参考文献/References:
[1] van der Klaauw AA, Farooqi IS. The hunger genes: pathways to obesity[J].Cell,2015,161(1):119-132.DOI:10.1016/j.cell.2015.03.008.
[2] Pigeyre M, Yazdi FT, Kaur Y, et al. Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity[J].Clin Sci(Lond),2016,130(12):943-986.DOI:10.1042/CS20160136.
[3] Apalasamy YD,Mohamed Z.Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity[J].Hum Genet,2015,134(4):361-374.DOI:10.1007/s00439-015-1533-x.
[4] Wannaiampikul S, Phonrat B, Tungtrongchitr A,et al. Genetic variant screening of MC3R and MC4R genes in early-onset obese children and their relatives among a Thai population: family-based study[J].Genet Mol Res,2015,14(4):18090-18102. DOI:10.4238/2015.December.22.35.
[5] Srivastava A,Mittal B,Prakash J,et al. Analysis of MC4R rs17782313, POMC rs1042571, APOE-Hha1 and AGRP rs3412352 genetic variants with susceptibility to obesity risk in North Indians[J].Ann Hum Biol,2016,43(3):285-288.DOI:10.3109/03014460.2015.1061597.
[6] Kühnen P,Handke D,Waterland RA,et al. Interindividual variation in DNA methylation at a putative POMC metastable epiallele is associated with obesity[J].Cell Metab,2016,24(3):502-509.DOI:10.1016/j.cmet.2016.08.001.
[7] Neocleous V, Shammas C, Phelan MM, et al. A novel MC4R deletion coexisting with FTO and MC1R gene variants, causes severe early onset obesity[J].Hormones(Athens),2016,15(3):445-452.DOI:10.14310/horm.2002.1686.
[8] Lazopoulou N,Gkioka E,Ntalla I,et al. The combined effect of MC4R and FTO risk alleles on childhood obesity in Greece[J].Hormones(Athens),2015,14(1):126-133.DOI:10.14310/horm.2002.1524.
[9] Fernandes AE,de Melo ME,Fujiwara CT,et al. Associations between a common variant near the MC4R gene and serum triglyceride levels in an obese pediatric cohort[J].Endocrine,2015,49(3):653-658.DOI:10.1007/s12020-015-0616-8.
[10] Lee IT,Wang JS,Fu CP,et al. Relationship between body weight and the increment in serum brain-derived neurotrophic factor after oral glucose challenge in men with obesity and metabolic syndrome: a prospective study[J].Medicine(Baltimore),2016,95(43):e5260. DOI:10.1097/MD.0000000000005260.
[11] Mou Z,Hyde TM,Lipska BK,et al. Human obesity associated with an intronic SNP in the brain-derived neurotrophic factor locus[J].Cell Rep,2015,13(6):1073-1080.DOI:10.1016/j.celrep.2015.09.065.
[12] Gardner KR, Sapienza C,Fisher JO. Genetic and epigenetic associations to obesity-related appetite phenotypes among African-American children[J].Pediatr Obes,2015,10(6):476-482.DOI:10.1111/ijpo.12010.
[13] Aerts E,Beckers S,Zegers D,et al. Genetic and structural variation in the SH2B1 gene in the Belgian population[J].Mol Genet Metab,2015,115(4):193-198.DOI:10.1016/j.ymgme.2015.05.010.
[14] Mansego ML,Milagro FI,Zulet MA,et al. SH2B1 CpG-SNP is associated with body weight reduction in obese subjects following a dietary restriction program[J].Ann Nutr Metab,2015,66(1):1-9.DOI:10.1159/000368425.
[15] Gutierrez-Aguilar R,Thompson A, Marchand N,et al. The obesity-associated transcription factor ETV5 modulates circulating glucocorticoids[J].Physiol Behav,2015,150:38-42.DOI:10.1016/j.physbeh.2015.03.027.
