[1]罗德钦,李智明,林慧,等.血清pannexin-1与2型糖尿病周围神经 病变的相关性研究[J].国际内分泌代谢杂志,2022,42(06):520-524.[doi:10.3760/cma.j.cn121383-20201214-12040]
　Luo Deqin,Li Zhiming,Lin Hui,et al.Serum pannexin-1 level and its clinical significance in patients with type 2 diabetes mellitus and diabetic peripheral neuropathy[J].International Journal of Endocrinology and Metabolism,2022,42(06):520-524.[doi:10.3760/cma.j.cn121383-20201214-12040]
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血清pannexin-1与2型糖尿病周围神经 病变的相关性研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年06期
页码:
520-524
栏目:
论著
出版日期:
2022-11-20

文章信息/Info

Title:
Serum pannexin-1 level and its clinical significance in patients with type 2 diabetes mellitus and diabetic peripheral neuropathy
作者:
罗德钦; 李智明; 林慧; 张菊云; 华炳红
中南大学湘雅医学院附属海口医院 内分泌科 570208
Author(s):
Luo Deqin;  Li Zhiming;  Lin Hui;  Zhang Juyun;  Hua Binghong.
Department of Endocrinology, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou 570208, China
关键词:
2型糖尿病;  糖尿病周围神经病变;  缝隙连接蛋白-1
Keywords:
Type 2 diabetes mellitus;  Diabetes peripheral neuropathy;  Pannexin-1
DOI:
10.3760/cma.j.cn121383-20201214-12040
摘要:
目的 探讨2型糖尿病(T2DM)合并糖尿病周围神经病变(DPN)患者血清缝隙连接蛋白(pannexin)-1水平及临床意义。方法 选取2017年6月至2020年6月中南大学湘雅医学院附属海口医院收治的350例T2DM患者纳入研究,根据患者是否合并DPN,将其分为T2DM合并DPN组和T2DM非DPN组,分别为163例和187例,其中,T2DM合并DPN组又分为痛性病变组(PDPN组)和非痛性病变组(NPDPN组),分别71例和92例。另选取体检健康者50名作为对照组。分别采集3组血液标本,检测并比较3组血清pannexin-1水平及相关实验室指标。结果 3组血清pannexin-1水平比较差异显著(P均<0.05); T2DM合并DPN组患者血清pannexin-1水平显著高于T2DM非DPN组和对照组(P均<0.05); T2DM非DPN组患者血清pannexin-1水平显著高于对照组(P<0.05); PDPN组患者血清pannexin-1水平显著高于NPDPN组(P<0.001); 与对照组比较,T2DM合并DPN组和T2DM非DPN组甘油三酯(TG)、糖化血红蛋白A1c(HbA1c)、空腹血糖(FPG)、空腹胰岛素(Fins)及稳态模型评估-胰岛素抵抗指数(HOMA-IR)较高,而感觉神经的神经传导速度(NCV)、运动神经NCV及高密度脂蛋白-胆固醇(HDL-C)较低(P均<0.05); 与T2DM非DPN组比较,T2DM合并DPN组HbA1c和FPG较高,而运动神经NCV较低(P均<0.05); 由Spearman分析结果可知,血清pannexin-1与HbA1c、FPG呈正相关(P均<0.05); 血清pannexin-1与感觉神经NCV、运动神经NCV呈负相关(P均<0.05); logistic分析结果显示,血清pannexin-1、HbA1c、FPG、运动神经NCV是影响T2DM并发DPN的独立危险因素(P均<0.05)。结论 Pannexin-1在T2DM合并DPN患者血清中呈高表达,且其表达水平与DPN患者疼痛程度有关,其有助于T2DM并发DPN的临床诊断。
Abstract:
Objective To explore the level of serum connexin(pannexin)-1 and its clinical significance in patients with type 2 diabetes mellitus(T2DM)and diabetic peripheral neuropathy.Methods From June 2017 to June 2020, 350 cases of T2DM patients admitted toHaikou Affiliated Hospital of Central South University Xiangya School of Medicinewere selected for inclusion in the study. According to whether patients have DPN, they are divided into T2DM combined DPN group(163 cases)and T2DM non-DPN group(187 cases). Among them, the T2DM combined DPN group was further divided into a painful lesion group(PDPN group, 71 cases)and a non-painful lesion group(NPDPN group, 92 cases). In addition, 50 healthy patients were selected as the control group. The levels of serum pannexin-1 and related laboratory indicators in the three groups were compared.Results The serum pannexin-1 levels of the three groups were significantly different(all P<0.05). The serum pannexin-1 level of patients in the T2DM combined with DPN group was significantly higher than that of the T2DM non-DPN group and the control group(all P<0.05). The serum pannexin-1 level of the T2DM non-DPN group was significantly higher than that of the control group(P<0.05). The level of serum pannexin-1 in PDPN group was significantly higher than that in NPDPN group(P<0.001). Compared with the control group, the T2DM combined with DPN group and the T2DM non-DPN group had higher triglyceride(TG), glycated hemoglobin(HbA1c), fasting blood glucose(FPG), fasting insulin(Fins)and insulin resistance index(HOMA-IR), while lower sensory nerve conduction velocity(NCV), motor nerve conduction velocity(NCV)and high-density lipoprotein(HDL-C)(all P<0.05). Compared with the T2DM non-DPN group, the T2DM combined DPN group has higher HbA1c and FPG, while motor nerve NCV was lower(all P<0.05). According to the results of Spearman analysis, serum pannexin-1 was positively correlated with HbA1c and FPG(all P<0.05). Serum pannexin-1 was negatively correlated with sensory nerve NCV and motor nerve NCV(all P<0.05). Logistic analysis showed that serum pannexin-1, HbA1c, FPG, motor nerve NCV were independent risk factors that affect T2DM with DPN(all P<0.05).Conclusion Pannexin-1 is highly expressed in the serum of patients with T2DM and DPN, and its expression level is related to the degree of pain in DPN patients, which is helpful the clinical diagnosis of T2DM and DPN.

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通信作者:罗德钦, Email:luo006deqin@163.com
更新日期/Last Update: 2022-12-01