[1]张启伦,叶山东.SGLT2抑制剂肾脏外糖代谢调控机制的研究进展[J].国际内分泌代谢杂志,2021,41(04):360-363.[doi:10.3760/cma.j.cn121383-20200715-07040]
 Zhang Qilun,Ye Shandong..Research progress of the extrarenal mechanism of SGLT2 inhibitors in the regulation of blood glucose[J].International Journal of Endocrinology and Metabolism,2021,41(04):360-363.[doi:10.3760/cma.j.cn121383-20200715-07040]
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SGLT2抑制剂肾脏外糖代谢调控机制的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年04期
页码:
360-363
栏目:
综述
出版日期:
2021-07-20

文章信息/Info

Title:
Research progress of the extrarenal mechanism of SGLT2 inhibitors in the regulation of blood glucose
作者:
张启伦12叶山东1
1中国科学技术大学附属第一医院(安徽省立医院)内分泌科,糖尿病研究室,合肥 230001; 2中国科学技术大学生命科学与医学部,合肥 230027
Author(s):
Zhang Qilun12 Ye Shandong1.
1Laboratory of Diabetes,Department of Endocrinology, the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital),Hefei 230001, China; 2Divison of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China
关键词:
2型糖尿病 钠-葡萄糖协同转运蛋白2抑制剂 糖代谢
Keywords:
Type 2 diabetes mellitus Sodium-glucose cotransporter 2 inhibitor Glucose metabolism
DOI:
10.3760/cma.j.cn121383-20200715-07040
摘要:
钠-葡萄糖协同转运蛋白2抑制剂(SGLT2i)是一类新型的口服降血糖药物,其除了良好的降糖效果,还能降低血尿酸、尿蛋白排泄、血压和体重等,有效降低2型糖尿病患者的心、肾等并发症的发病风险。以往的观点认为,SGLT2i的降糖作用主要通过抑制肾脏近端小管葡萄糖的重吸收,从而降低肾糖阈,促进尿糖排泄,降低血糖。最近几年人们发现,SGLT2其实在多种组织广泛表达,如胰腺、肝脏等,SGLT2i对能量代谢的调控作用还存在其他机制,对此的深入了解可为其在治疗糖尿病的应用提供新的认识。
Abstract:
Sodium-glucose cotransporter 2 inhibitors(SGLT2i)is a new class of oral hypoglycemic drugs. In addition to its excellent hypoglycemic effect, it can also reduce blood uric acid, urine protein excretion, blood pressure and weight, etc, and effectively reduce the risk of cardiovascular disease, kidney disease and other complications of patients with type 2 diabetes mellitus. The previous view is that SGLT2i reduces the renal glucose threshold by inhibiting the reabsorption of glucose in the proximal tubule of the kidney, thereby promoting urinary glucose excretion and reducing blood glucose. In recent years, it has been found that SGLT2 is actually widely expressed in various tissues, such as pancreas and liver. The regulation effect of SGLT2i on energy metabolism is far beyond its effect in inhibiting the reabosption of glucose in the proximal tubule. Further learning of the hypoglycemic mechanism of SGLT2i besides the kidney can provide a new understanding for its application in the treatment of diabetes.

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备注/Memo

备注/Memo:
基金项目:安徽省中央引导地方科技发展专项(2017070802D147); 国家自然科学基金(81800713)
通信作者:叶山东,Email:ysd196406@163.com
更新日期/Last Update: 1900-01-01