[16] Mechaly AS,Richardson E,Rinkwitz S. Activity of etv5a and etv5b genes in the hypothalamus of fasted zebrafish is influenced by serotonin[J].Gen Comp Endocrinol,2017,246:233-240.DOI:10.1016/j.ygcen.2016.12.013.
[17] Koh B,Hufford MM,Pham D,et al. The ETS family transcription factors Etv5 and PU.1 function in parallel to promote Th9 cell development[J].J Immunol,2016,197(6):2465-2472.DOI:10.4049/jimmunol.1502383.
[18] Koh B,Hufford MM,Sun X,et al. Etv5 regulates IL-10 production in Th cells[J].J Immunol,2017,198(5):2165-2171.DOI:10.4049/jimmunol.1600801.
[19] 张美仙,赵小元,席波,等.基因多态性对儿童肥胖和代谢异常的影响[J].中华预防医学杂志,2014,48(9):776-783.DOI:10.376/cma.j.issn.0253-9624.2014.09.007.
[20] Wu L,Zhao X,Shen Y,et al. Promoter methylation of fas apoptotic inhibitory molecule 2 gene is associated with obesity and dyslipidaemia in Chinese children[J].Diab Vasc Dis Res,2015,12(3):217-220.DOI:10.1177/1479164114565630.
[21] Wu L,Zhao X,Shen Y,et al. Influence of lifestyle on the FAIM2 promoter methylation between obese and lean children: a cohort study[J].BMJ Open,2015,5(4):e007670.DOI:10.1136/bmjopen-2015-007670.
[22] Buzaglo-Azriel L,Kuperman Y,Tsoory M,et al. Loss of muscle MTCH2 increases whole-body energy utilization and protects from diet-induced obesity[J].Cell Rep,2016,14(7):1602-1610.DOI:10.1016/j.celrep.2016.01.046.
[23] Weiss TS,Lupke M,Ibrahim S,et al. Attenuated lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liverregeneration by different pathways[J].PLoS One,2017,12(9):e0184282.DOI:10.1371/journal.pone.0184282.
[24] Bar-Lev Y,Moshitch-Moshkovitz S, Tsarfaty G,et al. Mimp/Mtch2, an obesity susceptibility gene, induces alteration of fatty acid metabolism in transgenic mice[J].PLoS One,2016,11(6):e0157850.DOI:10.1371/journal.pone.0157850.
[25] Decara J,Rivera P,Arrabal S,et al. Cooperative role of the glucagon-like peptide-1 receptor and β3-adrenergic-mediated signalling on fat mass reduction through the downregulation of PKA/AKT/AMPK signalling in the adipose tissue and muscle of rats[J].Acta Physiol(Oxf),2018,222(4):e13008.DOI:10.1111/apha.13008.
[26] Claussnitzer M,Dankel SN,Kim KH,et al. FTO obesity variant circuitry and adipocyte browning in humans[J].N Engl J Med,2015,373(10):895-907.DOI:10.1056/NEJMoa1502214.
[27] Jiao Y,Zhang J,Lu L,et al. The Fto gene regulates the proliferation and differentiation of pre-adipocytes in vitro[J].Nutrients,2016,8(2):102.DOI:10.3390/nu8020102.
[28] Ronkainen J,Mondini E,Cinti F,et al. Fto-deficiency affects the gene and microRNA expression involved in brown adipogenesis and browning of white adipose tissue in mice[J].Int J Mol Sci,2016,17(11). pii: E1851.DOI:10.3390/ijms17111851.
[29] Kühn AB,Feis DL,Schilbach L,et al. FTO gene variant modulates the neural correlates of visual food perception[J].Neuroimage,2016,128:21-31.DOI:10.1016/j.neuroimage.2015.12.049.
[30] Liu S,Wilson JG,Jiang F,et al. Multi-variant study of obesity risk genes in African Americans: the Jackson heart study[J].Gene,2016,593(2):315-321.DOI:10.1016/j.gene.2016.08.041.
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