[1]张珊,张洁,傅力.2型糖尿病患者血清脂联素与肝脏脂肪 含量的相关性研究[J].国际内分泌代谢杂志,2017,37(03):155-158.[doi:10.3760/cma.j.issn.1673-4157.2017.03.003]
　Zhang Shan*,Zhang Jie,Fu Li..The correlation analysis between serum adiponectin level and liver fat content in patients with type 2 diabetes[J].International Journal of Endocrinology and Metabolism,2017,37(03):155-158.[doi:10.3760/cma.j.issn.1673-4157.2017.03.003]
点击复制

2型糖尿病患者血清脂联素与肝脏脂肪 含量的相关性研究()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年03期
页码:
155-158
栏目:
论著
出版日期:
2017-05-20

文章信息/Info

Title:
The correlation analysis between serum adiponectin level and liver fat content in patients with type 2 diabetes
作者:
张珊; 张洁; 傅力
300070 天津医科大学生理学与病理生理学系(张珊,傅力); 300170 天津市第三中心医院内分泌科(张洁)
Author(s):
Zhang Shan*;  Zhang Jie;  Fu Li.
*Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300070, China
关键词:
2型糖尿病;  脂联素;  胰岛素抵抗;  脂肪肝
Keywords:
Type 2 diabetes mellitus;  Adiponectin;  Insulin resistance;  Fatty liver disease
DOI:
10.3760/cma.j.issn.1673-4157.2017.03.003
摘要:
目的 探讨 2 型糖尿病患者血清脂联素水平与肝脏脂肪含量及相关临床指标的相关性。方法 选取天津市第三中心医院收治的初发2型糖尿病患者108例,以患者肝脏脂肪含量测定结果的平均数为切点将其分为2型糖尿病伴低肝脏脂肪含量组(T2DM+LFC组)50例和2型糖尿病伴高肝脏脂肪含量组(T2DM+HFC组)58例。应用高效液相层析法、葡萄糖氧化酶法、放射免疫法以及ELISA等分别对两组患者的相关临床指标及血清脂联素水平进行检测。采用t检验或χ2检验进行组间对比,采用Spearman相关分析和多元逐步回归分析进行指标间关系判定,采用Logistic回归分析影响肝脏脂肪含量的危险因素。结果 T2DM+HFC组血清脂联素水平显著低于T2DM+LFC组(t=3.947,P=0.006)。 2型糖尿病患者血清脂联素水平与体重、体重指数、体脂含量、内脏脂肪面积、肝脏脂肪含量、甘油三酯水平呈显著负相关(r=-0.680～-0.225,P<0.05或0.01)。多元逐步回归分析显示,体重、体重指数和体脂含量是血清脂联素水平的独立相关因素。Logistic回归分析显示,体重(OR=1.288, 95% CI: 1.009～1.644)、脂联素(OR=0.169, 95% CI: 0.053～0.542)、γ-谷氨酰胺转肽酶(OR=1.155, 95% CI: 1.032～1.293)及甘油三酯(OR=0.323, 95% CI: 0.172～0.609)为2型糖尿病患者肝脏脂肪含量的影响因素。结论 血清脂联素水平与体重、体重指数和体脂含量密切相关,并可能在2型糖尿病患者肝脏脂质沉积过程中发挥重要调节作用。
Abstract:
Objective To investigate the relationship between serum adiponectin level and liver fat content as well as other related clinical parameters in patients with type 2 diabetes.Methods A total of 108 patients newly diagnosed with type 2 diabetes in the Third Central Hospital of Tianjin were selected. According to the liver fat content, subjects were divided into type 2 diabetic patients with low liver fat content group(T2DM+LFC group,n=50)and type 2 diabetic patients with high liver fat content group(T2DM+HFC group,n=58). The related clinical indexes and serum adiponectin level were measured by high performance liquid chromatography, glucose oxidase method, radioimmunoassay or ELISA. Comparison between groups were using t test or χ2 test. Spearman correlation analysis and multiple stepwise regression analysis were used to determine the relationship between indexes. Logistic regression analysis was used to analyze the risk factors of liver fat content. Results The level of serum adiponectin in T2DM+HFC group was significantly lower than that in T2DM+LFC group(t=3.947, P=0.006). The level of serum adiponectin was negatively correlated with body weight, body mass index, body fat, visceral fat area, liver fat content, and triglyceride in type 2 diabetic patients(r=-0.680--0.225, P<0.05 or 0.01). Stepwise regression indicated that body weight, body mass index and body fat content were independent correlated factors of serum adiponectin level. Logistic regression analysis showed that body weight(OR=1.288, 95% CI: 1.009-1.644), adiponectin(OR=0.169, 95% CI: 0.053-0.542), γ-glutamine transpeptidase(OR=1.155, 95% CI: 1.032-1.293)and triyglyceride(OR= 0.323, 95% CI: 0.172-0.609)were risk factors for liver fat content in patients with type 2 diabetes.Conclusion Level of serum adiponectin is affected by body weight, body mass index and body fat content, and may play an important role in lipid deposition in the liver of type 2 diabetic patients.

