参考文献/References:
[1] Louro TM,Matafome PN,Nunes EC,et al.Insulin and metformin may prevent renal injury in young type 2 diabetic Goto-Kakizaki rats[J].Eur J Pharmacol,2011,653(1-3):89-94.DOI:10.1016/j.ejphar.2010.11.029.
[2] Maheshwari RA,Balaraman R,Sen AK,et al.Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats[J].Indian J Pharmacol,2014,46(6):627-632.DOI:10.4103/0253-7613.144924.
[3] Agrawal NK,Kant S.Targeting inflammation in diabetes: newer therapeutic options[J].World J Diabetes,2014,5(5):697-710.DOI:10.4239/wjd.v5.i5.697.
[4] Yi B,Hu X,Zhang H,et al.Nuclear NF-κB p65 in peripheral blood mononuclear cells correlates with urinary MCP-1, RANTES and the severity of type 2 diabetic nephropathy[J].PLoS One,2014,9(6):e99633.DOI:10.1371/journal.pone.0099633.
[5] 陈频,陈晶波,陈文钰,等.槲皮素对糖尿病大鼠肾脏泛素蛋白酶系统介导核因子-κB p65表达的影响[J]. 中华内科杂志,2012,51(6):460-465. DOI:10.3760/cma.j.issn.0578-1426.2012.06.015
[6] Gu J,Ye S,Wang S,et al.Metformin inhibits nuclear factor-κB activation and inflammatory cytokines expression induced by high glucose via adenosine monophosphate-activated protein kinase activation in rat glomerular mesangial cells in vitro[J].Chin Med J(Engl),2014,127(9):1755-1760.
[7] Chung CH,Fan J,Lee EY,et al.Effects of tumor necrosis factor-α on podocyte expression of monocyte chemoattractant protein-1 and in diabetic nephropathy[J].Nephron Extra,2015,5(1):1-18. DOI:10.1159/000369576.
[8] Hattori Y,Suzuki K,Hattori S,et al.Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells[J].Hypertension,2006,47(6):1183-1188. DOI:10.1161/01.HYP.0000221429.94591.72.
[9] Xie S,Lu K,Zhang Y,et al.Effects of Jiangya Xiaoke prescription on TGF-β1 in diabetic nephropathy rats with hypertension and its mechanisms[J].Int J Clin Exp Med,2015,8(4):5129-5136.
[10] Kim J,Kwak HJ,Cha JY,et al.Metformin suppresses lipopolysaccharide(LPS)-induced inflammatory response in murine macrophages via activating transcription factor-3(ATF-3)induction[J].J Biol Chem,2014,289(33):23246-23255.DOI:10.1074/jbc.M114.577908.
[11] Kim J,Shon E,Kim CS,et al. Renal podocyte injury in a rat model of type 2 diabetes is prevented by metformin[J].Exp Diabetes Res,2012,2012:210821.DOI:10.1155/2012/210821.
[12] Piwkowska A,Rogacka D,Jankowski M,et al.Metformin induces suppression of NAD(P)H oxidase activity in podocytes[J].Biochem Biophys Res Commun,2010,393(2):268-273.DOI:10.1016/j.bbrc.2010.01.119.
[13] Budak ,abuzek K,Budak RJ,et al. Metformin reduces the expression of NADPH oxidase and increases the expression of antioxidative enzymes in human monocytes/macrophages cultured in vitro[J].Exp Ther Med,2016,11(3):1095-1103.DOI:10.3892/etm.2016.2977.
[14] Kelly B,Tannahill GM,Murphy MP,et al.Metformin inhibits the production of reactive oxygen species from NADH:ubiquinone oxidoreductase to limit induction of interleukin-1β(IL-1β)and boosts interleukin-10(IL-10)in lipopolysaccharide(LPS)-activated macrophages[J].J Biol Chem,2015,290(33):20348-20359.DOI:10.1074/jbc.M115.662114.
[15] Viollet B,Guigas B,Sanz Garcia N,et al.Cellular and molecular mechanisms of metformin: an overview[J].Clin Sci(Lond),2012,122(6):253-270.DOI:10.1042/CS20110386.
[16] Takiyama Y,Harumi T,Watanabe J,et al.Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism[J].Diabetes,2011,60(3):981-992.DOI:10.2337/db10-0655.
[17] Takiyama Y,Haneda M.Hypoxia in diabetic kidneys[J].Biomed Res Int,2014,2014:837421.DOI:10.1155/2014/837421.
[18] Kuan CJ,al-Douahji M,Shankland SJ.The cyclin kinase inhibitor p21WAF1, CIP1 is increased in experimental diabetic nephropathy:potential role in glomerular hypertrophy[J].J Am Soc Nephrol,1998,9(6):986-993.
[19] Molnar Z,Millward AB,Tse W,et al.p21(WAF1/CIP1)expression is differentially regulated by metformin and rapamycin[J].Int J Chronic Dis,2014,2014:327640.DOI:10.1155/2014/327640.
[20] 赵鸿,冀倩倩,李永霞,等.mTOR 复合物在糖尿病肾病小鼠肾组织中的不同分布和表达[J]. 解剖学报,2014,45(4):555-560.DOI:10.3969/j.issn.0529-1356.2014.04.021.
[21] 罗霞,邓玲艳,许文娟,等.腺苷酸活化蛋白激酶通过抑制mTOR信号通路缓解糖尿病大鼠肾脏细胞外基质沉积[J].华中科技大学学报(医学版),2015,44(1):10-15.DOI:10.3870/j.issn.1672-0741.2015.01.002.
[22] Langer S,Kreutz R,Eisenreich A.Metformin modulates apoptosis and cell signaling of human podocytes under high glucose conditions[J].J Nephrol,2016,29(6):765-773.DOI:10.1007/s40620-015-0258-1.
[23] Wang XX,Jiang T,Shen Y,et al.The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria[J].Am J Physiol Renal Physiol,2009,297(6):F1587-F1596. DOI:10.1152/ajprenal.00404.2009.
[24] Zhang C,Shao M,Yang H,et al.Attenuation of hyperlipidemia- and diabetes-induced early-stage apoptosis and late-stage renal dysfunction via administration of fibroblast growth factor-21 is associated with suppression of renal inflammation[J].PLoS One,2013,8(12):e82275.DOI:10.1371/journal.pone.0082275.
[25] 王小英,冯积容,周艳,等. 2型糖尿病早期肾病大鼠模型制备及二甲双胍干预作用[J]. 临床医学工程,2013, 20(2):152-155.DOI:10.3969/j.issn.1674-4659.2013.02.0152.
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