[1]郑仁东,曹琳,刘克冕,等.超重或肥胖的男性2型糖尿病患者 性激素水平的研究[J].国际内分泌代谢杂志,2015,(02):84-87.[doi:10.3760/cma.j.issn.1673-4157.2015.02.004]
　Zheng Rendong,Cao Lin,Liu Kemian,et al.Study on sex hormone levels in overweight or obese type 2 diabetic male patients[J].International Journal of Endocrinology and Metabolism,2015,(02):84-87.[doi:10.3760/cma.j.issn.1673-4157.2015.02.004]
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超重或肥胖的男性2型糖尿病患者 性激素水平的研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年02
页码:
84-87
栏目:
论著
出版日期:
2015-03-20

文章信息/Info

Title:
Study on sex hormone levels in overweight or obese type 2 diabetic male patients
作者:
郑仁东; 曹琳; 刘克冕; 褚晓秋; 曹雯; 孙洪平; 刘超
210028　南京，中国中医科学院江苏分院，南京中医药大学附属中西医结合医院内分泌代谢病院区
Author(s):
Zheng Rendong; Cao Lin; Liu Kemian; Chu Xiaoqiu; Cao Wen; Sun Hongping; Liu Chao.
Endocrine and Diabetes Center，Jiangsu Province Hospital on Integration of Chinese and Western Medicine，Nanjing University of Traditional Chinese Medicine，Jiangsu Branch of China Academy of Chinese Medical Science，Nanjing 210028， China Corresponding author：Liu Chao，Email：liuchao@jsatcm.com
关键词:
尿病; 肥胖; 性腺功能减退症; 男性; 睾酮
Keywords:
Diabetes mellitus; Obesity; Hypogonadism; Male; Testosterone
DOI:
10.3760/cma.j.issn.1673-4157.2015.02.004
摘要:
目的　观察超重或肥胖的男性2型糖尿病患者性激素水平及胰岛素抵抗、糖脂代谢的变化。方法　选择男性2型糖尿病患者112例，根据体重指数分为体重正常组（50例）和超重或肥胖组（62例）。所有患者测定血糖、血脂、胰岛素及性激素水平，包括睾酮、性激素结合球蛋白（SHBG）、孕激素、催乳素、黄体生成素、卵泡刺激素、雌二醇、脱氢表雄酮，并计算得出游离睾酮、生物活性睾酮。比较两组性激素水平、糖脂代谢及胰岛素抵抗相关指标的差异。结果　与体重正常组相比，超重或肥胖组空腹血糖、HbA1c、尿酸、空腹胰岛素和餐后胰岛素水平显著升高（t =-4.58~-2.35，P均＜0.05）；总睾酮、SHBG水平显著降低（t =2.17，2.06，P均＜0.05）。Pearson相关性分析发现，体重指数、腰围与总睾酮（r =-0.40，-0.41，P均＜0.01）、SHBG（r =-0.33，-0.42，P均＜0.01）呈显著负相关。总胆固醇和甘油三酯与总睾酮（r =-0.28，-0.24，P 均=0.01）、SHBG（r =-0.27，-0.37，P均≤0.01）呈负相关；空腹胰岛素、餐后胰岛素、稳态模型评估-胰岛素抵抗指数（HOMA-IR）与总睾酮（r =-0.30～-0.21，P均 =0.01）、SHBG水平（r =-0.29～-0.20，P均≤0.05）呈负相关。结论　超重或肥胖的男性2型糖尿病患者常存在性腺功能减退症，并与胰岛素抵抗和脂代谢异常密切相关。
Abstract:
Objective　To investigate the changes of sex hormone levels，insulin resistance，glucose and lipid metabolism in overweight or obese type 2 diabetic male patients. Methods　A total of 112 type 2 diabetic male patients were enrolled and divided into normal weight group（n=50） and overweight or obese group（n=62） according to body mass index. Blood glucose，blood lipids， insulin，and sex hormones including testosterone，sex hormone binding globulin（SHBG），pregnendione， prolactin， luteinizing hormone，follicle-stimulating hormone，estradiol，dehydroepiandrosterone were measured，and free testosterone and bioavailable testosterone were calculated. The correlations between sex hormone levels and glycolipid metabolism，insulin resistance related markers were analyzed. Results　Compared with normal weight group，fasting blood glucose，HbA1c，uric acid，fasting insulin，postprandial insulin were significantly increased in overweight or obese group （t = -4.58--2.35， all P＜0.05）； total testosterone and SHBG levels were significantly decreased （t =2.17，2.06，all P＜0.05） in overweight or obese group. Pearson correlation analysis found that body mass index，waist circumference were negatively correlated with total testosterone （r =-0.40，-0.41，all P＜0.01） and SHBG （r =-0.33，-0.42，all P＜0.01）.Total cholesterol and triglycerides were negatively correlated with total testosterone（r =-0.28，-0.24，all P =0.01） and SHBG（r =-0.27，-0.37，all P≤0.01）. Fasting insulin，postprandial insulin and homeostasis model assessment-insulin resistance were negatively correlated with total testosterone （r =-0.30--0.21，all P =0.01） and SHBG（r =-0.29--0.20，all P≤0.05）. Conclusions　Hypogonadism is common in overweight or obese type 2 diabetic male patients，and is associated with insulin resistance and dyslipidemia.

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备注/Memo

备注/Memo:
通信作者：刘超，Email： liuchao@jsatcm.com
更新日期/Last Update: 2015-03-20