[1]俞冰鸿 杨菊红 单春艳.阻塞性睡眠呼吸暂停低通气综合征与糖尿病 视网膜病变的关系[J].国际内分泌代谢杂志,2019,39(04):269-271286.[doi:10.3760/cma.j.issn.1673-4157.2019.04.013]
 Yu Binghong,Yang Juhong,Shan Chunyan.Relationship between obstructive sleep apnea syndrome and diabetic retinopathy[J].International Journal of Endocrinology and Metabolism,2019,39(04):269-271286.[doi:10.3760/cma.j.issn.1673-4157.2019.04.013]
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阻塞性睡眠呼吸暂停低通气综合征与糖尿病 视网膜病变的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年04期
页码:
269-271286
栏目:
综述
出版日期:
2019-07-20

文章信息/Info

Title:
Relationship between obstructive sleep apnea syndrome and diabetic retinopathy
作者:
俞冰鸿 杨菊红 单春艳
天津医科大学代谢病医院糖尿病肾病科,国家卫生健康委员会激素与发育重点实验室(天津医科大学),天津市代谢性疾病重点实验室,天津医科大学代谢病医院内分泌研究所 300070
Author(s):
Yu Binghong Yang Juhong Shan Chunyan
Department of Diabetic Nephropathy, NHC Key Laboratory of Hormones and Development(Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, The Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China
关键词:
阻塞性睡眠呼吸暂停低通气综合征 2型糖尿病 糖尿病视网膜病变 低氧
Keywords:
Obstructive sleep apnea syndrome Type 2 diabetes mellitus Diabetic retinopathy Hypoxia
DOI:
10.3760/cma.j.issn.1673-4157.2019.04.013
摘要:
阻塞性睡眠呼吸暂停低通气综合征(OSAS)是一种累及多系统的睡眠呼吸障碍性疾病,其与胰岛素抵抗、2型糖尿病(T2DM)密切相关。近年来,越来越多的证据支持OSAS及低氧与糖尿病视网膜病变(DR)相关。无论是横断面研究还是前瞻性队列研究均显示,OSAS是DR的独立危险因素。关于OSAS严重程度与DR不同分期之间的研究相对较少且结果不一。二者相关的潜在机制可能为氧化应激、炎性反应、血流动力学异常、肾素-血管紧张素系统激活。对于伴有OSAS的T2DM患者,早期诊治OSAS,解除低氧,可能对延缓DR的发生和进展起一定作用。
Abstract:
Obstructive sleep apnea syndrome(OSAS), a sleep disordered breathing, impairs multiple systems, which also associated with insulin resistance, type 2 diabetes mellitus(T2DM). Recently, more and more evidences supported that OSAS and hypoxia are closely related to diabetic retinopathy(DR). Both cross-sectional and prospective studies indicated that OSAS was the independent risk factor of DR. Studies on the relationship between severity of OSAS and different stages of DR are rare and have different results. The mechanisms may related to oxidative stress, inflammatory response, hemodynamic abnormality and activation of renin-angiotensin system. For T2DM patients with OSAS, early diagnosis and treatment of OSAS and relief of hypoxia may play a significant role in delaying the occurrence and progression of DR.

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备注/Memo

备注/Memo:
通信作者:单春艳,Email:chunyanshan@hotmail.com
Corresponding author: Shan Chunyan,Email:chunyanshan@hotmail.com
基金项目:国家自然科学基金青年科学基金(81700631); 天津市科技计划项目(17ZXHLSY00040)
Fund program:National Natural Science Foundation for Young Scientists of China(81700631); Science and Technology Project in Tianjin(17ZXHLSY00040).
更新日期/Last Update: 2019-11-29