[1]顾子良 王洪东 朱大龙 毕艳.2型糖尿病治疗方法对肠道菌群的影响[J].国际内分泌代谢杂志,2018,38(04):254-256270.[doi:10.3760/cma.j.issn.1673-4157.2018.04.009]
 Gu Ziliang,Wang Hongdong,Zhu Dalong,et al.Effects of treatment of type 2 diabetes on gut microbiota[J].International Journal of Endocrinology and Metabolism,2018,38(04):254-256270.[doi:10.3760/cma.j.issn.1673-4157.2018.04.009]
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2型糖尿病治疗方法对肠道菌群的影响()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年04期
页码:
254-256270
栏目:
临床研究
出版日期:
2018-07-20

文章信息/Info

Title:
Effects of treatment of type 2 diabetes on gut microbiota
作者:
顾子良 王洪东 朱大龙 毕艳
210029 南京大学医学院附属鼓楼医院内分泌科
Author(s):
Gu Ziliang Wang Hongdong Zhu Dalong Bi Yan.
Department of Endocrinology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210029, China
关键词:
2型糖尿病 肠道菌群
Keywords:
Type 2 diabetes mellitus Gut microbiota
DOI:
10.3760/cma.j.issn.1673-4157.2018.04.009
摘要:
近年来越来越多的研究表明,肠道菌群与2型糖尿病密切相关,其在2型糖尿病的发生、发展过程中扮演了重要角色。饮食、运动、降糖药物、代谢手术等糖尿病治疗方法在降低血糖的同时均影响肠道菌群的结构和功能,而肠道菌群的变化可能是这些糖尿病治疗方法改善机体代谢紊乱的机制之一。
Abstract:
In recent years, more and more studies have shown that human gut microbiota was closely related to type 2 diabetes, which plays a pivotal role in the pathogenesis and development of type 2 diabetes. Treatment of type 2 diabetes such as diet, exercise, hypoglycemic drugs and metabolic surgery can influence the structure and function of gut microbiota while lowering blood glucose. The change of gut microbiota may be one of the mechanisms that treatment of type 2 diabetes improve the body's metabolic disorders.

参考文献/References:


