参考文献/References:
[1] Zheng Y,Ley SH,Hu FB.Global aetiology and epidemiology of type 2 diabetes mellitus and its complications[J].Nat Rev Endocrinol,2018,14(2):88-98.DOI:10.1038/nrendo.2017.151.
[2] Prasad M,Chen EW,Toh SA,et al.Autoimmune responses and inflammation in type 2 diabetes[J].J Leukoc Biol,2020,107(5):739-748.DOI:10.1002/JLB.3MR0220-243R.
[3] Zatterale F,Longo M,Naderi J,et al.Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes[J].Front Physiol,2020,10:1607.DOI:10.3389/fphys.2019.01607.
[4] Simanshu DK,Nissley DV,McCormick F.RAS proteins and their regulators in human disease[J].Cell,2017,170(1):17-33.DOI:10.1016/j.cell.2017.06.009.
[5] Yang Y,Li L,Wong GW,et al.RasGRP4,a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs.Identification of defective variants of this signaling protein in asthma,mastocytosis,and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function[J].J Biol Chem,2002,277(28):25756-25774.DOI:10.1074/jbc.M202575200.
[6] Hashimoto T,Yasuda S,Koide H,et al.Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis[J].Arthritis Res Ther,2011,13(5):R154.DOI:10.1186/ar3470.
[7] Zhu L,Xia C,Wu L,et al.The critical role of RasGRP4 in the growth of diffuse large B cell lymphoma[J].Cell Commun Signal,2019,17(1):92.DOI:10.1186/s12964-019-0415-6.
[8] Kono M,Yasuda S,Stevens RL,et al.Ras guanine nucleotide-releasing protein 4 is aberrantly expressed in the fibroblast-like synoviocytes of patients with rheumatoid arthritis and controls their proliferation[J].Arthritis Rheumatol,2015,67(2):396-407.DOI:10.1002/art.38924.
[9] Adachi R,Krilis SA,Nigrovic PA,et al.Ras guanine nucleotide-releasing protein-4(RasGRP4)involvement in experimental arthritis and colitis[J].J Biol Chem,2012,287(24):20047-20055.DOI:10.1074/jbc.M112.360388.
[10] Higa M,Shimabukuro M,Shimajiri Y,et al.Protein kinase B/Akt signalling is required for palmitate-induced beta-cell lipotoxicity[J].Diabetes,Obes Metab,2006,8(2):228-233.DOI:10.1111/j.1463-1326.2005.00488.x.
[11] Chen X,Xu S,Wei S,et al.Comparative proteomic study of fatty acid-treated myoblasts reveals role of Cox-2 in palmitate-induced insulin resistance[J].Sci Rep,2016,6(1):21454.DOI:10.1038/srep21454.
[12] 梁书卉,王阳,孙续图,等.空腹血糖受损人群炎症标志物与胰岛素抵抗、胰岛β细胞功能受损的相关性分析[J].天津医科大学学报,2020,26(3):266-270.
[13] Tang SCW,Yiu WH.Innate immunity in diabetic kidney disease[J].Nat Rev Nephrol,2020,16(4):206-222.DOI:10.1038/s41581-019-0234-4.
[14] 张路,姚平.炎症因子及氧化应激在糖尿病肾病中的作用[J].临床内科杂志,2018,35(2):141-142.DOI:10.3969/j.issn.1001-9057.2018.02.026.
[15] Xie K,Xu B,Zhang Y,et al.A multi-method evaluation of the effects of inflammatory cytokines(IL-1β,IFN-γ,TNF-α)on pancreatic β-cells[J].J Cell Physiol,2018,233(12):9375-9382.DOI:10.1002/jcp.26518.
[16] Neelofar K,Arif Z,Arafat MY,et al.A study on correlation between oxidative stress parameters and inflammatory markers in type 2 diabetic patients with kidney dysfunction in north Indian population[J].J Cell Biochem,2019,120(4):4892-4902.DOI:10.1002/jcb.27763.
[17] Fernández-Juárez G,Villacorta Perez J,Luño Fernández JL,et al.High levels of circulating TNFR1 increase the risk of all-cause mortality and progression of renal disease in type 2 diabetic nephropathy[J].Nephrology(Carlton),2017,22(5):354-360.DOI:10.1111/nep.12781.
[18] Das AK,Kalra S,Tiwaskar M,et al.Expert Group Consensus Opinion:role of anti-inflammatory agents in the management of type-2 diabetes(T2D)[J].J Assoc Physicians India,2019,67(12):65-74.
[19] Ruscitti P,Masedu F,Alvaro S,et al.Anti-interleukin-1 treatment in patients with rheumatoid arthritis and type 2 diabetes(TRACK):a multicentre,open-label,randomised controlled trial[J].PLoS Med,2019,16(9):e1002901.DOI:10.1371/journal.pmed.1002901.
[20] Agrawal S,Maity S,AIRaawi Z,et al.Targeting drugs against fibroblast growth factor(s)-induced cell signaling[J].Curr Drug Targets,2021,22(2):214-240.DOI:10.2174/1389450121999201012201926.
[21] Akan DT,Howes JE,Sai J,et al.Small molecule SOS1 agonists modulate MAPK and PI3K signaling via independent cellular responses[J].ACS Chem Biol,2019,14(3):325-331.DOI:10.1021/acschembio.8b00869.
[22] 李昕,于珮,于德民,等.信号蛋白RasGRP4对自然杀伤细胞干扰素-γ分泌的调控作用[J].国际内分泌与代谢杂志,2018,38(6):374-380.DOI:10.3760/cma.j.issn.1673-4157.2018.06.004.
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