[1]曹萌 韦晓 刘超.自噬与胰岛β细胞功能及2型糖尿病[J].国际内分泌代谢杂志,2015,(01):53-55.[doi:10.3760/cma.j.issn.1673-4157.2015.01.013]
 Cao Meng,Wei Xiao,Liu Chao..Relationship between autophagy and islet β cells function, type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2015,(01):53-55.[doi:10.3760/cma.j.issn.1673-4157.2015.01.013]
点击复制

自噬与胰岛β细胞功能及2型糖尿病()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年01
页码:
53-55
栏目:
综述
出版日期:
2015-01-20

文章信息/Info

Title:
Relationship between autophagy and islet β cells function, type 2 diabetes mellitus
作者:
曹萌 韦晓 刘超
210028 南京,中国中医科学院江苏分院,南京中医药大学附属江苏省中西医结合医院内分泌代谢病院区
Author(s):
Cao Meng Wei Xiao Liu Chao.
Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Jiangsu Branch of China Academy of Chinese Medical Science, Nanjing 210028, ChinaCorresponding author:Liu Chao,Email:liuchao@jsatcm.com
关键词:
自噬 2型糖尿病 胰岛β细胞
Keywords:
Autophagy Type 2 diabetes mellitus Islet beta cells
DOI:
10.3760/cma.j.issn.1673-4157.2015.01.013
摘要:
β细胞衰竭是2型糖尿病发病的重要机制。自噬是一种细胞内的代谢降解过程,能够有效地降解胞内聚集的蛋白和损伤的细胞器。研究显示,抑制自噬会导致胰岛素分泌减少及高血糖。而刺激自噬则可以改善糖尿病、增加胰岛素分泌、防止β细胞凋亡。这些结果提示:自噬在维持内环境稳定,保护胰岛β细胞的结构和功能等方面发挥重要作用。除此之外,自噬在缓解胰岛素抵抗状态下的应激反应过程中也发挥重要作用。自噬功能的损伤会使个体更易于患2型糖尿病。
Abstract:
β cell failure is crucial in the onset of type 2 diabetes mellitus. Autophagy is a cellular degradation-recycling process for aggregated proteins and damaged organelles. Inhibition of autophagy causes insulin deficiency and hyperglycemia. Autophagy deficient mice shows degenerated β-cell and impaired glucose tolerance with reduced insulin secretion. Stimulating autophagy can improve diabetes, increase pancreatic insulin content, and prevent β-cell apoptosis. These results suggest that autophagy plays an important role in maintaining internal environmental stabilization, protecting architecture and function of islet β cells. Autophagy also serves as a crucial element of stress response under insulin-resistant states. Impairment of autophagic function could thus predispose individuals to type 2 diabetes mellitus.

参考文献/References:

