,et al. Advanced glycation end products play adverse proinflammatory activities in osteoporosis[J]. Mediators Inflamm, 2014,2014: 975872.DOI:10.1155/2014/975872.
[2] Hein G, Weiss C, Lehmann G, et al. Advanced glycation end product modification of bone proteins and bone remodelling: hypothesis and preliminary immunohistochemical findings[J]. Ann Rheum Dis, 2006,65(1): 101-104.
[3] 刘忠厚.骨质疏松学[M].北京科学出版社,1998:460-471.
[4] de Liefde II, van der Klift M, de Laet CE,et al. Bone mineral density and fracture risk in type-2 diabetes mellitus: the Rotterdam Study[J]. Osteoporos Int,2005,16(12):1713-1720.
[5] Peter J, Juraj P. Osteoporosis, fractures, and diabetes[J]. Int J Endocrinol,2014,2014:820615.DOI:10.1155/2014/820615.
[6] Ji JD, Woo JH, Choi SJ, et al. Advanced glycation end-products(AGEs): a novel therapeutic target for osteoporosis in patients with rheumatoid arthritis[J]. Med Hypotheses, 2009,73(2):201-202. DOI:10.1016/j.mehy.2009.02.020.
[7] Sanguineti R, Storace D, Monacelli F, et al. Pentosidine effects on human osteoblasts in vitro[J]. Ann N Y Acad Sci, 2008,1126:166-172.DOI:10.1196/annals.1443.044.
[8] Odetti P, Rossi S, Monacelli F,et al. Advanced glycation end products and bone loss during aging[J]. Ann N Y Acad Sci, 2005,1043:710-717.
[9] Yamagishi SI, Maeda S, Matsui T, et al. Role of advanced glycation end products(AGEs)and oxidative stress in vascular complications in diabetes[J]. Biochim Biophys Acta, 2012,1820(5): 663-671. DOI:10.1016/j.bbagen.2011.03.014.
[10] Yamamoto M, Yamaguchi T, Yamauchi M, et al. Serum pentosidine levels are positively associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes[J]. J Clin Endocrinol Metab,2008,93(3):1013-1019.

相似文献/References:

[1]曾静波,王姮.2型糖尿病与自身免疫反应[J].国际内分泌代谢杂志,2007,(04):259.
[2]朱素君,谢锦桃,刘军,等.二甲双胍：2型糖尿病治疗的基础药[J].国际内分泌代谢杂志,2007,(04):280.
[3]刘艳清 易秋艳 邵加庆.肠道菌群与肥胖和糖尿病的关系[J].国际内分泌代谢杂志,2015,(01):31.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.007]
　Liu Yanqing,Yi Qiuyan,Shao Jiaqing..Relationship between gut microbiota, obesity and diabetes[J].International Journal of Endocrinology and Metabolism,2015,(03):31.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.007]
[4]姚旻 赵爱源 张宏.肠道菌群与2型糖尿病[J].国际内分泌代谢杂志,2015,(01):35.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.008]
　Yao Min*,Zhao Aiyuan,Zhang Hong..Relationship between gut microbiota and type 2 diabetes[J].International Journal of Endocrinology and Metabolism,2015,(03):35.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.008]
[5]赵丽娟,徐宽枫,杨涛,等.SLC30A8和PTPRD基因多态性与南京地区中老年人群2型糖尿病的相关性研究[J].国际内分泌代谢杂志,2015,(03):145.[doi:10.3760/cma.j.issn.1673-4157.2015.03.001]
　Zhao Lijuan*,Xu Kuanfeng,Yang Tao,et al.Relationship between SLC30A8 and PTPRD gene polymorphisms and type 2 diabetes in middle aged and elderly people in Nanjing area[J].International Journal of Endocrinology and Metabolism,2015,(03):145.[doi:10.3760/cma.j.issn.1673-4157.2015.03.001]
[6]王洁,何媛,于珮.糖尿病肾病的相关危险因素分析[J].国际内分泌代谢杂志,2015,(03):153.[doi:10.3760/cma.j.issn.1673-4157.2015.03.003]
　Wang Jie*,He Yuan,Yu Pei..Risk factors of diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(03):153.[doi:10.3760/cma.j.issn.1673-4157.2015.03.003]
[7]刘帅,张萍,方毅,等.2型糖尿病合并无症状冠状动脉钙化的相关危险因素分析[J].国际内分泌代谢杂志,2015,(03):158.[doi:10.3760/cma.j.issn.1673-4157.2015.03.004]
　Liu Shuai*,Zhang Ping,Fang Yi,et al.Analysis of the risk factors related with asymptomatic coronary calcification for type 2 diabetic patients[J].International Journal of Endocrinology and Metabolism,2015,(03):158.[doi:10.3760/cma.j.issn.1673-4157.2015.03.004]
[8]徐庆海,马颖,李铁马.2型糖尿病患者高甘油三酯血症-腰围表型与甲状腺功能异常的关系[J].国际内分泌代谢杂志,2015,(04):222.[doi:10.3760/cma.j.issn.1673-4157.2015.04.002]
　Xu Qinghai,Ma Ying,Li Tiema..Association of hypertriglyceridaemic-waist phenotype with thyroid dysfunction in patients with type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2015,(03):222.[doi:10.3760/cma.j.issn.1673-4157.2015.04.002]
[9]潘道延,沈洁,朱筱,等.利格列汀对2型糖尿病大鼠代谢性内毒素血症的影响[J].国际内分泌代谢杂志,2015,(04):230.[doi:10.3760/cma.j.issn.1673-4157.2015.04.004]
　Pan Daoyan,Shen Jie,Zhu Xiao,et al.Effects of linagliptin on metabolic endotoxemia in type 2 diabetic rats[J].International Journal of Endocrinology and Metabolism,2015,(03):230.[doi:10.3760/cma.j.issn.1673-4157.2015.04.004]
[10]黄桥,白洁,杜洪泉.一种新的脂肪细胞因子——cartonectin[J].国际内分泌代谢杂志,2015,(04):265.[doi:10.3760/cma.j.issn.1673-4157.2015.04.014]
　Huang Qiao*,Bai Jie,Du Hongquan..A novel adipokine--cartonectin[J].International Journal of Endocrinology and Metabolism,2015,(03):265.[doi:10.3760/cma.j.issn.1673-4157.2015.04.014]

更新日期/Last Update: 2016-05-20