[1]胡剑,肖卓妮,徐望明.脂肪细胞外泌体在2型糖尿病及糖尿病心血管并发症中作用的研究进展[J].国际内分泌代谢杂志,2021,41(03):233-236.[doi:10.3760/cma.j.cn121383-20200513-05028]
 Hu Jian,Xiao Zhuoni,Xu Wangming..Research progress of the effects of adipocyte-derived exosomes on type 2 diabetes and diabetic cardiovascular complications[J].International Journal of Endocrinology and Metabolism,2021,41(03):233-236.[doi:10.3760/cma.j.cn121383-20200513-05028]
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脂肪细胞外泌体在2型糖尿病及糖尿病心血管并发症中作用的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年03期
页码:
233-236
栏目:
综述
出版日期:
2021-05-20

文章信息/Info

Title:
Research progress of the effects of adipocyte-derived exosomes on type 2 diabetes and diabetic cardiovascular complications
作者:
胡剑肖卓妮徐望明
武汉大学人民医院生殖医学中心 430060
Author(s):
Hu Jian Xiao Zhuoni Xu Wangming.
Department of Reproductive Medical Centre, Renmin Hospital of Wuhan University, Wuhan 430060, China
关键词:
肥胖 外泌体 糖尿病 心血管疾病 脂肪细胞
Keywords:
Obesity Exosomes Diabetes mellitus Cardiovascular diseases Adipocyte
DOI:
10.3760/cma.j.cn121383-20200513-05028
摘要:
外泌体是细胞分泌的直径在30~100 nm的囊泡,作为载体传递其内容物至靶细胞发挥生物学效应。近年来许多研究表明,脂肪组织来源的外泌体是循环内外泌体的重要来源,脂肪细胞通过外泌体内容物与巨噬细胞、血管内皮细胞、肝脏、骨骼肌等细胞或器官进行对话,参与肥胖相关疾病如2型糖尿病、心血管疾病的病理生理过程。对脂肪细胞外泌体进行深入研究,将为肥胖相关疾病的发生机制提供新的解释,并为疾病的诊断及治疗提供新的思路。
Abstract:
Exosomes are vesicles with a diameter of 30-100 nm, which deliver their contents to target cells to execute biological effects as a van.In recent years, many researches indicate that adipose-derived exosomes are important sources of exosomes in circulation. Adipocytes conduct dialogues with macrophages,vascular endothelial cells, liver, skeletal muscle and other cells or organs by delivering contents of exosomes, which involves in the physiological and pathological process of obesity-related diseases such as type 2 diabetes and cardiovascular diseases. Further study of adipocyte-derived exosomes will provide a new explanation for the pathogenesis of obesity-related diseases, and a new thinking for diagnosis and treatment of diseases.

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备注/Memo

备注/Memo:
通信作者:徐望明,Email:wmxu609@msn.com 基金项目:国家自然科学基金(81471455; 81100418)
更新日期/Last Update: 2021-05-20