[1]叶勇健 潘天荣.GLP-1受体激动剂在肥胖相关性肾病中的作用机制[J].国际内分泌代谢杂志,2019,39(01):45-48.[doi:10.3760/cma.j.issn.1673-4157.2019.01.011]
 Ye Yongjian,Pan Tianrong.Mechanisms of GLP-1 receptor agonist in obesity-related glomerulopathy[J].International Journal of Endocrinology and Metabolism,2019,39(01):45-48.[doi:10.3760/cma.j.issn.1673-4157.2019.01.011]
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GLP-1受体激动剂在肥胖相关性肾病中的作用机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年01期
页码:
45-48
栏目:
综述
出版日期:
2019-01-20

文章信息/Info

Title:
Mechanisms of GLP-1 receptor agonist in obesity-related glomerulopathy
作者:
叶勇健 潘天荣
安徽医科大学第二附属医院内分泌科,合肥 230601
Author(s):
Ye Yongjian Pan Tianrong
Department of Endocrinology, The Second Affilliated Hospital of Anhui Medical University, Hefei 230601, China
关键词:
肥胖相关性肾病 胰高血糖素样肽-1 肾脏疾病
Keywords:
Obesity-related glomerulopathy Glucagon-like peptide-1 Kidney disease
DOI:
10.3760/cma.j.issn.1673-4157.2019.01.011
摘要:
肥胖相关性肾病(ORG)是一种由于肥胖及代谢综合征引起的胰岛素抵抗和慢性炎性反应而最终导致的肾脏损害。其发生机制比较复杂,可能与肾小球血流动力异常、炎性反应、氧化应激以及胰岛素抵抗等有关。近年来研究提示,胰高血糖素样肽-1受体激动剂对ORG有一定的保护作用。
Abstract:
Obesity-related glomerulopathy(ORG)is a renal lesion caused by insulin resistance and chronic inflammation caused by obesity and metabolic syndrome. The mechanisms are complex, especially glomerulus hemodynamic changes, inflammatory reaction, oxidative stress, insulin resistance.Recently, a number of studies have reported that glucagon-like peptide-1 receptor agonists have a protective effect on ORG.

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备注/Memo

备注/Memo:

基金项目:安徽省科技厅公益性技术应用研究联动项目(1501ld04042); 安徽省高等学校自然科学研究重点项目(KJ2018A0202)通信作者:潘天荣,Email:ptr1968@163.com
Corresponding author: Pan Tianrong, Email:ptr1968@163.com
Fund program:Linkage Projects of the Public Welfare Technology Application Research of Anhui Provincial Science and Technology Department(1501ld04042); Key Projects of the Natural Science Research of Anhui Higher Education Institution(KJ2018A0202)
更新日期/Last Update: 2019-01-20