[1]何桥玲 陈桂兰 陈家琪 张振 孙嘉 陈宏.白脂素在2型糖尿病发生及发展中的作用[J].国际内分泌代谢杂志,2020,40(04):267-270.[doi:10.3760/cma.j.issn.1673-4157.2020.04.012]
 He Qiaoling,Chen Guilan,Chen Jiaqi,et al.Roles of asprosin in the occurence and development of type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2020,40(04):267-270.[doi:10.3760/cma.j.issn.1673-4157.2020.04.012]
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白脂素在2型糖尿病发生及发展中的作用
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
40
期数:
2020年04期
页码:
267-270
栏目:
基础研究
出版日期:
2020-07-20

文章信息/Info

Title:
Roles of asprosin in the occurence and development of type 2 diabetes mellitus
作者:
何桥玲 陈桂兰 陈家琪 张振 孙嘉 陈宏
南方医科大学珠江医院内分泌代谢科,广州 510282
Author(s):
He Qiaoling Chen Guilan Chen Jiaqi Zhang Zhen Sun Jia Chen Hong
Department of Endocrinology and Metabolism, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
关键词:
白脂素 2型糖尿病 胰岛素抵抗 动脉粥样硬化
Keywords:
Asprosin Type 2 diabetes mellitus Insulin resistance Atherosclerosis
DOI:
10.3760/cma.j.issn.1673-4157.2020.04.012
摘要:
研究显示,白脂素与多种代谢性疾病如2型糖尿病、肥胖症、多囊卵巢综合征等密切相关。白脂素对2型糖尿病的影响主要通过结合于肝细胞表面激活G蛋白耦联受体,促进肝糖输出; 穿过血-脑屏障,激活下丘脑agouti相关神经肽阳性神经元,促进食欲; 诱导炎性反应,干扰胰岛素信号通路; 促进胰岛素抵抗。另外,白脂素还与动脉粥样硬化及糖尿病心脏微血管内皮损伤相关,表明其可能参与糖尿病血管病变的发生、发展。
Abstract:
Current studies have shown that asprosin is closely related to a variety of metabolic diseases such as type 2 diabetes mellitus(T2DM), obesity and polycystic ovary syndrome. Effects of asprosin on T2DM include binding G protein-coupled receptor(GPCR)on the surface of hepatocytes in order to promote hepatic glucose output; crossing the blood-brain barrier to stimulate agouti related peptide(AgRP)neurons in the hypothalamus and then promoting appetite; inducing inflammatory response to interfere the insulin signal pathway; enhancing insulin resistance. It has been proven that asprosin is also associated with atherosclerosis and the injury of cardiac microvascular endothelial cells induced by diabetes mellitus, indicating that it plays a vital role in the occurrence and development of diabetic vascular diseases.

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备注/Memo

备注/Memo:
通信作者:陈宏,Email: chenhong123@smu.edu.cn
基金项目:国家自然科学基金(81570716,8177030041); 广州市科技基金(201803040012)
Corresponding author:Chen Hong, Email: chenhong123@smu.edu.cn
Fund program:National Natural Science Foundation of China(81570716, 8177030041); Science and Technology Program of Guangzhou Province of China(201803040012)
更新日期/Last Update: 2020-07-20