[1]张若男,何军华.MicroRNA介导的胰岛β细胞去分化研究进展[J].国际内分泌代谢杂志,2024,44(01):31-34.[doi:10.3760/cma.j.cn121383-20230404-04004]
 Zhang Ruonan,He Junhua.Research progress on dedifferentiation of pancreatic β cells mediated by microRNA[J].International Journal of Endocrinology and Metabolism,2024,44(01):31-34.[doi:10.3760/cma.j.cn121383-20230404-04004]
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MicroRNA介导的胰岛β细胞去分化研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
44
期数:
2024年01期
页码:
31-34
栏目:
综述
出版日期:
2024-01-20

文章信息/Info

Title:
Research progress on dedifferentiation of pancreatic β cells mediated by microRNA
作者:
张若男何军华
山西医科大学第二医院内分泌科,太原 030001
Author(s):
Zhang Ruonan He Junhua
Department of Endocrinology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China
关键词:
微RNA 胰岛β细胞 去分化
Keywords:
microRNA Islet β cells Dedifferentiation
DOI:
10.3760/cma.j.cn121383-20230404-04004
摘要:
微RNA(microRNA,miRNA)是一类基因表达的负性调控因子,已经成为重要的非编码RNA,调节细胞生理及病理状况下的反应。越来越多的文献强调miRNA在胰岛β细胞遗传、发育、代谢和炎症应激中的重要作用。β细胞是胰岛中的一种内分泌细胞,其主要功能是合成和分泌胰岛素,维持血糖水平的稳定。目前β细胞去分化被认为是糖尿病发病的另外一种机制,β细胞的功能衰竭与β细胞去分化密切相关。在这篇综述中,我们旨在总结调控β细胞去分化的几种重要的miRNA以及最新研究成果。
Abstract:
MicroRNA(miRNA), a class of negative regulators of gene expression, have become important non-coding RNA that regulate the response of cells under physiological and pathological conditions. More and more literature emphasizes the important role of miRNA in the inheritance, development, metabolism and inflammatory stress of pancreatic islet β cell. β cell is a kind of endocrine cell in the islet, its main function is to synthesize and secrete insulin and maintain the stability of blood sugar level. At present, β cell dedifferentiation is considered to be another mechanism of diabetes, and β cell failure is closely related to β cell dedifferentiation. In this review, we aim to summarize several important miRNAs that regulate β cell dedifferentiation and the latest research results.

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备注/Memo

备注/Memo:
基金项目:山西省科技合作交流专项项目(202204041101024); 山西省回国留学人员科研资助项目(2021-169); 山西省卫生健康委科研课题(2019041)
通信作者:何军华,Email:13007000339@163.com
更新日期/Last Update: 2024-03-20