[1]范乐平,宋轶萱,邱慧娜,等.维生素D缺乏与糖尿病周围神经病变的 相关性研究[J].国际内分泌代谢杂志,2016,36(02):96-100.[doi:10.3760/cma.j.issn.1673-4157.2016.02.006]
　Fan Leping,Song Yixuan,Qiu Huina,et al.The relationship between vitamin D deficiency and diabetic peripheral neuropathy[J].International Journal of Endocrinology and Metabolism,2016,36(02):96-100.[doi:10.3760/cma.j.issn.1673-4157.2016.02.006]
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维生素D缺乏与糖尿病周围神经病变的 相关性研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年02期
页码:
96-100
栏目:
论著
出版日期:
2016-03-20

文章信息/Info

Title:
The relationship between vitamin D deficiency and diabetic peripheral neuropathy
作者:
范乐平; 宋轶萱; 邱慧娜; 朱杰; 林静娜
300121 天津市人民医院内分泌科
Author(s):
Fan Leping;  Song Yixuan;  Qiu Huina;  Zhu Jie;  Lin Jingna.
Department of Endocrinology, Tianjin People's Hospital, Tianjin 300121, China
关键词:
2型糖尿病;  维生素D缺乏;  周围神经病变
Keywords:
Type 2 diabetes mellitus;  Vitamin D deficiency;  Peripheral neuropathy
DOI:
10.3760/cma.j.issn.1673-4157.2016.02.006
摘要:
目的 研究2型糖尿病患者维生素D缺乏与糖尿病周围神经病变(DPN)的相关性。方法 选取2型糖尿病患者200例和正常对照者100名,其中2型糖尿病患者分为DPN组(109例)和无糖尿病周围神经病变(NDPN)组(91例)。通过ELISA法测定25(OH)D3水平,常规测定肝、肾功能,HbA1c,血脂,血钙、磷,β2微球蛋白,尿微量白蛋白等指标。25(OH)D3与各指标之间进行相关性分析。结果 与正常对照组相比,NDPN组和DPN组25(OH)D3水平降低,DPN组降低更加明显(F=202.265,P<0.01),且DPN组维生素D缺乏患者比例(76.1%)明显高于NDPN组(47.3%)(χ2=17.763,P<0.01)。维生素D水平与DPN、病程、年龄、性别、空腹血糖、HbA1c、总胆固醇、低密度脂蛋白-胆固醇、24 h尿微量白蛋白、β2微球蛋白均呈显著负相关(r=-0.315～-0.144, P均<0.05),而与血钙呈正相关(r=0.193,P=0.006)。二元Logistic回归分析显示,维生素D缺乏是DPN的独立危险因素(OR=3.564,95%CI:1.950～6.511,P<0.001)。结论 维生素D缺乏是DPN的独立危险因子,并可能在2型糖尿病及DPN的发生、发展中发挥作用。
Abstract:
Objective To study the association of vitamin D deficiency with diabetic peripheral neuropathy(DPN)in type 2 diabetic patients. Methods A total of 200 type 2 diabetic patients and 100 healthy normal people were included in this study. Patients with type 2 diabetes were divided into DPN group(n=109)and non-DPN group(NDPN group, n=91). ELISA was used to measure the level of 25(OH)D3, and conventional methods were used to determine the functions of liver and renal, glycosylated hemoglobin, blood lipid, serum calcium, phosphorus, beta 2 microglobulin, urinary microalbumin and other indicators. Correlation analysis between 25(OH)3 and other indicators were performed. Results Compared with normal control group, levels of 25(OH)D3 in NDPN group and DPN group were lower, especially in DPN group(F=202.265,P<0.01). Moreover, the percentage of vitamin D deficiency in DPN group(76.1%)was much higher than that of NDPN group(47.3%, χ2=17.763,P<0.001). Level of vuitamin D was negatively related to DPN, diabetic duration, age, gender, fasting blood glucose, HbA1c, total cholesterol, low density lipoprotein cholesterol, 24 h urinary microalbumin, beta 2 microglobulin(r=-0.315 to-0.144, all P<0.05), and positively related to blood calcium(r=0.193,P=0.006). Binary Logistic regression analysis showed that vitamin D deficiency was an independent risk factor for DPN(OR=3.564, 95%CI: 1.950-6.511,P<0.001). Conclusion Vitamin D deficiency is an independent risk factor for DPN, and may play a role in the occurrence and development of type 2 diabetes and DPN.

