[1]张明亮,李爱玲,王玉涛.2型糖尿病患者发生小腿肌间静脉血栓的危险因素分析[J].国际内分泌代谢杂志,2021,41(05):450-454.[doi:10.3760/cma.j.cn121383-20201210-12033]
　Zhang Mingliang,Li Ailing,Wang Yutao..Analysis of risk factors of calf muscular venous thrombosis in patients with type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2021,41(05):450-454.[doi:10.3760/cma.j.cn121383-20201210-12033]
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2型糖尿病患者发生小腿肌间静脉血栓的危险因素分析()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年05期
页码:
450-454
栏目:
论著
出版日期:
2021-09-30

文章信息/Info

Title:
Analysis of risk factors of calf muscular venous thrombosis in patients with type 2 diabetes mellitus
作者:
张明亮1; 李爱玲2; 王玉涛3
1济南市中医医院 250012; 2滕州市中医医院内分泌科,枣庄 277599; 3济南市中医医院周围血管病科 250012
Author(s):
Zhang Mingliang1;  Li Ailing2;  Wang Yutao1.
1Jinan Municipal Hospital of Traditional Chinese Medicine, Jinan 250012, China; 2Department of Endocrinology, Tengzhou Traditional Chinese Medicine Hospital, Zaozhuang 277599, China; 3Department of Peripheral Vascular Disease, Jinan Municipal Hospital of Traditional Chinese Medicine, Jinan 250012, China
关键词:
小腿肌间静脉血栓;  2型糖尿病;  危险因素
Keywords:
Calf muscular venous thrombosis;  Type 2 diabetes mellitus;  Risk factors
DOI:
10.3760/cma.j.cn121383-20201210-12033
摘要:
目的 探讨2型糖尿病患者发生小腿肌间静脉血栓的危险因素。方法 回顾性分析2012年1月至2021年5月于济南市中医医院内分泌科及滕州市中医医院内分泌科住院治疗的174例2型糖尿病患者的临床资料,根据是否发生小腿肌间静脉血栓分为血栓组与对照组,对比分析两组患者的性别、年龄、体重指数、糖尿病病程等临床资料,进行单因素分析,组间比较有显著差异的单因素,代入二元logistic回归分析进行独立危险因素检验。结果 两组患者性别、糖尿病周围血管病变、糖化血红蛋白水平、甘油三酯水平、总胆固醇水平、超敏C反应蛋白水平差异均有统计学意义(P均<0.05)。结论 性别、糖尿病周围血管病变、甘油三酯水平、总胆固醇水平、超敏C反应蛋白水平是2型糖尿病患者发生小腿肌间静脉血栓的独立危险因素。
Abstract:
Objective To investigate the risk factors of calf muscular venous thrombosis in patients with type 2 diabetes mellitus.Methods The clinical data of 174 patients hospitalized in the Department of Endocrinology of Jinan Municiple Hospital of Traditional Chinese Medicine and the Department of Endocrinology of Tengzhou Traditional Chinese Medicine Hospital from January 2012 to May 2021 were retrospectively analyzed. The patients were divided into thrombosis group and control group according to the occurrence of calf muscular venous thrombosis, and the clinical data of the two groups, such as age, body mass index, duration of diabetes, were compared and analyzed in a single-factor analysis. The single factors with significant differences between two groups were substituted into binary logistic regression analysis for independent risk factor test.Results Gender, number of patients with diabetic peripheral vasculopathy, level of glycosylated hemoglobin, triglyceride, total cholesterol and high sensitivity C-reactive protein level between two groups were statistically different(all P<0.05).Conclusion Diabetic peripheral vasculopathy and high sensitivity C-reactive protein level are the independent risk factors of calf muscular venous thrombosis in patients with type 2 diabetes mellitus.

参考文献/References:

[1] Xia ZN,Xiao K,Zhu W,et al.Risk assessment and management of preoperative venous thromboembolism following femoral neck fracture[J].J Orthop Surg Res,2018,13(1):291.DOI:10.1186/s13018-018-0998-4.
[2] Galanaud JP,Sevestre MA,Genty C,et al.Comparison of the clinical history of symptomatic isolated muscular calf vein thrombosis versus deep calf vein thrombosis[J].J Vasc Surg,2010,52(4):932-938,938.e1-2.DOI:10.1016/j.jvs.2010.05.019.
[3] Gillet JL,Perrin MR,Allaert FA.Short-term and mid-term outcome of isolated symptomatic muscular calf vein thrombosis[J].J Vasc Surg,2007,46(3):513-519; discussion 519.DOI:10.1016/j.jvs.2007.04.040.
[4] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志,2018,38(4):292-344.DOI:10.19538/j.nk2018040108.
[5] Henry JC,Satiani B.Calf muscle venous thrombosis:a review of the clinical implications and therapy[J].Vasc Endovascular Surg,2014,48(5-6):396-401.DOI:10.1177/1538574414541704.
[6] Uhl JF,Gillot C.Anatomy of the veno-muscular pumps of the lower limb[J].Phlebology,2015,30(3):180-193.DOI:10.1177/0268355513517686.
[7] Su H,Liu H,Liu J,et al.Elderly patients with intertrochanteric fractures after intramedullary fixation:analysis of risk factors for calf muscular vein thrombosis[J].Orthopade,2018,47(4):341-346.DOI:10.1007/s00132-018-3552-5.
[8] 凌端强,杨涛,郝斌.小腿肌间静脉丛血栓形成认识及诊治进展[J].血管与腔内血管外科杂志,2015,1(Z1):185-189.DOI:10.19418/j.cnki.issn2096-0646.2015.z1.025.
[9] 张宇,王红霞,赵君.高频彩色多普勒超声对小腿肌间静脉丛血栓的应用价值[J].中国医疗设备,2017,32(5):84-86.DOI:10.3969/j.issn.1674-1633.2017.05.021.
[10] Kakkos SK,Gohel M,Baekgaard N,et al.Editor's Choice -European Society for Vascular Surgery(ESVS)2021 Clinical Practice Guidelines on the Management of Venous Thrombosis[J].Eur J Vasc Endovasc Surg,2021,61(1):9-82.DOI:10.1016/j.ejvs.2020.09.023.
[11] Abou-Ismail MY,Citla Sridhar D,Nayak L.Estrogen and thrombosis:a bench to bedside review[J].Thromb Res,2020,192:40-51.DOI:10.1016/j.thromres.2020.05.008.
[12] Galanaud JP,Sevestre MA,Pernod G,et al.Epidemiology and 3-year outcomes of combined oral contraceptive-associated distal deep vein thrombosis[J].Res Pract Thromb Haemost,2020,4(7):1216-1223.DOI:10.1002/rth2.12409.
[13] Dupuis M,Severin S,Noirrit-Esclassan E,et al.Effects of estrogens on platelets and megakaryocytes[J].Int J Mol Sci,2019,20(12):3111.DOI:10.3390/ijms20123111.
[14] Alotaibi HK,Abo El-Fetoh NM,MenwerAlanazi A,et al.Deep venous thrombosis among diabetic patients in King Abdulaziz University(KAU)Hospital,Jeddah,Kingdom of Saudi Arabia[J].Electron Physician,2017,9(9):5185-5190.DOI:10.19082/5185.
[15] Heit JA,Leibson CL,Ashrani AA,et al.Is diabetes mellitus an independent risk factor for venous thromboembolism?:a population-based case-control study[J].Arterioscler Thromb Vasc Biol,2009,29(9):1399-1405.DOI:10.1161/ATVBAHA.109.189290.
[16] Volpe CMO,Villar-Delfino PH,Dos Anjos PMF,et al.Cellular death,reactive oxygen species(ROS)and diabetic complications[J].Cell Death Dis,2018,9(2):119.DOI:10.1038/s41419-017-0135-z.
[17] Prandoni P.Is there a link between venous and arterial thrombosis? a reappraisal[J].Intern Emerg Med,2020,15(1):33-36.DOI:10.1007/s11739-019-02238-6.
[18] Poredosˇ P.Interrelationship between venous and arterial thrombosis[J].Int Angiol,2017,36(4):295-298.DOI:10.23736/S0392-9590.17.03820-2.
[19] Morelli VM,de Mutsert R,de Roos A,et al.Association between hepatic triglyceride content and coagulation factors:the Netherlands Epidemiology of Obesity Study[J].Arterioscler Thromb Vasc Biol,2020,40(12):3004-3014.DOI:10.1161/ATVBAHA.120.315365.
[20] Sung Y,Spagou K,Kafeza M,et al.Deep vein thrombosis exhibits characteristic serum and vein wall metabolic phenotypes in the inferior vena cava ligation mouse model[J].Eur J Vasc Endovasc Surg,2018,55(5):703-713.DOI:10.1016/j.ejvs.2018.01.027.

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备注/Memo

备注/Memo:
基金项目:山东省中医药科技发展计划(2019-0559,2019-0660); 济南市卫生健康委员会科技计划项目(2019-1-23)
通信作者:王玉涛,Email:jnwangyutao@gmail.com
更新日期/Last Update: 2021-10-10