[1]李兴佳 曹萌 刘超.自噬与甲状腺癌的关系[J].国际内分泌代谢杂志,2015,(01):56-58.[doi:10.3760/cma.j.issn.1673-4157.2015.01.014]
 Li Xingjia,Cao Meng,Liu Chao..Relationship between autophagy and thyroid cancer[J].International Journal of Endocrinology and Metabolism,2015,(01):56-58.[doi:10.3760/cma.j.issn.1673-4157.2015.01.014]
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自噬与甲状腺癌的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年01
页码:
56-58
栏目:
综述
出版日期:
2015-01-20

文章信息/Info

Title:
Relationship between autophagy and thyroid cancer
作者:
李兴佳 曹萌 刘超
210028 南京,中国中医科学院江苏分院,南京中医药大学附属江苏省中西医结合医院内分泌代谢病院区
Author(s):
Li Xingjia Cao Meng Liu Chao.
Endocrine and Diabetes Center,Jiangsu Provine Hospital on Integration of Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Jiangsu Branch of China Academy of Chinese Medical Science, Nanjing 210028, ChinaCorresponding author:Liu Chao, Email:liuchao@nfmcn.com
关键词:
甲状腺癌 自噬 治疗
Keywords:
Thyroid cancer Autophagy Therapy
DOI:
10.3760/cma.j.issn.1673-4157.2015.01.014
摘要:
甲状腺癌是内分泌系统最常见的恶性肿瘤,尽管预后较好,但仍有部分甲状腺癌可能通过逃避细胞凋亡而抵抗放射和化学治疗。自噬作为细胞应对环境压力的一种机制,与多种疾病有着天然联系。基础水平的自噬能够维持细胞内稳态,因此自噬水平的改变能通过引起细胞稳态失调而导致一系列病理生理改变,直接或间接参与包括甲状腺癌在内的多种肿瘤的发生、发展。对于放射和化学治疗抵抗的甲状腺癌来说,自噬很有可能成为一个新的治疗靶点,因此研究自噬与甲状腺癌的关系,对于甲状腺癌的治疗有重要意义。
Abstract:
Thyroid cancer is the most common malignancy in endocrine system, although it has a good prognosis, some thyroid cancer may become resistant to radiotherapy and chemotherapy via apoptosis escaping. Autophagy, as a mechanism for cell response to environmental stress, has a natural link with various diseases. Cell homeostasis which is maintained by foundational autophagy may be broken by changes of autophagy level, and this will directly or indirectly participate in the pathogenesis and progression of multiple cancers including thyroid cancer.For those radiotherapy and chemotherapy resistance cancers, autophagy may become a new therapeutic target. Therefore, studying the relationship between autophagy and thyroid cancer is important for the treatment of thyroid cancer.

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备注/Memo

备注/Memo:
通信作者:刘超,Email:liuchao@nfmcn.com
更新日期/Last Update: 2015-01-20