[1]王瑜 崔景秋.肠道菌群与白色脂肪棕色化及棕色脂肪活化的关系[J].国际内分泌代谢杂志,2020,40(03):188-192.[doi:10.3760/cma.j.issn.1673-4157.2020.03.010]
　Wang Yu,Cui Jingqiu.Relationship between gut microbiota and browning of white adipose tissue, activation of brown adipose tissue[J].International Journal of Endocrinology and Metabolism,2020,40(03):188-192.[doi:10.3760/cma.j.issn.1673-4157.2020.03.010]
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肠道菌群与白色脂肪棕色化及棕色脂肪活化的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
40
期数:
2020年03期
页码:
188-192
栏目:
综述
出版日期:
2020-05-20

文章信息/Info

Title:
Relationship between gut microbiota and browning of white adipose tissue, activation of brown adipose tissue
作者:
王瑜 崔景秋
天津医科大学总医院内分泌代谢科 300052
Author(s):
Wang Yu;  Cui Jingqiu
Department of Endocrinology and Metabolism, The General Hospital, Tianjin Medical University, Tianjin 300052, China
关键词:
肠道菌群;  白色脂肪组织;  棕色脂肪组织;  肥胖
Keywords:
Gut microbiota;  White adipose tissue;  Brown adipose tissue;  Obesity
DOI:
10.3760/cma.j.issn.1673-4157.2020.03.010
摘要:
肥胖及相关代谢异常的发病率逐年增加,寻找新的治疗策略成为迫切需要。白色脂肪组织(WAT)与棕色脂肪组织(BAT)产热增加,会增加能量消耗。近来研究发现,肠道菌群可以促进BAT活化及WAT棕色化,生理性应激反应如间歇性空腹、寒冷暴露、内源性大麻素系统,可影响肠道菌群对脂肪组织的作用。其机制涉及肠道菌群的代谢产物如胆汁酸、短链脂肪酸及其结构组分如脂多糖。对肠道菌群在WAT棕色化及BAT活化中作用的研究,有助于探讨肥胖的发生机制,并有助于寻找新的靶点。
Abstract:
Given the increasing prevalence of obesity and associated metabolic disturbances, novel therapeutic strategies are imperatively required. Studies have showed that the enhancement of thermogenesis in white adipose tissue(WAT)and brown adipose tissue(BAT)can increase energy expenditure. Recent studies have also showed that gut microbiota could promote the browning of WAT and BAT activation. Both physiological stress conditions such as intermittent fasting, cold exposure and endocannabinoid system can influence the effects of gut microbiota on adipose tissue. The mechanism may be related to the metabolites of gut microbiota including bile acid, short-chain fatty acids and its structural components such as lipopolysaccharides. The research of the effects of gut microbiota on the browning of WAT and BAT activation will contribute to investigate the pathogenesis of obesity, and to find a novel target.

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备注/Memo

备注/Memo:
通信作者:崔景秋,Email:cuijingqiu@sina.com
Corresponding author: Cui Jingqiu, Email:cuijingqiu@sina.com
更新日期/Last Update: 2020-05-20