参考文献/References:
[1] Di Sarra D,Tosi F,Bonin C,et al.Metabolic inflexibility is a feature of women with polycystic ovary syndrome and is associated with both insulin resistance and hyperandrogenism[J].J Clin Endocrinol Metab,2013,98（6）：2581-2588.
[2] Qin JZ,Pang LH,Li MJ,et al.Obstetric complications in women with polycystic ovary syndrome：a systematic review and meta-analysis[J].Reprod Biol Endocrinol,2013,11：56.
[3] Ghazeeri GS,Nassar AH,Younes Z,et al.Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome：an overview[J].Acta Obstet Gynecol Scand,2012,91（6）：658-678.
[4] Kamalanathan S,Sahoo JP,Sathyapalan T.Pregnancy in polycystic ovary syndrome[J].Indian J Endocrinol Metab,2013,17（1）：37-43.
[5] Banerjee P,Bhonde RR,Pal R.Diverse roles of metformin during peri-implantation development：revisiting novel molecular mech-anisms underlying clinical implications[J].Stem Cells Dev,2013,22（22）：2927-2934.
[6] Zhang T,He J,Xu C,et al.Mechanisms of metformin inhibiting lipolytic response to isoproterenol in primary rat adipocytes[J].J Mol Endocrinol,2009,42（1）：57-66.
[7] Fux Otta C,Wior M,Iraci GS,et al.Clinical,metabolic,and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome：a ran-domized,double-blind,and placebo control trial[J].Gynecol Endocrinol,2010,26（3）：173-178.
[8] Ghazeeri GS,Nassar AH,Younes Z,et al.Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome：an overview[J].Acta Obstet Gynecol Scand,2012,91（6）：658-678.
[9] Hong Y,Xie QX,Chen CY,et al.Insulin resistance in first-trimester pregnant women with pre-pregnant glucose tolerance and history of recurrent spontaneous abortion[J].J Biol Regul Homeost Agents, 2013,27（1）：225-231.
[10] Chakraborty P,Goswami SK,Rajani S,et al.Recurrent pregnancy loss in polycystic ovary syndrome：role of hyperhomocysteinemia and insulin resistance[J].PLoS One,2013,8（5）：e64446.
[11] Rittenberg V,Seshadri S,Sunkara SK,et al.Effect of body mass index on IVF treatment outcome：an updated systematic review and meta-analysis[J].Reprod Biomed Online,2011,23（4）：421-439.
[12] Sohrabvand F,Shariat M,Haghollahi F,et al.Effect of metformin on miscarriage in pregnant patients with polycystic ovary syn-drome[J]. West Indian Med J,2009,58（5）：433-436.
[13] Nawaz FH,Rizvi J.Continuation of metformin reduces early pregnancy loss in obese Pakistani women with polycystic ovarian syndrome[J].Gynecol Obstet Invest,2010,69（3）：184-189.
[14] Morin-Papunen L,Rantala AS,Unkila-Kallio L,et al.Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome（PCOS）：a multicenter,double-blind,placebo-controlled randomized trial[J].J Clin Endocrinol Metab, 2012,
97（5）：1492-1500.
[15] Veltman-Verhulst SM,van Haeften TW,Eijkemans MJ,et al.Sex hormone-binding globulin concentrations before conception as a predictor for gestational diabetes in women with polycystic ovary syndrome[J]. Hum Reprod,2010,25（12）：3123-3128.
[16] Forsum E,Brants?覸ter AL,Olafsdottir AS,et al.Weight loss before conception：A systematic literature review[J].Food Nutr Res,2013：57.
[17] De Leo V,Musacchio MC,Piomboni P,et al.The administration of metformin during pregnancy reduces polycystic ovary syn-drome related gestational complications[J].Eur J Obstet Gynecol Reprod Biol, 2011,157（1）：63-66.
