参考文献/References:
[1] Huang TD,Behary J,Zekry A.Non-alcoholic fatty liver disease:a review of epidemiology,risk factors,diagnosis and management[J].Intern Med J,2020,50(9):1038-1047.DOI:10.1111/imj.14709.
[2] Buzzetti E,Pinzani M,Tsochatzis EA.The multiple-hit pathogenesis of non-alcoholic fatty liver disease(NAFLD)[J].Metabolism,2016,65(8):1038-1048.DOI:10.1016/j.metabol.2015.12.012.
[3] Wang X,Rao H,Zhao J,et al.STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease[J].Lab Invest,2020,100(4):542-552.DOI:10.1038/s41374-019-0342-6.
[4] Rada P,González-Rodríguez Á,García-Monzn C,et al.Understanding lipotoxicity in NAFLD pathogenesis:is CD36 a key driver?[J].Cell Death Dis,2020,11(9):802.DOI:10.1038/s41419-020-03003-w.
[5] Luo Z,Ji Y,Zhang D,et al.Microbial DNA enrichment promotes liver steatosis and fibrosis in the course of non-alcoholic steatohepatitis[J].Acta Physiol(Oxf),2022,235(3):e13827.DOI:10.1111/apha.13827.
[6] Sun L,Wu J,Du F,et al.Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type Ⅰ interferon pathway[J].Science,2013,339(6121):786-791.DOI:10.1126/science.1232458.
[7] Wu J,Sun L,Chen X,et al.Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA[J].Science,2013,339(6121):826-830.DOI:10.1126/science.1229963.
[8] Zhang C,Shang G,Gui X,et al.Structural basis of STING binding with and phosphorylation by TBK1[J].Nature,2019,567(7748):394-398.DOI:10.1038/s41586-019-1000-2.
[9] Balka KR,Louis C,Saunders TL,et al.TBK1 and IKKε act redundantly to mediate STING-induced NF-κB responses in myeloid cells[J].Cell Rep,2020,31(1):107492.DOI:10.1016/j.celrep.2020.03.056.
[10] Dunphy G,Flannery SM,Almine JF,et al.Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-κB signaling after nuclear DNA damage[J].Mol Cell,2018,71(5):745-760.e5.DOI:10.1016/j.molcel.2018.07.034.
[11] Motwani M,Pesiridis S,Fitzgerald KA.DNA sensing by the cGAS-STING pathway in health and disease[J].Nat Rev Genet,2019,20(11):657-674.DOI:10.1038/s41576-019-0151-1.
[12] Yu Y,Liu Y,An W,et al.STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis[J].J Clin Invest,2019,129(2):546-555.DOI:10.1172/JCI121842.
[13] Luo Z,Ji Y,Gao H,et al.CRIg+ macrophages prevent gut microbial DNA-containing extracellular vesicle-induced tissue inflammation and insulin resistance[J].Gastroenterology,2021,160(3):863-874.DOI:10.1053/j.gastro.2020.10.042.
[14] 马林强.STING促进巨噬细胞介导的非酒精性脂肪肝病的进展[D].重庆:重庆医科大学,2019.
[15] Mao Y,Luo W,Zhang L,et al.STING-IRF3 triggers endothelial inflammation in response to free fatty acid-induced mitochondrial damage in diet-induced obesity[J].Arterioscler Thromb Vasc Biol,2017,37(5):920-929. DOI:10.1161/ATVBAHA.117.309017.
[16] Miyao M,Kotani H,Ishida T,et al.Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression[J].Lab Invest,2015,95(10):1130-1144.DOI:10.1038/labinvest.2015.95.
[17] Cho CS,Park HW,Ho A,et al.Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation[J].Hepatology,2018,68(4):1331-1346.DOI:10.1002/hep.29742.
[18] Liu K,Qiu D,Liang X,et al.Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy[J].Autophagy,2022,18(4):860-876.DOI:10.1080/15548627.2021.1961072.
[19] Akhmetova K,Balasov M,Chesnokov I.Drosophila STING protein has a role in lipid metabolism[J].Elife,2021,10:e67358.DOI:10.7554/eLife.67358.
[20] Qiao JT,Cui C,Qing L,et al.Activation of the STING-IRF3 pathway promotes hepatocyte inflammation,apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease[J].Metabolism,2018,81:13-24.DOI:10.1016/j.metabol.2017.09.010.
[21] Cao L,Xu E,Zheng R,et al.Traditional Chinese medicine Lingguizhugan decoction ameliorate HFD-induced hepatic-lipid deposition in mice by inhibiting STING-mediated inflammation in macrophages[J].Chin Med,2022,17(1):7.DOI:10.1186/s13020-021-00559-3.
[22] Li YN,Su Y.Remdesivir attenuates high fat diet(HFD)-induced NAFLD by regulating hepatocyte dyslipidemia and inflammation via the suppression of STING[J].Biochem Biophys Res Commun,2020,526(2):381-388.DOI:10.1016/j.bbrc.2020.03.034.
[23] Armandi A,Rosso C,Caviglia GP,et al.Insulin resistance across the spectrum of nonalcoholic fatty liver disease[J].Metabolites,2021,11(3):155.DOI:10.3390/metabo11030155.
[24] Hu H,Zhao R,He Q,et al.cGAS-STING mediates cytoplasmic mitochondrial-DNA-induced inflammatory signal transduction during accelerated senescence of pancreatic β-cells induced by metabolic stress[J].FASEB J,2022,36(5):e22266.DOI:10.1096/fj.202101988R.
[25] Hu HQ,Qiao JT,Liu FQ,et al.The STING-IRF3 pathway is involved in lipotoxic injury of pancreatic β cells in type 2 diabetes[J].Mol Cell Endocrinol,2020,518:110890.DOI:10.1016/j.mce.2020.110890.
[26] Iracheta-Vellve A,Petrasek J,Gyongyosi B,et al.Endoplasmic reticulum stress-induced hepatocellular death pathways mediate liver injury and fibrosis via stimulator of interferon genes[J].J Biol Chem,2016,291(52):26794-26805.DOI:10.1074/jbc.M116.736991.
[27] Thomsen MK,Skouboe MK,Boularan C,et al.The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma[J].Oncogene,2020,39(8):1652-1664.DOI:10.1038/s41388-019-1108-8.
[28] Zhang Y,Zhai Q,Feng X,et al.Cancer cell-intrinsic STING is associated with CD8+T-cell infiltration and might serve as a potential immunotherapeutic target in hepatocellular carcinoma[J].Clin Transl Oncol,2021,23(7):1314-1324.DOI:10.1007/s12094-020-02519-z.
[29] 韦志行.cGAS-STING激动剂增强巨噬细胞对肝癌细胞吞噬作用的研究[D].济南:山东大学,2021.DOI:10.27272/d.cnki.gshdu.2021.003843.
[30] Dou Z,Ghosh K,Vizioli MG,et al.Cytoplasmic chromatin triggers inflammation in senescence and cancer[J].Nature,2017,550(7676):402-406.DOI:10.1038/nature24050.
[31] Garcia-Diaz A,Shin DS,Moreno BH,et al.Interferon receptor signaling pathways regulating PD-L1 and PD-L2 expression[J].Cell Rep,2017,19(6):1189-1201.DOI:10.1016/j.celrep.2017.04.031.
[32] Wu J,Dobbs N,Yang K,et al.Interferon-independent activities of mammalian STING mediate antiviral response and tumor immune evasion[J].Immunity,2020,53(1):115-126.e5.DOI:10.1016/j.immuni.2020.06.009.
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