参考文献/References:

[1] Wang ZV, Scherer PE. Adiponectin, the past two decades[J].J Mol Cell Biol,2016,8(2):93-100. DOI: 10.1093/jmcb/mjw011.
[2] Polyzos SA, Kountouras J, Mantzoros CS. Adipokines in nonalcoholic fatty liver disease[J].Metabolism,2016,65(8):1062-1079. DOI: 10.1016/j.metabol.2015.11.006.
[3] Webb M, Yeshua H, Zelber-Sagi S,et al. Diagnostic value of a computerized hepatorenal index for sonographic quantification of liver steatosis[J]. Am J Roentgenol,2009,192(4):909-914. DOI: 10.2214/AJR.07.4016.
[4] Içer S, Co �瘙 塂 kun A, Ikizceli T. Quantitative grading using Grey Relational Analysis on ultrasonographic images of a fatty liver[J].J Med Syst,2012,36(4):2521-2528. DOI: 10.1007/s10916-011-9724-z.
[5] Xia MF, Yan HM, He WY,et al. Standardized ultrasound hepatic/renal ratio and hepatic attenuation rate to quantify liver fat content: an improvement method[J].Obesity(Silver Spring),2012,20(2):444-452. DOI:10.1038/oby.2011.302.
[6] Shibata M, Kihara Y, Taguchi M,et al. Nonalcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men[J].Diabetes Care,2007,30(11):2940-2944. DOI:10.2337/dc07-0792.
[7] Machado M, Cortez-Pinto H. Non-alcoholic fatty liver disease and insulin resistance[J].Eur J Gastroenterol Hepatol,2005,17(8):823-826.DOI:10.1097/00042737-200508000-00008.
[8] Poulsen MK, Nellemann B, Stødkilde-Jørgensen H,et al. Impaired insulin suppression of VLDL-triglyceride kinetics in nonalcoholic fatty liver disease[J].J Clin Endocrinol Metab,2016,101(4):1637-1646. DOI: 10.1210/jc.2015-3476.
[9] Videla LA, Pettinelli P. Misregulation of PPAR functioning and its pathogenic consequences associated with nonalcoholic fatty liver disease in human obesity[J].PPAR Res,2012,2012:107434. DOI: 10.1155/2012/107434.
[10] Birkenfeld AL, Shulman GI. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes[J].Hepatology,2014,59(2):713-723. DOI:10.1002/hep.26672.
[11] Ayeser T, Basak M, Arslan K,et al. Investigating the correlation of the number of diagnostic criteria to serum adiponectin, leptin, resistin, TNF-alpha, EGFR levels and abdominal adipose tissue[J].Diabetes Metab Syndr,2016,10(2 Suppl 1):S165-S169. DOI:10.1016/j.dsx.2016.03.010.
[12] Chandrasekar B, Boylston WH, Venkatachalam K,et al. Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase(AMPK)activation and IKK/NF-kappaB/PTEN suppression[J].J Biol Chem,2008,283(36):24889-24898. DOI: 10.1074/jbc.M804236200.
[13] Bozzetto L, Prinster A, Mancini M,et al. Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution[J].Eur J Clin Invest,2011,41(1):39-44. DOI: 10.1111/j.1365-2362.2010.02372.x.