[18] Zheng J,Shan PF,Gu W.The efficacy of metformin in pregnant women with polycystic ovary syndrome：A meta-analysis of clinical trials[J]. J Endocrinol Invest,2013,36（10）：797-802.
[19] Romualdi D,De Cicco S,Gagliano D,et al.How metformin acts in PCOS pregnant women：insights into insulin secretion and peripheral action at each trimester of gestation[J].Diabetes Care,2013,36（6）：1477-1482.
[20] Fauser BC,Tarlatzis BC,Rebar RW,et al.Consensus on women's health aspects of polycystic ovary syndrome （PCOS）：the Ams-terdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group[J]. Fertil Steril,2012,97（1）：28-38.e25.
[21] Mladenova M,Dimitrakova E,Amaliev G,et al.Insulin resistance in preeclampsia[J].Akush Ginekol （Sofiia）,2011,50（7）：31-33.
[22] Valdés E,Sepúlveda-Martínez A,Manukián B,et al.Assessment of pregestational insulin resistance as a risk factor of preeclampsia[J].Gynecol Obstet Invest,2014,77（2）：111-116.
[23] Mladenova M,Dimitrakova E,Pehlivanov B,et al.The role of insulin resistace in preeclampsia[J].Akush Ginekol （Sofiia）,2013,52（4）：5-9.
[24] Lilja AE,Mathiesen ER.Polycystic ovary syndrome and met-formin in pregnancy[J].Acta Obstet Gynecol Scand,2006,85（7）：861-868.
[25] R?覬 TB,Ludvigsen HV,Carlsen SM,et al.Growth,body composi-tion and metabolic profile of 8-year-old children exposed to metformin in utero[J].Scand J Clin Lab Invest,2012,72（7）：570-575.
[26] Niromanesh S,Alavi A,Sharbaf FR,et al.Metformin compared with insulin in the management of gestational diabetes mellitus：a randomized clinical trial[J].Diabetes Res Clin Pract,2012,98（3）：422-429.
[27] 王蕴慧,张留苗,谭剑平,等.早孕期服用二甲双胍对合并多囊卵巢综合征孕妇妊娠结局的影响[J].中华围产医学杂志,2011,
14（10）：592-597.
[28] Vanky E,Stridsklev S,Heimstad R,et al.Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome：a randomized,controlled multicenter study[J].J Clin Endocrinol Metab, 2010,95（12）：E448-E455.
[29] Nawaz FH,Khalid R,Naru T,et al.Does continuous use of metformin throughout pregnancy improve pregnancy outcomes in women with polycystic ovarian syndrome?[J].J Obstet Gynaecol Res,2008,34（5）：832-837.
[30] de Jager J,Kooy A,Lehert P,et al.Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency：randomised placebo controlled trial[J].BMJ,2010,340：c2181.
[31] de Groot-Kamphuis DM,van Dijk PR,Groenier KH,et al.Vitamin B12 deficiency and the lack of its consequences in type 2 dia-betes patients using metformin[J].Neth J Med,2013,71（7）：386-390.
[32] Xu L,Huang Z,He X,et al.Adverse effect of metformin therapy on serum vitamin B12 and folate：short-term treatment causes disadvantages?[J].Med Hypotheses,2013,81（2）：149-151.
[33] Saadi T,Waterman M,Yassin H,et al.Metformin-induced mixed hepatocellular and cholestatic hepatic injury：case report and literature review[J]. Int J Gen Med, 2013,6：703-706.
[34] Cone CJ,Bachyrycz AM,Murata GH.Hepatotoxicity associated with metformin therapy in treatment of type 2 diabetes mellitus with nonalcoholic fatty liver disease[J].Ann Pharmacother,2010,
44（10）：1655-1659.
[35] Legro RS,Arslanian SA,Ehrmann DA,et al.Diagnosis and treatment of polycystic ovary syndrome：an endocrine society clinical practice guideline[J].J Clin Endocrinol Metab,2013,98（12）：4565-4592.
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