[1]韩亮 吴凡 陈广.胎球蛋白在非酒精性脂肪性肝病和2型糖尿病中的作用[J].国际内分泌代谢杂志,2018,38(06):419-422.[doi:10.3760/cma.j.issn.1673-4157.2018.06.015]
 Han Liang*,Wu Fan,Chen Guang.Roles of fetuins in non-alcoholic fatty liver disease and type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2018,38(06):419-422.[doi:10.3760/cma.j.issn.1673-4157.2018.06.015]
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胎球蛋白在非酒精性脂肪性肝病和2型糖尿病中的作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年06期
页码:
419-422
栏目:
基础研究
出版日期:
2018-11-20

文章信息/Info

Title:
Roles of fetuins in non-alcoholic fatty liver disease and type 2 diabetes mellitus
作者:
韩亮 吴凡 陈广
作者单位:430030 武汉,华中科技大学同济医学院附属同济医院中西医临床专业2014级(韩亮),中西医结合研究所(吴凡),中西医结合科(陈广)
Author(s):
Han Liang* Wu Fan Chen Guang
*Integrated Traditional Chinese and Western Clinical Medicine Specialty of Grade 2014, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
关键词:
胎球蛋白 非酒精性脂肪性肝病 2型糖尿病 胰岛素抵抗
Keywords:
Fetuins Non-alcoholic fatty liver disease Type 2 diabetes mellitus Insulin resistance
DOI:
10.3760/cma.j.issn.1673-4157.2018.06.015
摘要:
胎球蛋白主要由肝脏分泌,在代谢、生殖等方面均发挥重要作用。近来研究发现,非酒精性脂肪性肝病和2型糖尿病患者体内胎球蛋白水平升高。胎球蛋白可通过抑制胰岛素信号通路、抑制脂联素表达、作为Toll样受体(TRL)4配体等多种途径介导的胰岛素抵抗和慢性代谢性炎性反应,进而参与非酒精性脂肪性肝病和2型糖尿病的发生、发展。对胎球蛋白进一步的研究,可为上述疾病的发病机制研究和相关慢性代谢性疾病的防治提供新的思路。
Abstract:
Fetuins are mainly secreted by the liver, which play important roles in the aspect of metabolism, reproduction, etc. Recent studies had revealed that fetuins level increased in patients with non-alcoholic fatty liver disease and type 2 diabetes mellitus. Moreover, fetuin-associated insulin resistance and chronic metabolic inflammation mediated by inhibiting insulin signal pathway, inhibiting expression of adiponectin,acting as a ligand of Toll like receptor 4 and other ways strongly promote the two diseases. Further studies on fetuins may provide new insights in the prevention and treatment of chronic metabolic diseases.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81774259,81403254)
Fund program:National Natural Science Foundation of China(81774259,81403254)
作者单位:430030 武汉,华中科技大学同济医学院附属同济医院中西医临床专业2014级(韩亮),中西医结合研究所(吴凡),中西医结合科(陈广)
通信作者:陈广,Email:guangchen@tjh.tjmu.edu.cn
更新日期/Last Update: 2018-12-30