[1] Ouimet M. Autophagy in obesity and atherosclerosis: interrelationships between cholesterol homeostasis, lipoprotein metabolism and autophagy in macrophages and other systems[J].Biochim Biophys Acta, 2013, 1831(6):1124-1133.
[2] Kim KH, Lee MS. Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism[J].Rev Endocr Metab Disord, 2014, 15(1):11-20.
[3] Gonzalez CD, Lee MS, Marchetti P, et al. The emerging role of autophagy in the pathophysiology of diabetes mellitus [J].Autophagy, 2011, 7(1):2-11.
[4]Ezaki J, Matsumoto N, Takeda-Ezaki M, et al. Liver autophagy contributes to the maintenance of blood glucose and amino acid levels[J].Autophagy, 2011, 7(7):727-736.
[5] 丁磊, 曹萌, 王立新. 细胞自噬参与蛋白降解及抗原递呈的研究进展 [J]. 国际免疫学杂志, 2009, 32(3):180-183.
[6] Choi AM, Ryter SW, Levine B. Autophagy in human health and disease[J]. N Engl J Med,2013, 368(7):651-662.
[7] Klionsky DJ, Abdalla FC, Abeliovich H, et al. Guidelines for the use and interpretation of assays for monitoring autophagy [J]. Autophagy, 2012, 8(4):445-544.
[8] Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues[J]. Cell, 2011, 147(4):728-741.
[9] Kroemer G, Marino G, Levine B. Autophagy and the integrated stress response[J]. Mol Cell, 2010, 40(2):280-293.
[10] Liu Y, Palanivel R, Rai E, et al. Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high fat diet feeding in mice[J]. Diabetes, 2014, [Epub ahead of print].
[11] Martino L, Masini M, Novelli M, et al. Palmitate activates autophagy in INS-1E beta-cells and in isolated rat and human pancreatic islets[J].PLoS One, 2012, 7(5):e36188.
[12] Pearson GL, Mellett N, Chu KY, et al. Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucosestimulated insulin secretion from pancreatic beta cells[J]. Diabetologia, 2014, 57(1):129-139.
[13] Jung HS, Chung KW, Won-Kim J, et al. Loss of autophagy diminishes pancreatic β cell mass and function with resultant hyperglycemia[J]. Cell Metab, 2008, 8(4):318-324.
[14] Ebato C, Uchida T, Arakawa M, et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet[J]. Cell Metab, 2008, 8(4):325-332.
[15] Choi SE, Lee SM, Lee YJ, et al. Protective role of autophagy in palmitate-induced INS-1 beta-cell death[J]. Endocrinology, 2009, 150(1):126-134.
[16] Quan W, Hur KY, Lim Y, et al. Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice[J]. Diabetologia, 2012, 55(2):392-403.
[17] Kaniuk NA, Kiraly M, Bates H, et al. Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy[J].Diabetes, 2007, 56(4):930-939.
[18] Masini M, Lupi R, Bugliani M, et al. A role for autophagy in β-cell life and death[J]. Islets, 2009, 1(2):157-159.
[19] Bachar-Wikstrom E, Wikstrom JD, Ariav Y, et al. Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes[J]. Diabetes, 62(4):1227-1237.
[20] Nair U, Jotwani A, Geng J, et al. SNARE proteins are required for macroautophagy [J]. Cell, 2011, 146(2):290-302.

相似文献/References:

