[1]牛尚梅,韩卓笑,马慧娟.胆汁酸代谢与2型糖尿病[J].国际内分泌代谢杂志,2014,(03):191-193.[doi:10.3760/cma.j.issn.1673-4157.2014.03.013]
 Niu Shangmei*,Han Zhuoxiao,Ma Huijuan..Bile acid metabolism and type 2 diabetes[J].International Journal of Endocrinology and Metabolism,2014,(03):191-193.[doi:10.3760/cma.j.issn.1673-4157.2014.03.013]
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胆汁酸代谢与2型糖尿病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年03期
页码:
191-193
栏目:
综述(基础研究)
出版日期:
2014-06-30

文章信息/Info

Title:
Bile acid metabolism and type 2 diabetes
作者:
牛尚梅韩卓笑马慧娟
050017 石家庄,河北医科大学研究生学院(牛尚梅,韩卓笑),内科学教研室(马慧娟);050051 石家庄,河北省人民医院内分泌科(马慧娟)   
Author(s):
Niu Shangmei*Han ZhuoxiaoMa Huijuan.
*Graduate School of Hebei Medical University,Shijiazhuang 050051,China Corresponding author:Ma Huijuan,Email:huijuanma76@163.com
关键词:
胆汁酸2型糖尿病胆汁酸受体G蛋白耦联胆汁酸受体5
Keywords:
Bile acidsType 2 diabetes mellitusFarnesoid X receptorG protein-coupled bile acid receptor 5
DOI:
10.3760/cma.j.issn.1673-4157.2014.03.013
摘要:
研究发现,胆汁酸代谢异常影响胰岛素敏感性和糖代谢。胆汁酸是一种代谢调节器,它通过受体依赖性和非受体依赖性途径发挥信号分子的作用。在受体依赖性途径中,介导胆汁酸信号转导的最重要信号分子是核受体法尼醇X受体(FXR)及膜受体G蛋白耦联胆汁酸受体5(TGR5)。胆汁酸的信号通路紊乱会导致胰岛素敏感性降低。因此,对胆汁酸代谢的调节,尤其是对其信号通路的调节有望成为治疗2型糖尿病的潜在方法。
Abstract:
Studies show that dysregulation of bile acids could affect insulin sensitivity and glucose metabolism. Bile acids are metabolic regulators that act as signaling molecules through receptor-dependent and -independent pathways. The most prominent signaling molecules mediating bile acid signaling are the nuclear receptor farnesoid X receptor(FXR) and the membrane receptor G protein-coupled bile acid receptor 5(TGR5). Dysregulation of these pathways might contribute to the reduction of insulin sensitivity.Therefore,the manipulation of bile acid homeostasis,especially the regulation of its signaling pathways might be a potential treatment of type 2 diabetes.

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备注/Memo

备注/Memo:
通信作者:马慧娟,Email:huijuanma76@163.com
更新日期/Last Update: 2014-05-20