[1]张雅楠,郗光霞,杨翠萍,等.自噬在非酒精性脂肪性肝病中的变化及作用[J].国际内分泌代谢杂志,2017,37(01):11-13.[doi:10.3760/cma.j.issn.1673-4157.2017.01.03]
　Zhang Yanan*,Xi Guangxia,Yang Cuiping,et al.The change and function of autophagy in nonalcoholic fatty liver disease[J].International Journal of Endocrinology and Metabolism,2017,37(01):11-13.[doi:10.3760/cma.j.issn.1673-4157.2017.01.03]
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自噬在非酒精性脂肪性肝病中的变化及作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年01期
页码:
11-13
栏目:
综述
出版日期:
2017-01-20

文章信息/Info

Title:
The change and function of autophagy in nonalcoholic fatty liver disease
作者:
张雅楠; 郗光霞; 杨翠萍; 冯瑜
030001 太原,山西医科大学(张雅楠,杨翠萍,冯瑜); 030032 太原,山西医科大学附属山西大医院内分泌科(郗光霞)
Author(s):
Zhang Yanan*;  Xi Guangxia;  Yang Cuiping;  Feng Yu.
*Shanxi Medical University, Taiyuan 030001, China
关键词:
自噬;  非酒精性脂肪性肝病;  哺乳动物雷帕霉素靶蛋白
Keywords:
Autophagy;  Nonalcoholic fatty liver disease;  Mammalian rapamycin target protein
DOI:
10.3760/cma.j.issn.1673-4157.2017.01.03
摘要:
自噬是一种溶酶体依赖性降解途径,已有大量研究报道,自噬参与了非酒精性脂肪性肝病(NAFLD)的发生及发展。在NAFLD早期,自噬增强,并可以通过抑制引起NAFLD的“二次打击”延缓NAFLD的进展。在NAFLD晚期,由于自噬相关基因(Atg)7降解、哺乳动物雷帕霉素靶蛋白通路过度激活、高胰岛素血症、自噬-溶酶体蛋白水解功能减弱、自噬体膜及溶酶体膜脂质构成改变、肝细胞内钙离子水平增加引起自噬减弱,加重了NAFLD。
Abstract:
Autophagy is a pathway of degradation dependent on lysosome. A number of studies reported autophagy was involved in the occurrence and development of nonalcoholic fatty liver disease(NAFLD). Autophagy is enhanced in the early stage of NAFLD, and can delay the progress of NAFLD by inhibiting the "secondary stroke" which can induce NAFLD. In the late stage of NAFLD, degradation of autophagy related gene(Atg)7, activation of excessive mammalian rapamycin target protein pathway, hyperinsulinemia, dysfunction of autophagy-lysosome membrane protein hydrolysis, change of lipid composition in autophagosome and lysosome membrane, increase of calcium in the hepatocyte can inhibit autophagy, thus aggravate NAFLD.

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备注/Memo

备注/Memo:
基金项目:山西省归国留学基金资助项目(2011-108); 山西省自然科学基金资助项目(2013011048-3); 山西省卫计委科技攻关计划项目(2014002) 通信作者:郗光霞,Email: bettyxgx2006@hotmail.com
更新日期/Last Update: 2017-01-20