[1]陈蕊华 蒋晓真.维生素D与2型糖尿病患者的认知功能障碍研究进展[J].国际内分泌代谢杂志,2019,39(04):265-268.[doi:10.3760/cma.j.issn.1673-4157.2019.04.012]
 Chen Ruihua,Jiang Xiaozhen.Research progress of relationship between vitamin D and cognitive impairment in type 2 diabetic patients[J].International Journal of Endocrinology and Metabolism,2019,39(04):265-268.[doi:10.3760/cma.j.issn.1673-4157.2019.04.012]
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维生素D与2型糖尿病患者的认知功能障碍研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年04期
页码:
265-268
栏目:
综述
出版日期:
2019-07-20

文章信息/Info

Title:
Research progress of relationship between vitamin D and cognitive impairment in type 2 diabetic patients
作者:
陈蕊华 蒋晓真
上海市浦东新区人民医院内分泌科 201299
Author(s):
Chen Ruihua Jiang Xiaozhen
Department of Endocrinology, Pudong New Area People's Hospital, Shanghai 201299, China
关键词:
维生素D 2型糖尿病 认知功能减退
Keywords:
Vitamin D Type 2 diabetes mellitus Cognitive impairment
DOI:
10.3760/cma.j.issn.1673-4157.2019.04.012
摘要:
维生素D缺乏和糖尿病均是发生认知功能障碍的危险因素,二者并存可能更容易导致认知功能障碍。糖尿病患者中早期的轻度认知障碍目前仍未受到足够的重视。维生素D主要可通过促进神经营养因子合成、保护多巴胺神经元、抗氧化应激、清除脑内β淀粉样蛋白等多种机制来发挥神经保护和调节作用。在糖尿病患者中进行早期的认知功能评定、维生素D营养状态评估以及及时适当补充维生素D具有重要意义。
Abstract:
Vitamin D deficiency and diabetes are both risk factors for cognitive dysfunction, and the coexistence status may be more likely to lead to cognitive deficits. Yet, mild cognitive impairment at early stage in diabetic patients has not received enough attention. Vitamin D can play a neuroprotective and regulatory role by various actions such as promotion of the synthesis of neurotrophic agents, protection of dopamine neurons, antioxidant and anti-inflammatory effects, and clearance of β amyloid in the brain. It is important to identify the importance of early cognitive function assessment, vitamin D nutritional status assessment, and timely and appropriate supplementation of vitamin D in patients with diabetes.

参考文献/References:

[1] Holick MF.Vitamin D deficiency[J].N Engl J Med,2007,357(3):266-281.DOI:10.1056/NEJMra070553.
[2] Wang L,Gao P,Zhang M,et al.Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013[J].JAMA,2017,317(24):2515-2523.DOI:10.1001/jama.2017.7596.
[3] Moon JH,Lim S,Han JW,et al.Serum 25-hydroxyvitamin D level and the risk of mild cognitive impairment and dementia: the Korean Longitudinal Study on Health and Aging(KLoSHA)[J].Clin Endocrinol(Oxf),2015,83(1):36-42.DOI:10.1111/cen.12733.
[4] Wei R,Christakos S.Mechanisms underlying the regulation of innate and adaptive immunity by vitamin D[J].Nutrients,2015,7(10):8251-8260.DOI:10.3390/nu7105392.
[5] Lowry MB,Guo C,Borregaard N,et al.Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells[J].J Steroid Biochem Mol Biol,2014,143:183-191.DOI:10.1016/j.jsbmb.2014.02.004.
[6] Càndido FG,Bressan J.Vitamin D:link between osteoporosis, obesity, and diabetes?[J].Int J Mol Sci,2014,15(4):6569-6591.DOI:10.3390/ijms15046569.
[7] Harinarayan CV.Vitamin D and diabetes mellitus[J].Hormones(Athens),2014,13(2):163-181. DOI:10.1007/BF03401332.
[8] Zittermann A,Iodice S,Pilz S,et al.Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies[J].Am J Clin Nutr,2012,95(1):91-100.DOI:10.3945/ajcn.111.014779.
[9] Chowdhury R,Kunutsor S,Vitezova A,et al.Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies[J].BMJ,2014,348:g1903.DOI:10.1136/bmj.g1903.
[10] Calderón-Garcidueñas L,Franco-Lira M,D'Angiulli A,et al. Mexico city normal weight children exposed to high concentrations of ambient PM2.5 show high blood leptin and endothelin-1, vitamin D deficiency, and food reward hormone dysregulation versus low pollution controls. Relevance for obesity and Alzheimer disease[J].Environ Res,2015,140:579-592.DOI:10.1016/j.envres.2015.05.012.
[11] Bahrami A,Sadeghnia HR,Tabatabaeizadeh SA,et al.Genetic and epigenetic factors influencing vitamin D status[J].J Cell Physiol,2018,233(5):4033-4043.DOI:10.1002/jcp.26216.
[12] Hu Y,Chen J,Wang R,et al.Vitamin D nutritional status and its related factors for Chinese children and adolescents in 2010-2012[J].Nutrients,2017,9(9):pii:E1024.DOI:10.3390/nu9091024.
[13] Cheng Q,Du Y,Hong W,et al.Factors associated to serum 25-hydroxyvitamin D levels among older adult populations in urban and suburban communities in Shanghai, China[J].BMC Geriatr,2017,17(1):246.DOI:10.1186/s12877-017-0632-z.
[14] Wang L,Song Y,Manson JE,et al.Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies[J].Circ Cardiovasc Qual Outcomes,2012,5(6):819-829.DOI:10.1161/CIRCOUTCOMES.112.967604.
[15] Forouhi NG,Ye Z,Rickard AP,et al.Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer(EPIC)-Norfolk cohort and updated meta-analysis of prospective studies[J].Diabetologia,2012,55(8):2173-2182.DOI:10.1007/s00125-012-2544-y.
[16] Rafiq S,Jeppesen PB. Body mass index, vitamin D,and type 2 diabetes:a systematic review and meta-analysis[J].Nutrients,2018,10(9):pii:E1182.DOI:10.3390/nu10091182.
[17] He S,Yu S,Zhou Z,et al.Effect of vitamin D supplementation on fasting plasma glucose, insulin resistance and prevention of type 2 diabetes mellitus in non-diabetics: a systematic review and meta-analysis[J].Biomed Rep,2018,8(5):475-484.DOI:10.3892/br.2018.1074.
[18] Norman AW. Minireview: vitamin D receptor: new assignments for an already busy receptor[J].Endocrinology,2006,147(12):5542-5548.DOI:10.1210/en.2006-0946.
[19] Lips P,Eekhoff M,van Schoor N,et al.Vitamin D and type 2 diabetes[J].J Steroid Biochem Mol Biol,2017,173:280-285.DOI:10.1016/j.jsbmb.2016.11.021.
[20] Berridge MJ.Vitamin D deficiency and diabetes[J].Biochem J,2017,474(8):1321-1332.DOI:10.1042/BCJ20170042.
[21] Tsiaras WG,Weinstock MA.Factors influencing vitamin D status[J].Acta Derm Venereol,2011,91(2):115-124.DOI:10.2340/00015555-0980.
[22] Biessels GJ,Staekenborg S,Brunner E,et al.Risk of dementia in diabetes mellitus: a systematic review[J].Lancet Neurol,2006,5(1):64-74. DOI:10.1016/S1474-4422(05)70284-2.
[23] Simó R,Ciudin A,Simó-Servat O,et al.Cognitive impairment and dementia: a new emerging complication of type 2 diabetes-the diabetologist's perspective[J].Acta Diabetol,2017,54(5):417-424.DOI:10.1007/s00592-017-0970-5.
[24] Miller JW,Harvey DJ,Beckett LA,et al.Vitamin D status and rates of cognitive decline in a multiethnic cohort of older adults[J].JAMA Neurol,2015,72(11):1295-1303.DOI:10.1001/jamaneurol.2015.2115.
[25] Olsson E,Byberg L,Karlström B,et al.Vitamin D is not associated with incident dementia or cognitive impairment: an 18-y follow-up study in community-living old men[J].Am J Clin Nutr,2017,105(4):936-943.DOI:10.3945/ajcn.116.141531.
[26] Annweiler C,Dursun E,Féron F,et al.Vitamin D and cognition in older adults: international consensus guidelines[J].Geriatr Psychol Neuropsychiatr Vieil,2016,14(3):265-273.DOI:10.1684/pnv.2016.0613.
[27] Annweiler C.Vitamin D in dementia prevention[J].Ann N Y Acad Sci,2016,1367(1):57-63.DOI:10.1111/nyas.13058.
[28] Chen RH,Zhao XH,Gu Z,et al.Serum levels of 25-hydroxyvitamin D are associated with cognitive impairment in type 2 diabetic adults[J].Endocrine,2014,45(2):319-324.DOI:10.1007/s12020-013-0041-9.
[29] Alrefaie Z,Alhayani A.Vitamin D improves decline in cognitive function and cholinergic transmission in prefrontal cortex of streptozotocin-induced diabetic rats[J].Behav Brain Res,2015,287:156-162.DOI:10.1016/j.bbr.2015.03.050.
[30] Moghadamnia AA, Hakiminia S, Baradaran M,et al. Vitamin D improves learning and memory impairment in streptozotocin-induced diabetic mice[J].Arch Iran Med,2015,18(6):362-366.DOI:015186/AIM.007.
[31] Goodwill AM,Szoeke C.A systematic review and meta-analysis of the effect of low vitamin D on cognition[J].J Am Geriatr Soc,2017,65(10):2161-2168.DOI:10.1111/jgs.15012.

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备注/Memo

备注/Memo:
通信作者:蒋晓真,Email:jiangxz3338@126.com
Corresponding author: Jiang Xiaozhen, Email: jiangxz3338@126.com
基金项目:上海市浦东新区卫计委卫生科技项目(PW2016-22)
Fund program:Shanghai Pudong New Area Health Bureau Science and Technology Project(PW2016-22)
更新日期/Last Update: 2019-11-29