[1]王佳蓓 陈风 刘莹 王涤非.Nur77与物质能量代谢的关系[J].国际内分泌代谢杂志,2019,39(01):49-52.[doi:10.3760/cma.j.issn.1673-4157.2019.01.012]
　Wang Jiabei,Chen Feng,Liu Ying,et al.Relationship between Nur77 and meterial, energy metabolism[J].International Journal of Endocrinology and Metabolism,2019,39(01):49-52.[doi:10.3760/cma.j.issn.1673-4157.2019.01.012]
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Nur77与物质能量代谢的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年01期
页码:
49-52
栏目:
综述
出版日期:
2019-01-20

文章信息/Info

Title:
Relationship between Nur77 and meterial, energy metabolism
作者:
王佳蓓1 陈风1 刘莹2 王涤非1
1中国医科大学附属第一医院老年医学内分泌科,沈阳 110001; 2中国医科大学,沈阳 110013
Author(s):
Wang Jiabei1;  Chen Feng1;  Liu Ying2;  Wang Difei1
1Department of Geriatrics, The First Hospital of Shenyang, Shengyang 110001, China; 2China Medical University, Shenyang 110013, China
关键词:
Nur77;  葡萄糖代谢;  脂代谢;  能量代谢;  代谢性疾病
Keywords:
Nur77;  Glucose metabolism;  Lipid metabolism;  Energy metabolism;  Metabolic diseases
DOI:
10.3760/cma.j.issn.1673-4157.2019.01.012
摘要:
Nur77是孤儿核受体,也是由配体激活的转录因子,其表达可激活或者抑制下游基因转录。Nur77能够调控糖原合成,是激素调控下游代谢基因途径中不可或缺的中间环节; 也可能与脂肪细胞分化中一些相关基因存在交叉反应,从而在脂肪细胞分化中产生重要作用; 还是机体维持能量平衡的重要调控因子。Nur77可调节糖代谢、脂代谢、能量代谢甚至与代谢性疾病密切相关。因此,许多可激动Nur77的合成或天然化学物质可能是未来治疗代谢性疾病的潜在药物。
Abstract:
Nur77 is an orphan nuclear receptor and a ligand-activated transcription factor whose expression activates or inhibits downstream gene transcription. Nur77, which can regulate glycogen synthesis, is an indispensable intermediate link in hormone regulation of downstream metabolic gene pathway. There may also be cross-reactions with some genes related to adipocyte differentiation, which may play important roles in adipocyte differentiation, and are also important regulatory factors for maintaining energy balance in the body. Nur77 regulates glucose metabolism,lipid metabolism, energy metabolism and even metabolic diseases. Therefore, many exciting synthetic or natural chemicals of Nur77 may be potential drugs for the treatment of metabolic diseases in the future.

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备注/Memo

备注/Memo:
通信作者:王涤非,Email:wdf8lm@qq.com
基金项目:国家自然科学基金(31570819); 辽宁省科技计划项目(2015225024); 中央支持地方科技引导项目(2016007024)
Corresponding author: Wang Difei, Email:wdf8lm@qq.com
Fund program:National Natural Science Foundation of China(31570819); Liaoning Science and Technology Plan Project(2015225024); The Central Government Supports Local Science and Technology Guidance Projects(2016007024)
更新日期/Last Update: 2019-01-20