[1]袁和菊 刘晶 李娜 刘晓霞 李兴.Vaspin对2型糖尿病大血管病变的保护作用[J].国际内分泌代谢杂志,2019,39(04):261-264.[doi:10.3760/cma.j.issn.1673-4157.2019.04.011]
 Yuan Heju,Liu Jing,Li Na,et al.Protective effect of vaspin on macrovascular disease in type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2019,39(04):261-264.[doi:10.3760/cma.j.issn.1673-4157.2019.04.011]
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Vaspin对2型糖尿病大血管病变的保护作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年04期
页码:
261-264
栏目:
综述
出版日期:
2019-07-20

文章信息/Info

Title:
Protective effect of vaspin on macrovascular disease in type 2 diabetes mellitus
作者:
袁和菊1 刘晶2 李娜2 刘晓霞2 李兴2
1山西医科大学,太原 030001; 2山西医科大学第二医院内分泌科,太原 030009
Author(s):
Yuan Heju1 Liu Jing2 Li Na2 Liu Xiaoxia2 Li Xing2
1Shanxi Medical University, Taiyuan 030001, China; 2Department of Endocrinology, The Second Hospital of Shanxi Medical University, Taiyuan 030009, China
关键词:
Vaspin 2型糖尿病 大血管病变 动脉粥样硬化
Keywords:
Vaspin Type 2 diabetes mellitus Macrovascular diseases Atherosclerosis
DOI:
10.3760/cma.j.issn.1673-4157.2019.04.011
摘要:
2型糖尿病患者大血管并发症的患病风险是非糖尿病患者的2~4倍,其病理基础为动脉粥样硬化。动脉粥样硬化的易患因素如肥胖、高血压、血脂异常等在糖尿病(主要是2型糖尿病)人群中的发生率均明显增高,导致糖尿病患者动脉粥样硬化的患病率较高,发病更早、病情进展较快。内脏脂肪组织丝氨酸蛋白酶抑制剂(vaspin),是脂肪组织分泌的一种生物活性介质。Vaspin可通过改善动脉血管内皮细胞、平滑肌细胞、巨噬细胞的功能及血管炎性状态,发挥抗动脉粥样硬化作用,进而对2型糖尿病大血管病变起保护作用。
Abstract:
Compared with non-diabetic patients,patients with type 2 diabetes mellitus have two to four times increased risk of macrovascular diseases whose pathological basis is atherosclerosis. Risk factors of atherosclerosis such as obesity, hypertension and dyslipidemia were significantly increased in the population of diabetes mellitus(mainly type 2 diabetes mellitus), resulting in a higher prevalence of atherosclerosis, earlier onset and faster disease progression in the population of diabetes mellitus. Visceral adipose tissue-derived serine protease inhibitor(vaspin), is one of the bioactive mediators released by adipose tissue. Vaspin plays an anti-atherosclerosis role through the improvement of the function of arterial endothelial cells, smooth muscle cells and macrophages as well as the vascular inflammatory state, thus plays a protective role in macroangiopathy of type 2 diabetes mellitus.

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备注/Memo

备注/Memo:
通信作者:李兴,Email:13503504180@163.com
Corresponding author: Li Xing, Email:13503504180@163.com
基金项目:山西省国际科技合作项目(2015081031); 山西省卫生计生委科研项目(2014040)
Fund program:Shanxi International Science and Technology Cooperation Project(2015081031); Scientific Research Project of Shanxi Health and Family Planning Commission(2014040)
更新日期/Last Update: 2019-11-29