[1]韩秀丹 朱凌燕 徐积兄.二甲双胍对糖尿病视网膜病变的作用及机制[J].国际内分泌代谢杂志,2019,39(01):53-56.[doi:10.3760/cma.j.issn.1673-4157.2019.01.013]
 Han Xiudan,Zhu Lingyan,Xu Jixiong.Effects of metformin on diabetic retinopathy and its mechanism[J].International Journal of Endocrinology and Metabolism,2019,39(01):53-56.[doi:10.3760/cma.j.issn.1673-4157.2019.01.013]
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二甲双胍对糖尿病视网膜病变的作用及机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年01期
页码:
53-56
栏目:
综述
出版日期:
2019-01-20

文章信息/Info

Title:
Effects of metformin on diabetic retinopathy and its mechanism
作者:
韩秀丹 朱凌燕 徐积兄
南昌大学第一附属医院内分泌科 330006
Author(s):
Han Xiudan Zhu Lingyan Xu Jixiong
Department of Endocrinology, The First Affiliated Hospital of Nanchang University, Nanchang 330000, China
关键词:
二甲双胍 糖尿病视网膜病变
Keywords:
Metformin Diabetic Retinopathy
DOI:
10.3760/cma.j.issn.1673-4157.2019.01.013
摘要:
二甲双胍是国内、外推荐治疗2型糖尿病的首选一线用药,其具有良好的单药/联合治疗的疗效和安全性证据,但对糖尿病视网膜病变的作用仍然不明确。而且,至今仍缺少直接的临床证据证明二甲双胍对糖尿病视网膜病变的作用,甚至有人提出严重非增殖性和增殖性糖尿病视网膜病变是二甲双胍使用的禁忌证。近年来研究发现,二甲双胍可能通过减少视网膜损伤、减少视网膜静脉阻塞、减少视网膜新生血管形成、减轻视网膜炎性反应以及改善胰岛素抵抗等机制,延缓糖尿病视网膜病变的发生、发展,这为临床及科研人员提供了新的思路。
Abstract:
Metformin is the first-line drug recommended for the treatment of type 2 diabetes all over the world. It has good efficacy and safety evidence of single-agent/combination therapy, but the effect on diabetic retinopathy remains unclear. Moreover, there is still no direct clinical evidence to prove the effect of metformin on diabetic retinopathy. It has even been suggested that severe non-proliferative and proliferative diabetic retinopathy is a contraindication for the use of metformin. In recent years, studies showed that metformin could delay the occurrence and development of diabetic retinopathy by reducing retinal damage, reducing retinal vein occlusion, reducing retinal neovascularization, reducing retinal inflammatory response, and improving insulin resistance, thus may provide new ideas for clinical and scientific researchers.

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备注/Memo

备注/Memo:
通信作者:朱凌燕,Email:zly982387@126.com; 徐积兄,Email:xujixiong@163.com
基金项目:国家自然科学基金(81860153); 江西省自然科学基金(2016ZRMSB1355)
Corresponding author: Zhu Lingyan, Email:zly982387@126.com; Xu Jixiong, Email: xujixiong@163.com
Fund program:National Natural Science Foundation of China(81860153); Natural Science Foundation of Jiangxi Province of China(2016ZRMSB1355)
更新日期/Last Update: 2019-01-20