[1]陆丽华,董跃滨,徐晖.2型糖尿病患者幽门螺杆菌感染率的 荟萃分析[J].国际内分泌代谢杂志,2016,36(02):124-127.[doi:10.3760/cma.j.issn.1673-4157.2016.02.012]
　Lu Lihua,Dong Yuebin,Xu Hui..Prevalence of Helicobacter pylori in type 2 diabetic patients:a meta-analysis[J].International Journal of Endocrinology and Metabolism,2016,36(02):124-127.[doi:10.3760/cma.j.issn.1673-4157.2016.02.012]
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2型糖尿病患者幽门螺杆菌感染率的 荟萃分析()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年02期
页码:
124-127
栏目:
荟萃分析
出版日期:
2016-03-20

文章信息/Info

Title:
Prevalence of Helicobacter pylori in type 2 diabetic patients:a meta-analysis
作者:
陆丽华; 董跃滨; 徐晖
200137 上海中医药大学附属第七人民医院消化内科
Author(s):
Lu Lihua;  Dong Yuebin; Xu Hui.
Department of Gastroenterology, Seventh People's Hospital of Shanghai University of TCM, Shanghai 200137, China
关键词:
2型糖尿病;  幽门螺杆菌;  感染率;  荟萃分析
Keywords:
Type 2 diabetes mellitus;  Helicobacter pylori;  Prevalence;  Meta-analysis
DOI:
10.3760/cma.j.issn.1673-4157.2016.02.012
摘要:
目的 探索2型糖尿病患者幽门螺杆菌(H.pylori)感染的感染率。方法 检索美国医学索引(MedLine)和荷兰医学文摘(EMBASE)1990年1月至2015年5月公开发表的关于2型糖尿病患者及对照组的H.pylori感染率的相关研究。分别由2位研究者以NOS评定量表(Newcastle-Ottawa Quality Assessment Scale)为依据进行质量评价,选用随机效应模型,使用STATA 12.0软件计算OR值(95%CI)。结果 共有13项研究符合纳入标准,与对照组相比,2型糖尿病患者经荟萃分析后的H.pylori感染的OR值为1.70,95%CI为1.30～2.22(P=0.013)。亚洲区T2DM亚组的H.pylori感染率高于对照组(OR=1.81,95% CI:1.25～2.61,P=0.025)。胃黏膜活检T2DM亚组的H.pylori感染率高于对照组(OR=1.65,95% CI:1.10～2.46,P=0.002)。结论 2型糖尿病患者H.pylori感染风险增加。
Abstract:
Objective To systematically assess the prevalence of Helicobacter pylori in patients with type 2 diabetes mellitus. Methods Medline(PubMed)and EMBASE data-bases were searched from January 1990 to May 2015. Studies that provided data on Helicobacter pylori infection rate in both type 2 diabetes and control groups were selected. The quality of these studies was assessed using the Newcastle-Ottawa Quality Assessment Scale by two researchers, respectively. Meta-analysis was performed using the random effects model. Odd ratios(OR)and 95% Confidence Interval(CI)were calculated by STATA 12.0. Results Thirteen studies were included, OR of Helicobacter pylori infection rate was 1.70(95% CI: 1.30-2.22,P=0.013)in patients with type 2 diabetes compared with control group. In subgroup analysis, the prevalence of Helicobacter pylori was higher in patients in Asia compared with control group(OR = 1.81,95% CI: 1.25-2.61,P=0.025). The prevalence of Helicobacter pylori was higher in diabetic patients in gastric mucosal biopsy group compared with control group(OR=1.65,95% CI:1.10-2.46,P=0.002).Conclusion Patients with type 2 diabetes mellitus may have a higher risk of Helicobacter pylori infection.

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更新日期/Last Update: 2016-03-20