参考文献/References:

[1] Deshpande AD, Harris-Hayes M, Schootman M. Epidemiology of diabetes and diabetes-related complications[J].Phys Ther,2008,88(11):1254-1264.DOI:10.2522/ptj.20080020.
[2] Skalli S, Muller M, Pradines S,et al. Vitamin D deficiency and peripheral diabetic neuropathy[J].Eur J Intern Med, 2012,23(2):e67-e68. DOI: 10.1016/j.ejim.2011.11.008.
[3] Adams JS, Hewison M. Update in vitamin D[J]. J Clin Endocr Metab, 2010, 95(2): 471-478. DOI:10.1210/jc.2009-1773.
[4] Hewison M. Vitamin D and the intracrinology of innate immunity[J]. Mol Cell Endocrinol, 2010, 321(2): 103-111. DOI: 10.1016/j.mce.2010.02.013.
[5] Makariou S, Liberopoulos EN, Elisaf M, et al. Novel roles of vitamin D in disease: what is new in 2011[J]. Eur J Intern Med, 2011, 22(4): 355-362.DOI:10.1016/j.ejim.2011.04.012.
[6] Shehab D, Al-Jarallah K, Mojiminiyi O, et al. Does vitamin D deficiency play a role in peripheral neuropathy in type 2 diabetes? [J].Diabetic Med,2012,29(1):43-49.DOI:10.1111/j.1464-5491.2011.03510.x.
[7] Ahmadieh H, Azar ST, Lakkis N, et al. Hypovitaminosis D in patients with type 2 diabetes mellitus: a relation to disease control and complications[J].ISRN Endocrinol,2013,2013. DOI: 10.1155/2013/641098.
[8] Palomer X, González-Clemente J, Blanco-Vaca F, et al. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus[J]. Diabetes Obes Metab, 2008, 10(3): 185-197.DOI:10.1111/j.1463-1326.2007.00710.x.
[9] Moreira TS, Hamadeh MJ. The role of vitamin D deficiency in the pathogenesis of type 2 diabetes mellitus[J]. e-SPEN, Euro e-J Clin Nutr Metab, 2010, 5(4): e155-e165. DOI:10.1016/j.eclnm.2010.05.001.
[10] Choi M, Ozeki J, Hashizume M, et al. Vitamin D receptor activation induces peptide YY transcription in pancreatic islets[J]. Endocrinology, 2012, 153(11): 5188-5199. DOI:10.1210/en.2012-1396.
[11] Mathieu C, Adorini L.The coming of age of 1,25-dihydroxyvitamin D3 analogs as immunomodulalory agents[J].Trends Mol Med,2002,8(4):174-179.DOI:10.1016/S1471-4914(02)02294-3.
[12] Li AC,Glass CK. The macrophage foam cell as a large for therapeutic intervention[J].Nal Med, 2002, 8(11):1235-1242. DOI:10.1038/nm1102-1235.
[13] McCarty MF. Secondary hyperparathyroidism promotes the acute phase response-a rationale for supplemental vitamin D in prevention of vascular events in the elderly[J]. Med Hypotheses, 2005, 64(5): 1022-1026.DOI:10.1016/j.mehy.2004.03.041.
[14] Boulton AJ, Malik RA.Diabetic neuropathy[J]. Med Clin North Am, 1998,82(4):909-929.DOI:10.1016/S0025-7125(05)70029-8.
[15] Riaz S, Malcangio M, Miller M, et al. A vitamin D3 derivative(CB1093)induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats[J]. Diabetologia, 1999, 42: 1308-1313.DOI:10.1007/s001250051443.
[16] Gursoy G, Cimbek A, Kirnap NG, et al. Relation of serum 25 hydroxy vitamin D3 levels with nephropathy in type 2 diabetic patients[J].Türkiye Klinikleri Endokrinoloji Dergisi, 2013, 8(2): 47-51. DOI:10.2337/dc14-0180.
[17] Trivedi JR, Silvestri NJ, Wolfe GI. Treatment of painful peripheral neuropathy[J].Neurol Clin,2013,31(2): 377-403.DOI:10.1016/j.ncl.2013.01.003.

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备注/Memo

备注/Memo:
基金项目:天津市卫生局科技基金项目(2015KZ058)
更新日期/Last Update: 2016-03-20