相似文献/References:

[1]曾静波,王姮.2型糖尿病与自身免疫反应[J].国际内分泌代谢杂志,2007,(04):259.
[2]朱素君,谢锦桃,刘军,等.二甲双胍：2型糖尿病治疗的基础药[J].国际内分泌代谢杂志,2007,(04):280.
[3]刘艳清 易秋艳 邵加庆.肠道菌群与肥胖和糖尿病的关系[J].国际内分泌代谢杂志,2015,(01):31.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.007]
　Liu Yanqing,Yi Qiuyan,Shao Jiaqing..Relationship between gut microbiota, obesity and diabetes[J].International Journal of Endocrinology and Metabolism,2015,(03):31.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.007]
[4]姚旻 赵爱源 张宏.肠道菌群与2型糖尿病[J].国际内分泌代谢杂志,2015,(01):35.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.008]
　Yao Min*,Zhao Aiyuan,Zhang Hong..Relationship between gut microbiota and type 2 diabetes[J].International Journal of Endocrinology and Metabolism,2015,(03):35.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.008]
[5]赵丽娟,徐宽枫,杨涛,等.SLC30A8和PTPRD基因多态性与南京地区中老年人群2型糖尿病的相关性研究[J].国际内分泌代谢杂志,2015,(03):145.[doi:10.3760/cma.j.issn.1673-4157.2015.03.001]
　Zhao Lijuan*,Xu Kuanfeng,Yang Tao,et al.Relationship between SLC30A8 and PTPRD gene polymorphisms and type 2 diabetes in middle aged and elderly people in Nanjing area[J].International Journal of Endocrinology and Metabolism,2015,(03):145.[doi:10.3760/cma.j.issn.1673-4157.2015.03.001]
[6]王洁,何媛,于珮.糖尿病肾病的相关危险因素分析[J].国际内分泌代谢杂志,2015,(03):153.[doi:10.3760/cma.j.issn.1673-4157.2015.03.003]
　Wang Jie*,He Yuan,Yu Pei..Risk factors of diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(03):153.[doi:10.3760/cma.j.issn.1673-4157.2015.03.003]
[7]刘帅,张萍,方毅,等.2型糖尿病合并无症状冠状动脉钙化的相关危险因素分析[J].国际内分泌代谢杂志,2015,(03):158.[doi:10.3760/cma.j.issn.1673-4157.2015.03.004]
　Liu Shuai*,Zhang Ping,Fang Yi,et al.Analysis of the risk factors related with asymptomatic coronary calcification for type 2 diabetic patients[J].International Journal of Endocrinology and Metabolism,2015,(03):158.[doi:10.3760/cma.j.issn.1673-4157.2015.03.004]
[8]徐庆海,马颖,李铁马.2型糖尿病患者高甘油三酯血症-腰围表型与甲状腺功能异常的关系[J].国际内分泌代谢杂志,2015,(04):222.[doi:10.3760/cma.j.issn.1673-4157.2015.04.002]
　Xu Qinghai,Ma Ying,Li Tiema..Association of hypertriglyceridaemic-waist phenotype with thyroid dysfunction in patients with type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2015,(03):222.[doi:10.3760/cma.j.issn.1673-4157.2015.04.002]
[9]潘道延,沈洁,朱筱,等.利格列汀对2型糖尿病大鼠代谢性内毒素血症的影响[J].国际内分泌代谢杂志,2015,(04):230.[doi:10.3760/cma.j.issn.1673-4157.2015.04.004]
　Pan Daoyan,Shen Jie,Zhu Xiao,et al.Effects of linagliptin on metabolic endotoxemia in type 2 diabetic rats[J].International Journal of Endocrinology and Metabolism,2015,(03):230.[doi:10.3760/cma.j.issn.1673-4157.2015.04.004]
[10]黄桥,白洁,杜洪泉.一种新的脂肪细胞因子——cartonectin[J].国际内分泌代谢杂志,2015,(04):265.[doi:10.3760/cma.j.issn.1673-4157.2015.04.014]
　Huang Qiao*,Bai Jie,Du Hongquan..A novel adipokine--cartonectin[J].International Journal of Endocrinology and Metabolism,2015,(03):265.[doi:10.3760/cma.j.issn.1673-4157.2015.04.014]

备注/Memo

备注/Memo:
通信作者:傅力,Email:lifu@tmu.edu.cn
更新日期/Last Update: 2017-05-20