[1]赵金,牛晨晓,覃文萱,等.2型糖尿病患者血清NETs水平与左室舒张功能的相关性研究[J].国际内分泌代谢杂志,2024,44(03):183-188.[doi:10.3760/cma.j.cn121383-20231029-10051]
 Zhao Jin,Niu Chenxiao,Qin Wenxuan,et al.Correlation between serum NETs level and left ventricular diastolic function in type 2 diabetic patients[J].International Journal of Endocrinology and Metabolism,2024,44(03):183-188.[doi:10.3760/cma.j.cn121383-20231029-10051]
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2型糖尿病患者血清NETs水平与左室舒张功能的相关性研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
44
期数:
2024年03期
页码:
183-188
栏目:
论著
出版日期:
2024-05-20

文章信息/Info

Title:
Correlation between serum NETs level and left ventricular diastolic function in type 2 diabetic patients
作者:
赵金牛晨晓覃文萱向光大
武汉科技大学医学部医学院、中部战区总医院内分泌科,武汉 430070
Author(s):
Zhao Jin Niu Chenxiao Qin Wenxuan Xiang Guangda.
Medical College, Wuhan University of Science and Technology, Department of Endocrinology, Central Theater General Hospital, Wuhan 430070 China
关键词:
血清NETs水平 2型糖尿病 左室舒张功能
Keywords:
Serum NETs level Type 2 diabetes mellitus Left ventricular diastolic function
DOI:
10.3760/cma.j.cn121383-20231029-10051
摘要:
目的 探讨2型糖尿病(T2DM)患者血清中性粒细胞胞外诱捕网(NETs)水平与左室舒张功能的关系。方法 选取2022年10月至2023年5月初诊断T2DM患者107例为病例组,根据超声心动图检测分为T2DM无左室舒张功能减退组(A组)和T2DM合并左室舒张功能减退组(B组),和同期随机选择年龄性别匹配的糖耐量正常人群50例作为对照组,检测其血清指标及超声心动图参数并进行比较分析。结果 B组NETs水平明显高于对照组及A组(P<0.05); 在T2DM组中,NETs水平与左室舒张功能呈负相关,在校正了相关混杂因素后,NETs为影响E/A值的独立危险因素。NETs诊断T2DM合并左室舒张功能减退的最佳切点值为NETs=34.11 ng/ml,其诊断灵敏度为0.59,特异度为0.58。结论 T2DM患者NETs水平与左室舒张功能呈负相关,是T2DM患者左室舒张功能减退的独立危险因素,对T2DM合并左室舒张功能减退有一定的诊断效能。
Abstract:
Objective To investigate the relationship between serum NETs levels and left ventricular diastolic function in patients with T2DM(type 2 diabetes mellitus)patients.Methods A total of 107 T2DM patients from October 2022 to May 2023 were selected as the case group, and were divided into T2DM without left ventricular diastolic dysfunction group(group A)and T2DM combined with left ventricular diastolic dysfunction group(group B)according to echocardiography, and 50 patients with age-gender matched normal glucose tolerance were randomly selected as the control group.The serum indexes and echocardiogram parameters were detected and compared.Results The levels of NETs in group B were significantly higher than control group and group A(P<0.05). In the T2DM group, the level of NETs was negatively correlated with left ventricular diastolic function, after adjusting for confounding factors, NETs were independent risk factors affecting E/A values. The optimal tangential value of NETs in the diagnosis of T2DM with left ventricular diastolic dysfunction was NETs=34.11 ng/mL, the diagnostic sensitivity was 0.59, and the specificity was 0.58.Conclusion The level of NETs in T2DM patients is negatively correlated with left ventricular diastolic function, which is an independent risk factor for left ventricular diastolic dysfunction in T2DM patients, and has certain diagnostic efficacy for T2DM patients with left ventricular diastolic dysfunction.

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备注/Memo

备注/Memo:
通信作者:向光大,Email:Guangda64@hotmail.com
基金项目:国家自然科学基金项目(81870573,81570730)
更新日期/Last Update: 2024-05-30