[1]王登,贾正平,李茂星,等.糖皮质激素与2型糖尿病[J].国际内分泌代谢杂志,2014,(02):118-122.[doi:10.3760/cma.j.issn.1673-4157.2014.02.014]
 Wang Deng*,Jia Zhengping,Li Maoxing,et al.Glucocorticoid and type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2014,(02):118-122.[doi:10.3760/cma.j.issn.1673-4157.2014.02.014]
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糖皮质激素与2型糖尿病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年02期
页码:
118-122
栏目:
综述
出版日期:
2014-04-30

文章信息/Info

Title:
Glucocorticoid and type 2 diabetes mellitus
作者:
王登贾正平李茂星周珺张汝学
730000 兰州,甘肃中医学院(王登,张汝学);730050 兰州军区总医院高原环境损伤防治重点实验室,国家中医药管理局临床中药学重点学科(王登,贾正平,李茂星,周珺,张汝学)   
Author(s):
Wang Deng*Jia ZhengpingLi MaoxingZhou JunZhang Ruxue.
*Gansu University of Traditional Chinese Medicine, Lanzhou 730000,China Corresponding author:Zhang Ruxue,Email:ruxuezh@hotmail.com
关键词:
糖皮质激素2型糖尿病β细胞胰岛素抵抗
Keywords:
GlucocorticoidType 2 diabetes mellitusβ cellInsulin resistance
DOI:
10.3760/cma.j.issn.1673-4157.2014.02.014
摘要:
糖皮质激素与2型糖尿病的发生、发展密切相关,但其诱导2型糖尿病发生的具体机制尚不明确。研究认为,糖皮质激素可能通过对胰岛β细胞增殖和发育、分泌功能的作用,以及对胰岛素信号转导通路、糖、脂代谢、葡萄糖转运和吸收等方面的影响,参与2型糖尿病的发生。11β-羟类固醇脱氢酶、糖皮质激素受体、热休克蛋白等通过影响糖皮质激素的作用,成为治疗2型糖尿病的新靶点。
Abstract:
Glucocorticoid is closely related to the occurrence of type 2 diabetes,but the exact mechanism is not very clear. Studies show that through affecting the proliferation, development,secretion of islet β cell,influencing insulin signaling pathway,glucose and lipid metabolism,glucose transportation and absorption,glucocorticoid may be involved in the development of type 2 diabetes.11 beta hydroxy steroid dehydrogenase,glucocorticoid receptors,heat shock protein and so on,become novel targets for the treatment of type 2 diabetes by modulating the effects of glucocorticoid.

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备注/Memo

备注/Memo:
通信作者:张汝学,Email:ruxuezh@hotmail.com
更新日期/Last Update: 2014-03-20