[1]赵紫琴,雒瑢,田凤石,等.替米沙坦对OLETF大鼠皮下和内脏脂肪组织PPARγ表达的影响[J].国际内分泌代谢杂志,2014,(06):365.[doi:10.3760/cma.j.issn.1673-4157.2014.06.002]
 Zhao Ziqin*,Luo Rong,Tian Fengshi,et al.Effects of telmisartan on expression of PPARγ in subcutaneous and visceral adipose tissue in OLETF rats[J].International Journal of Endocrinology and Metabolism,2014,(01):365.[doi:10.3760/cma.j.issn.1673-4157.2014.06.002]
[2]姚霜霜,张翼飞,张志国,等.小檗碱改善代谢性疾病的肠道相关机制[J].国际内分泌代谢杂志,2014,(06):386.[doi:10.3760/cma.j.issn.1673-4157.2014.06.007]
 Yao Shuangshuang,Zhang Yifei,Zhang Zhiguo,et al.The gut-related mechanisms of berberine in the treatment of metabolic diseases[J].International Journal of Endocrinology and Metabolism,2014,(01):386.[doi:10.3760/cma.j.issn.1673-4157.2014.06.007]
[3]刘艳 田秀标 韩颖.GLP-1受体激动剂呈葡萄糖依赖性刺激胰岛β细胞胰岛素分泌的机制[J].国际内分泌代谢杂志,2015,(01):66.[doi:10.3760/cma.j.issn.1673-4157.2015.01.017]
 Liu Yan*,Tian Xiubiao,Han Ying..Mechanism of GLP-1 receptor agonists in the stimulation of insulin secretion of islet β cell in a glucose-dependent manner[J].International Journal of Endocrinology and Metabolism,2015,(01):66.[doi:10.3760/cma.j.issn.1673-4157.2015.01.017]
[4]吴彦菊,张捷,单春艳,等.Beclin1及Atg7在维格列汀保护db/db小鼠胰岛β细胞中的作用[J].国际内分泌代谢杂志,2014,(02):73.[doi:10.3760/cma.j.issn.1673-4157.2014.02.001]
 Wu Yanju*,Zhang Jie,Shan Chunyan,et al.The role of Beclin1 and Atg7 in the protective effect of vildagliptin on islet β cells of db/db mice[J].International Journal of Endocrinology and Metabolism,2014,(01):73.[doi:10.3760/cma.j.issn.1673-4157.2014.02.001]
[5]孙洁,杨兵全,孙子林.自噬与糖尿病骨骼肌病变[J].国际内分泌代谢杂志,2014,(03):194.[doi:10.3760/cma.j.issn.1673-4157.2014.03.014]
 Sun Jie*,Yang Bingquan,Sun Zilin..Autophagy in diabetic myopathy[J].International Journal of Endocrinology and Metabolism,2014,(01):194.[doi:10.3760/cma.j.issn.1673-4157.2014.03.014]
[6]李影,张真稳.线粒体损伤与糖尿病发病的相关机制[J].国际内分泌代谢杂志,2014,(04):271.[doi:10.3760/cma.j.issn.1673-4157.2014.04.016]
 Li Ying,Zhang Zhenwen..Relationship between mitochondrial damage and diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2014,(01):271.[doi:10.3760/cma.j.issn.1673-4157.2014.04.016]
[7]齐利琴,刘礼斌.GLP-1在2型糖尿病诱发的阿尔茨海默病治疗中的作用[J].国际内分泌代谢杂志,2016,36(01):48.[doi:10.3760/cma.j.issn.1673-4157.2016.01.012]
 Qi Liqin,Liu Libin..Effects of GLP-1 in the treatment of Alzheimer's disease induced by type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2016,36(01):48.[doi:10.3760/cma.j.issn.1673-4157.2016.01.012]
[8]梅稳,向光大,卢俊颜,等.GDF11对ApoE-/-糖尿病小鼠内皮依赖性 血管舒张功能的作用[J].国际内分泌代谢杂志,2016,36(02):101.[doi:10.3760/cma.j.issn.1673-4157.2016.02.007]
 Mei Wen*,Xiang Guangda,Lu Junyan,et al.Effects of GDF11 on endothelium-dependent vasodiation function of aorta in ApoE-/- diabetic mice[J].International Journal of Endocrinology and Metabolism,2016,36(01):101.[doi:10.3760/cma.j.issn.1673-4157.2016.02.007]
[9]殷俏,张云良,郭淑芹,等.视黄醇结合蛋白4、超敏C反应蛋白 与糖尿病视网膜病变的关系[J].国际内分泌代谢杂志,2016,36(03):149.[doi:10.3760/cma.j.issn.1673-4157.2016.03.02]
 Yin Qiao,Zhang Yunliang,Guo Shuqin,et al.Relationship of retinol binding protein 4 and high sensitive C-reactive protein with diabetic retinopathy[J].International Journal of Endocrinology and Metabolism,2016,36(01):149.[doi:10.3760/cma.j.issn.1673-4157.2016.03.02]
[10]王涛,张洁,祁范范,等.不同糖耐量人群血清25(OH)D3水平 及与胰岛β细胞功能的关系[J].国际内分泌代谢杂志,2016,36(04):226.[doi:10.3760/cma.j.issn.1673-4157.2016.04.04]
 Wang Tao*,Zhang Jie,Qi Fanfan,et al.Relationship between serum 25(OH)D3 level and islet β cell function in individuals with different glucose tolerance[J].International Journal of Endocrinology and Metabolism,2016,36(01):226.[doi:10.3760/cma.j.issn.1673-4157.2016.04.04]
[11]陈煜,曹萌,刘超.自噬在2型糖尿病中的作用[J].国际内分泌代谢杂志,2016,36(05):346.[doi:10.3760/cma.j.issn.1673-4157.2016.05.16]
 Chen Yu,Cao Meng,Liu Chao.Role of autophagy in type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2016,36(01):346.[doi:10.3760/cma.j.issn.1673-4157.2016.05.16]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81270861)通信作者:刘超,Email:liuchao@jsatcm.com
更新日期/Last Update: 2015-01-20