[1] Burcelin R,Serino M,Chabo C,et al.Gut microbiota and diabetes: from pathogenesis to therapeutic perspective[J].Acta Diabetol,2011,48(4):257-273.DOI:10.1007/s00592-011-0333-6.
[2] Frank DN,St Amand AL,Feldman RA,et al.Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases[J].Proc Natl Acad Sci U S A,2007,104(34):13780-13785.DOI:10.1073/pnas.0706625104.
[3] Flintoft L.Disease genomics: associations go metagenome-wide[J].Nat Rev Genet,2012,13(11):756.DOI:10.1038/nrg3347.
[4] Voreades N,Kozil A,Weir TL.Diet and the development of the human intestinal microbiome[J].Front Microbiol,2014,5:494.DOI:10.3389/fmicb.2014.00494.
[5] Musso G,Gambino R,Cassader M.Obesity, diabetes, and gut microbiota: the hygiene hypothesis expanded [J].Diabetes Care,2010,33(10):2277-2284.DOI:10.2337/dc10-0556.
[6] Qin J,Li Y,Cai Z,et al.A metagenome-wide association study of gut microbiota in type 2 diabetes[J].Nature,2012,490(7418):55-60.DOI:10.1038/nature11450.
[7] Karlsson FH,Tremaroli V,Nookaew I,et al. Gut metagenome in European women with normal, impaired and diabetic glucose control[J].Nature,2013,498(7452):99-103.DOI:10.1038/nature12198.
[8] David LA, Maurice CF, Carmody RN,et al. Diet rapidly and reproducibly alters the human gut microbiome[J].Nature,2014,505(7484):559-563.DOI:10.1038/nature12820.
[9] Wu GD,Chen J,Hoffmann C,et al.Linking long-term dietary patterns with gut microbial enterotypes[J].Science,2011,334(6052):105-108.DOI:10.1126/science.1208344.
[10] 白钰,吕全胜,马晓丽.高膳食纤维低血糖生成指数饮食对2 型糖尿病患者肠道菌群和血糖的影响研究[J].中国全科医学,2016,19(20):2469-2472.DOI:10.3969/j.issn.1007-9572.2016.20.023.
[11] Yamaguchi Y,Adachi K,Sugiyama T,et al.Association of intestinal microbiota with metabolic markers and dietary habits in patients with type 2 diabetes[J].Digestion,2016,94(2):66-72. DOI:10.1159/000447690.
[12] Clarke SF,Murphy EF,O'Sullivan O,et al.Exercise and associated dietary extremes impact on gut microbial diversity[J].Gut,2014,63(12):1913-1920.DOI:10.1136/gutjnl-2013-306541.
[13] 乔德才,陈敬,赵立平.采用DNA指纹图谱技术分析中长跑运动员肠道菌群结构特征[J].中国运动医学杂志,2004,23(5):517-521. DOI:10.3969/j.issn.1000-6710.2004.05.011.
[14] Wu H,Esteve E,Tremaroli V,et al.Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug[J].Nat Med,2017,23(7):850-858.DOI:10.1038/nm.4345.
[15] Hamer HM,Jonkers D,Venema K,et al.Review article: the role of butyrate on colonic function[J].Aliment Pharmacol Ther,2008,27(2):104-119.DOI:10.1111/j.1365-2036.2007.03562.x.
[16] Delzenne NM,Cani PD,Neyrinck AM.Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data[J].J Nutr,2007,137(11 Suppl):2547S-2551S.
[17] 张秀英, 韩学尧, 陈颖丽, 等. 阿卡波糖对糖尿病前期患者肠道菌群的影响[J]. 中华糖尿病杂志, 2012,4(增刊):31-32.
[18] 肖党生,王招娣,杨云梅,等.糖尿病患者肠道菌群研究[J].中国微生物学杂志, 2006,18(4):275-276.DOI:10.3969/j.issn.1005-376X.2006.04.006.
[19] Su B,Liu H,Li J,et al.Acarbose treatment affects the serum levels of inflammatory cytokines and the gut content of bifidobacteria in Chinese patients with type 2 diabetes mellitus[J].J Diabetes,2015,7(5):729-739.DOI:10.1111/1753-0407.12232.
[20] 刘海霞,李晶,刘奔,等.阿卡波糖对 2 型糖尿病患者粪便中双歧杆菌数量的影响[J].中华内分泌代谢杂志,2011,27(11):47-50.DOI:10.3760/cma.j.issn.1000-6699.2011.11.015.
[21] 徐杰,苏本利,关玉峰,等.阿卡波糖对糖尿病患者肠道双歧杆菌的影响[J].中国医学创新,2013,(9): 37-38. DOI:10.3969/j.issn.1674-4985.2013.09.018.
[22] Weaver GA,Tangel CT,Krause JA,et al.Acarbose enhances human colonic butyrate production[J].J Nutr,1997,127(5):717-723. DOI:10.1093/jn/127.5.717.
[23] 吕庆国, 李益, 童南伟. 阿卡波糖对 2 型糖尿病患者体重的影响[J]. 中华内科杂志, 2013,52(12):1079-1081.DOI:10.3760/cma.j.issn.0578-1426.2013.12.024.
[24] Zhang H,DiBaise JK,Zuccolo A,et al.Human gut microbiota in obesity and after gastric bypass[J].Proc Natl Acad Sci U S A,2009,106(7):2365-2370.DOI:10.1073/pnas.0812600106.
[25] Furet JP,Kong LC,Tap J,et al.Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers[J].Diabetes,2010,59(12):3049-3057.DOI:10.2337/db10-0253.
[26] Kong LC,Tap J,Aron-Wisnewsky J,et al.Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue genes[J].Am J Clin Nutr,2013,98(1):16-24.DOI:10.3945/ajcn.113.058743.
[27] Graessler J,Qin Y,Zhong H,et al.Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters[J].Pharmacogenomics J,2013,13(6):514-522.DOI:10.1038/tpj.2012.43.
[28] Palleja A,Kashani A,Allin KH,et al.Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistentchanges of the individual gut microbiota[J].Genome Med,2016,8(1):67.DOI:10.1186/s13073-016-0312-1.
[29] Murphy R,Tsai P,Jüllig M,et al.Differential changes in gut microbiota after gastric bypass and sleeve gastrectomy bariatric surgery vary according to diabetes remission[J].Obes Surg,2017,27(4):917-925.DOI:10.1007/s11695-016-2399-2.

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备注/Memo

备注/Memo:
基金项目:江苏省重点研发专项(BE2016606)
通信作者:王洪东,Email:dong_fighting@163.com
更新日期/Last Update: 2018-04-30