[1]周欢欢,徐书杭,刘超,等.肠促胰素类降糖药物对体重的作用[J].国际内分泌代谢杂志,2016,36(03):172-171.[doi:10.3760/cma.j.issn.1673-4157.2016.03.07]
 Zhou Huanhuan*,Xu Shuhang,Liu Chao,et al.Effects of incretin drugs on body weight[J].International Journal of Endocrinology and Metabolism,2016,36(03):172-171.[doi:10.3760/cma.j.issn.1673-4157.2016.03.07]
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肠促胰素类降糖药物对体重的作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年03期
页码:
172-171
栏目:
综述
出版日期:
2016-05-20

文章信息/Info

Title:
Effects of incretin drugs on body weight
作者:
周欢欢徐书杭刘超楼青青
210023 南京中医药大学护理学院(周欢欢); 210028 江苏省中医药研究院,南京中医药大学附属中西医结合医院内分泌代谢病院区(徐书杭,刘超),健康教育科(楼青青)
Author(s):
Zhou Huanhuan* Xu Shuhang Liu Chao Lou Qingqing.
</sup>*College of Nursing,Nanjing University of Chinese Medicine, Nanjing 210023, China
关键词:
2型糖尿病 胰高血糖素样肽-1受体激动剂 二肽基肽酶-4抑制剂 体重
Keywords:
Type 2 diabetes mellitus Glucagon-like peptide 1 receptor agonists Dipepidyl peptidase 4 inhibitors Body weight
DOI:
10.3760/cma.j.issn.1673-4157.2016.03.07
摘要:
胰高血糖素样肽-1(GLP-1)受体激动剂和二肽基肽酶-4(DPP-4)抑制剂是新型的2型糖尿病治疗药物。普遍认为,GLP-1受体激动剂可显著减轻患者体重,DPP-4抑制剂对体重的作用为中性。然而,这两类药物与不同药物联用,患者体重可不同程度增加,尤其是与磺脲类或噻唑烷二酮类药物联用时。临床医师应了解GLP-1受体激动剂和DPP-4抑制剂对体重的影响,为2型糖尿病患者制定更合理、安全和有效的治疗方案。
Abstract:
Incretins including glucagon-like peptide-1(GLP-1)receptor agonists and dipeptidyl peptidase Ⅳ(DPP-4)inhibitors are a new type of anti-hyperglycemic drugs. Generally speaking, GLP-1 analogues are associated with significant weight loss, and DPP-4 inhibitors have a neutral effect on body weight. However, they still cause weight gain, particularly when combined with sulfonylureas or thiazolidinedione. Clinicians should be aware of the influence on body weight of GLP-1 analogues and DPP-4 inhibitors, which can lay the foundation for developing more rational, safe and effective treatments for patients with type 2 diabetes.

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更新日期/Last Update: 2016-05-20